A5086040234- HIV Research and Treatment
- Mosquito-borne diseases and control
- Synthetic Organic Chemistry Methods
- Microbial Natural Products and Biosynthesis
- Studies on Chitinases and Chitosanases
- HIV/AIDS drug development and treatment
- Asymmetric Synthesis and Catalysis
- Signaling Pathways in Disease
- RNA Interference and Gene Delivery
- Catalytic Alkyne Reactions
- Immune Cell Function and Interaction
- Asymmetric Hydrogenation and Catalysis
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Histone Deacetylase Inhibitors Research
- interferon and immune responses
- Research on Leishmaniasis Studies
- Virus-based gene therapy research
- Chemical Synthesis and Analysis
- Marine Sponges and Natural Products
University of California, Berkeley
2022
Stanford University
2014-2020
Harvey Mudd College
2010
The ability of HIV to establish a long-lived latent infection within resting CD4+ T cells leads persistence and episodic resupply the virus in patients treated with antiretroviral therapy (ART), thereby preventing eradication disease. Protein kinase C (PKC) modulators such as bryostatin 1 can activate these latently infected cells, potentially leading their elimination by virus-mediated cytopathic effects, host's immune response and/or therapeutic strategies targeting actively expressing...
Significance Since the start of HIV/AIDS epidemic, approximately 32 million people have died from infection. Although antiretroviral therapy slows disease progression by preventing virus replication, it does not eliminate latently infected cells, which can resupply active virus, necessitating lifelong treatment. Latency-reversing agents (LRAs), such as protein kinase C (PKC) modulators, present a strategy to cure activating and enabling immunological clearance latent viral reservoirs. A...
Irradiation initiated 1,2-photo Brook rearrangement of acyl silanes generated α-siloxycarbene intermediates that were used for photoaffinity labeling. Optimization the silane group produced a probe capable capturing small molecule–protein interactions.
Safe and effective DNA delivery systems are required to enable or enhance clinical strategies research involving gene therapy vaccinations. To address this problem, a series of charge-altering releasable transporters (CARTs) with varied lipid content were prepared evaluated for plasmid (pDNA) into cultured cells. These lipid-modified CART co-oligomers synthesized in only two steps via sequential organocatalytic ring-opening polymerization lipid-containing cyclic carbonate monomers...
Chikungunya virus (CHIKV) has been spreading rapidly, with over one million confirmed or suspected cases in the Americas since late 2013. Infection CHIKV causes devastating arthritic and arthralgic symptoms. Currently, there is no therapy to treat this disease, only medications focus on relief of Recently, protein kinase C (PKC) modulators have reported inhibit CHIKV-induced cell death assays. The salicylate-derived bryostatin analogues described here are structurally simplified PKC that...
Bryostatin 1 is in clinical trials for the treatment of cancer and Alzheimer's disease a candidate first-in-class approach to HIV/AIDS eradication. It neither readily available nor optimally suited use. Using function oriented synthesis strategy, new class bryostatin-inspired analogs was designed with simplified salicylate-derived subunit, enabling step-economical (23 total steps) agents exhibiting bryostatin-like affinity protein kinase C (PKC).
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus showing recent resurgence and rapid spread worldwide. While vaccines are under development, there currently no therapies to treat this disease, except for over-the-counter (OTC) analgesics, which alleviate the devastating arthritic arthralgic symptoms. To identify novel inhibitors of virus, analogues natural product bryostatin 1, clinical lead treatment cancer, Alzheimer's HIV eradication, were investigated in vitro antiviral activity...