A5033524138- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Multiple and Secondary Primary Cancers
- Cancer Genomics and Diagnostics
- Metabolism, Diabetes, and Cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Nutrition and Health in Aging
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Metabolism and Genetic Disorders
- Multiple Myeloma Research and Treatments
- 3D Printing in Biomedical Research
- Synthesis and bioactivity of alkaloids
- Cancer Treatment and Pharmacology
- Cardiovascular Health and Risk Factors
- Cancer, Hypoxia, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Acute Myeloid Leukemia Research
- BRCA gene mutations in cancer
- Brain Metastases and Treatment
- Histone Deacetylase Inhibitors Research
University of North Carolina at Chapel Hill
2019-2024
UCLA Health
2024
Stanford University
2023-2024
University of California, Los Angeles
2023-2024
UNC Lineberger Comprehensive Cancer Center
2021-2024
University of California System
2024
Stanford Medicine
2024
Public Health Department
2022
Center for Food Safety and Applied Nutrition
2013-2020
United States Food and Drug Administration
2014-2019
Synthesis and regulation of catecholamine neurotransmitters in the central nervous system are implicated pathogenesis a number neuropsychiatric disorders. To identify factors that regulate presynaptic synthesis catecholamines, we tested hypothesis rate-limiting enzyme biosynthetic pathway, tyrosine hydroxylase (TH), is locally synthesized axons nerve terminals noradrenergic neurons. isolate pure axonal mRNA protein, rat superior cervical ganglion sympathetic neurons were cultured...
Abstract Background To describe reasons for deviations from planned chemotherapy treatments in women with nonmetastatic breast cancer that contribute to less-than-planned receipt of chemotherapy. Methods Electronic medical records patients receiving were reviewed adverse events and treatment modifications. Log-binomial regression models used estimate relative risks (RRs) 95% CIs examine associations between modifications, patient characteristics, modalities. Results Delays initiation (7%)...
Abstract Background Nasopharyngeal carcinoma (NPC) mortality varies based on multiple risk factors. While NPC is higher in Asia, little known about Asian subgroups the United States (US). Methods Using 2005–2020 National Vital Statistics System, we examined by age, race (non‐Hispanic black, Hispanic white (HW), non‐Hispanic (NHW), Chinese, Filipino, Indian, Japanese, Korean, Vietnamese), sex, and nativity (Untied or foreign‐born). Results Upon disaggregation, Chinese (1.96 [CI: 1.78–2.16]),...
Genomic tests, such as the Oncotype Dx 21-gene and Prosigna risk of recurrence (ROR-P) assay, are commonly used for breast cancer prognostication. Emerging data suggest variability between assays, but this has not been compared in diverse populations.
Abstract Background The plasma cell disorders (PCDs), multiple myeloma (MM), and light-chain amyloidosis (AL) are disproportionately diseases of older adults, whose care may be complicated by frailty associated with advancing age. We sought to evaluate the prevalence functional deficits symptoms in a cohort persons PCDs associations demographic, disease-related, functional, psychosocial measures quality life (QoL). Patients Methods Adults were recruited into an observational registry...
Phenethylamines are ingredients in many dietary supplements aimed at supporting weight loss or maintaining heightened energy levels for productive workouts. This class of compounds affects the central nervous and cardiac systems, but there is evidence that 2-phenethylamine itself its derivatives can accumulate kidneys induce nephrotoxicity. As such, we investigated possible nephrotoxic effects two naturally occurring compounds: N, N-dimethyl-β-phenethylamine, alone combination, because they...
A recent surge in the use of dietary supplements, including herbal remedies, necessitates investigations into their safety profiles. "Dream herb," Calea zacatechichi, has long been used traditional folk medicine for a variety purposes and is currently being marketed US medicinal purposes, diabetes treatment. Despite inherent vulnerability renal system to xenobiotic toxicity, there lack studies on nephrotoxic potential this herb. Additionally, high frequency diabetes-associated kidney disease...
Diglycolic acid (DGA) is present in trace amounts our food supply and classified as an indirect additive linked with the primary GRAS carboxymethyl cellulose (CMC). Carboxymethyl starches are used a filler/binder excipient dietary supplement tablets thickening ingredient many other processed foods. We sought to utilize human proximal tubule HK-2 cell line vitro cellular model system evaluate its acute nephrotoxicity of DGA. found that DGA was indeed toxic cells all assays study, including...
Background: Of the 1.8 million global incident lung cancer cases estimated in 2012, approximately 60% occurred less developed regions. Prior studies suggest sex differences risk and a potential role for reproductive hormonal factors among women. However, majority of these were conducted No prior study has assessed relationships Nepali Methods: Using data from hospital-based case-control B. P. Koirala Memorial Cancer Hospital (Nepal, 2009-2012), between examined women aged 23-85 years. Lung...
Adhatoda zeylanica is a dietary supplement ingredient present in several types of supplements, including weight loss, respiratory relief, and immune regulating products. Due to its reported wide range uses folk medicine, it was hypothesized that may have the potential target multiple organs lead toxicity features. As preliminary evaluation safety this herbal ingredient, an investigation into effects on kidney sought. An vitro study nephrotoxicity using HK-2 human proximal tubule cell line...
Abstract Introduction Financial toxicity (FT) is a growing concern among cancer survivors that adversely affects the quality of life and survival. Individuals diagnosed with aggressive cancers are often at greater risk experiencing FT. The objectives this study were to estimate FT prostate (PCa) after 10−15 years diagnosis, assess relationship between PCa aggressiveness diagnosis FT, examine whether current treatment status mediates Methods patients enrolled in North Carolina‐Louisiana...
Introduction: Chordoma is a rare primary malignant tumor and remnant of the primitive notochord. Another neoplasm, chondrosarcoma, thought to arise from cartilaginous cells, fibroblasts, or mesenchymal cells. chondrosarcoma each account for <1% all intracranial tumors. Despite indolent growth patterns low metastatic risk, both chordomas chondrosarcomas are locally aggressive destructive with high rates recurrence. To date, there no reports racial ethnic disparities in surgical outcomes...
INTRODUCTION: Evolving brain metastases treatment standards has led to shifting intracranial recurrence patterns, especially with respect pachymeningeal and leptomeningeal disease (PMD/LMD). As an emerging technique, it remains unclear if the depth of magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) is associated frequency iatrogenic PMD/LMD. METHODS: A single-institute retrospective analysis patients who underwent LITT surgery between 2014 2022 was conducted...