A5013882378- Cardiac electrophysiology and arrhythmias
- Chemotherapy-induced cardiotoxicity and mitigation
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Cardiac Fibrosis and Remodeling
- Tracheal and airway disorders
- Cardiac Imaging and Diagnostics
- Nerve injury and regeneration
- Transplantation: Methods and Outcomes
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Synthesis of Tetrazole Derivatives
- Chronic Myeloid Leukemia Treatments
- HER2/EGFR in Cancer Research
- Advanced MRI Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
The Ohio State University Wexner Medical Center
2020-2024
The Ohio State University
2022-2024
Lung Institute
2022-2024
Columbus State Community College
2022-2023
Twitter (United States)
2022
National Institute of Mental Health
2016
National Institutes of Health
2016
Synthesis and regulation of catecholamine neurotransmitters in the central nervous system are implicated pathogenesis a number neuropsychiatric disorders. To identify factors that regulate presynaptic synthesis catecholamines, we tested hypothesis rate-limiting enzyme biosynthetic pathway, tyrosine hydroxylase (TH), is locally synthesized axons nerve terminals noradrenergic neurons. isolate pure axonal mRNA protein, rat superior cervical ganglion sympathetic neurons were cultured...
IntroductionAs lung transplant candidates are older with increased comorbidities, we sought to examine the prevalence and outcomes of recipients after prior cardiac surgery.MethodsLung transplants were identified from United Network for Organ Sharing/Organ Procurement Transplantation Database. Patients stratified based on surgery (No Surgery [NS], Prior coronary artery bypass grafting [CABG], Valve [Valve]). Unadjusted comparisons performed amongst all groups, propensity matching was...
Background: The cardiac dyad is composed of the transverse-tubules, junctional sarcoplasmic reticulum (jSR), and its associated calcium (Ca 2+ ) release units, which are integral for excitation-contraction (E-C). Proper E-C coupling requires Ca influx via L-type channels (LTCC) triggers from adjacent ryanodine receptor 2 (RyR2) receptors located in jSR. Loss βII-spectrin scaffolding protein alters RyR2 localization; however, contribution to organization remains unclear. Hypothesis: We...
Background: Dysregulation of cardiac cytoskeletal proteins such as βII-spectrin has been recognized to promote accelerated heart failure (HF) and arrhythmias in human mouse models. However, the mechanism by which dysregulation underlies HF is poorly understood. Hypothesis: We hypothesized that cardiomyocyte loss leads recruitment inflammatory macrophages augment remodeling promoting arrhythmogenesis increased susceptibility HF. Methods: Cardiomyocyte-specific knockout (βII-cKO) control mice...
Background: The cardiac dyad and associated calcium (Ca 2+ ) release units (CRUs) are integral for excitation-contraction (E-C) coupling. is a multicomponent complex composed of the transverse-tubules, junctional sarcoplasmic reticulum (jSR), CRU-associated proteins. Proper E-C coupling requires Ca influx via long-lasting-L-type channels (Cav1.2), which triggers from adjacent ryanodine receptor 2 (RyR2) located in jSR. βII-spectrin loss alters RyR2 localization, but its contribution to...