A5027546743- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Diabetes and associated disorders
- Clinical practice guidelines implementation
- Immune Cell Function and Interaction
- DNA and Nucleic Acid Chemistry
- Mathematical and Theoretical Epidemiology and Ecology Models
- Neurobiology of Language and Bilingualism
- HIV-related health complications and treatments
- Gestational Diabetes Research and Management
- Pharmaceutical studies and practices
- Cardiovascular Disease and Adiposity
- Hematopoietic Stem Cell Transplantation
- Systemic Sclerosis and Related Diseases
- Child and Adolescent Health
- HIV, Drug Use, Sexual Risk
- RNA Interference and Gene Delivery
- Anesthesia and Neurotoxicity Research
- Peptidase Inhibition and Analysis
- Cytomegalovirus and herpesvirus research
- Pancreatic function and diabetes
- Economic and Financial Impacts of Cancer
- Primary Care and Health Outcomes
- CRISPR and Genetic Engineering
OhioHealth
2023-2024
Riverside Methodist Hospital
2024
Kingston Hospital
1965-2020
National Institute of Allergy and Infectious Diseases
2012-2017
National Institutes of Health
2010-2017
Peter MacCallum Cancer Centre
2011-2016
University of Toronto
2014
American Physical Therapy Association
2014
Medico
2005
University of South Carolina
2005
There is intense interest in developing curative interventions for HIV. How such a cure will be quantified and defined not known. We applied series of measurements HIV persistence to the study an HIV-infected adult who has exhibited evidence after allogeneic hematopoietic stem cell transplant from homozygous CCR5Δ32 donor. Samples blood, spinal fluid, lymph node, gut were analyzed multiple laboratories using different approaches. No DNA or RNA was detected peripheral blood mononuclear cells...
Sustained suppression of plasma viremia in HIV-infected individuals is attainable with antiretroviral therapy (ART); however, eradication virus that would allow discontinuation ART has been hampered by the persistence HIV reservoirs. It great interest to identify who had received for prolonged periods time extremely low or undetectable reservoirs and monitor following therapy.We measured size CD4(+) T cells on long-term monitored cessation one individual an exceptionally viral burden after a...
Highly active antiretroviral therapy (HAART) decreases plasma viremia below the limits of detection in majority HIV-infected individuals, thus serving to slow disease progression. However, HAART targets only actively replicating virus and is unable eliminate latently infected, resting CD4 + T cells. Such infected cells are potentially capable reinitiating replication upon cessation HAART, leading viral rebound. Agents that would these reservoirs, when used combination with could provide a...
The ability of HIV to establish a long-lived latent infection within resting CD4+ T cells leads persistence and episodic resupply the virus in patients treated with antiretroviral therapy (ART), thereby preventing eradication disease. Protein kinase C (PKC) modulators such as bryostatin 1 can activate these latently infected cells, potentially leading their elimination by virus-mediated cytopathic effects, host's immune response and/or therapeutic strategies targeting actively expressing...
Persistence of the latent viral reservoir has been recognized as a major obstacle to eradicating human immunodeficiency virus (HIV) in infected individuals receiving antiretroviral therapy. It suggested that histone deacetylase inhibitors (HDACis) may purge HIV reservoir. However, effect HDACis on degree and extent expression not fully delineated. Here we demonstrate do induce production aviremic individuals. Therefore, alternative therapeutic strategies be necessary eliminate
Maintenance of HIV latency in vitro has been linked to methylation DNA. However, examinations the degree DNA latently infected, resting CD4(+) T cells infected individuals receiving antiretroviral therapy have limited. Here, we show that 5' long terminal repeat (LTR) latent viral reservoir HIV-infected aviremic is rare, suggesting other mechanisms are likely involved persistence latency.
We studied a cohort of children initiated on treatment doses combination antiretroviral therapy within 72 hours birth. In who achieved sustained virologic suppression, measures HIV-1 reservoir size in peripheral blood were very low.
Elite controllers suppress human immunodeficiency virus (HIV) viremia to below the limit of detection in absence antiretroviral therapy (ART). However, precise frequencies CD4+ T cells carrying replication-competent HIV and/or dynamics infectious viral reservoirs response initiation and discontinuation ART elite are unknown. We show that size pool harboring diminished significantly after rebounded baseline upon cessation therapy. Our data provide compelling evidence persistent replication...
Purpose: To explore communication-related experiences with accessing and participating in community-based exercise programmes from the perspective of adults post-stroke aphasia. Methods: Adults mild to severe aphasia were recruited Aphasia Institute (AI), Toronto, Canada, for a qualitative descriptive study using semi-structured, in-depth one-on-one interviews. Participants asked identify facilitators of, barriers to, strategies joining programmes. Interview data analyzed conventional...
Lean improvement methodology provided a framework for improved understanding and management of system constraints within CDU, resulting in access to treatment reduced waiting times.
<h3>Background</h3> Insulin is a high-risk medicine which may cause significant patient harm or death when given incorrectly. A 10-fold error in administered insulin dose commonly occurs the abbreviation ‘u’ used for ‘units’ and subsequently misinterpreted as ‘zero.’ <h3>Method</h3> multidisciplinary working party was convened mapped prescribing, dispensing administration. All inpatient orders above 25 units short-acting 50 other require validation by an additional source. Educational...
Recent studies have shown improved outcomes with the initiation of earlier subcutaneous (SQ) basal insulin. The purpose this study was to examine effects early SQ insulin administration on hospital length stay in patients mild moderate diabetic ketoacidosis (DKA).
These guidelines, informed by the best available evidence and consensus expert opinion, provide a framework to guide timely initiation of chemotherapy for treating cancer. They sit at intersection patient experience, state-of-the-art disease management rational efficient service provision these patients system level. Internationally, cancer waiting times are routinely measured publicly reported. In Australia, there existing policies guidelines relating timeliness care surgery radiation...
Background Gay and other men who have sex with of Asian background (GAM) been identified as a key population in efforts to eradicate HIV New South Wales. The aims the present study were evaluate current levels engagement sexually transmissible infection (STI) testing services, assess knowledge pre- post-exposure prophylaxis identify factors associated service this group. Methods: A survey 604 GAM residing Sydney Melbourne was undertaken. Results: data that significant proportion...
Availability of integrase strand transfer inhibitors created interest in determining whether their use would decrease persistently infected cell numbers. This study hypothesized that adding raltegravir (RAL) to standard antiretroviral therapy (ART) human immunodeficiency virus (HIV)-infected CD4(+) T cells more than combination ART. was a pilot, randomized comparing open-label triple ART plus RAL over 96 weeks ART-naive adults with early HIV infection. The primary objective compare quantity...
Abstract Aim Variation in dose‐timing within multiday chemotherapy regimens is largely unknown with convention being to administer subsequent days of treatment at 24‐h intervals. However, reality there are many occasions where doses given either earlier or later accommodate a variety clinical and operational priorities. This project aimed evaluate the degree existing variation investigate whether deliberate could improve quality efficiency outcomes such as reduction after hours...
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