A5080324507- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV Research and Treatment
- Bacterial Infections and Vaccines
- HIV, Drug Use, Sexual Risk
- Infectious Encephalopathies and Encephalitis
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Adolescent Sexual and Reproductive Health
- Global Maternal and Child Health
- Gestational Diabetes Research and Management
- Travel-related health issues
- HIV/AIDS drug development and treatment
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- COVID-19 Impact on Reproduction
- Pregnancy and Medication Impact
- Mosquito-borne diseases and control
- Malaria Research and Control
- Herpesvirus Infections and Treatments
- Healthcare Systems and Technology
- Breastfeeding Practices and Influences
- Parvovirus B19 Infection Studies
- Neonatal and Maternal Infections
University of Ottawa
2016-2025
Children's Hospital of Eastern Ontario
2016-2025
Ottawa Hospital
2023
Clinton Health Access Initiative
2018-2023
HIV Legal Network
2022
Office of Infectious Diseases
2021
University of British Columbia
2018
B.C. Women's Hospital & Health Centre
2018
Centre Hospitalier Universitaire Sainte-Justine
2018
Université de Montréal
2018
OBJECTIVES: The pathogens that cause bacterial meningitis in infants and their antimicrobial susceptibilities may have changed this era of increasing resistance, use conjugated vaccines, maternal antibiotic prophylaxis for group B Streptococcus (GBS). objective was to determine the optimal empirical antibiotics early infancy. METHODS: This a cohort study <90 days age with at 7 pediatric tertiary care hospitals across Canada 2013 2014. RESULTS: There were 113 patients diagnosed proven...
We studied a cohort of children initiated on treatment doses combination antiretroviral therapy within 72 hours birth. In who achieved sustained virologic suppression, measures HIV-1 reservoir size in peripheral blood were very low.
Abstract We describe a case of blastomycosis in an 8-year-old boy with Blastomyces-associated osteomyelitis and possible pulmonary involvement. also identify 309 cases Ontario that were seen during 10-year period, 57% which occurred from 2001 to 2003. The overall incidence the study period was 0.30 per 100,000 population. Most patients north (n = 188), where 2.44 100,000. Toronto region 0.29 Thirteen percent children <19 years age. These findings substantially increase number known Canada....
We describe the presenting features and long-term outcome of an unusual cluster pediatric acute flaccid paralysis cases that occurred in Canada during 2014 enterovirus D68 outbreak. Children (n = 25; median age 7.8 years) to Canadian centers between July 1 October 31, 2014, who met diagnostic criteria for were evaluated retrospectively. The predominant included prodromal respiratory illness 22), cerebrospinal fluid lymphocytic pleocytosis 18), pain neck/back 14) extremities 10),...
Background Champlain BASE™ (Building Access to Specialists through eConsultation) is a web-based asynchronous electronic communication service that allows primary-care- practitioners (PCPs) submit “elective” clinical questions specialist. For adults, PCPs have reported improved access and timeliness specialist advice, averted face-to-face referrals in up 40% of cases high provider satisfaction. Objective To determine whether the expansion eConsult pediatric setting would result similar...
The goal of antiretroviral therapy (ART) is to suppress HIV-1 replication and reconstitute CD4+ T cells. Here, we report on HIV-infected individuals who had a paradoxical decline in cells despite ART-mediated suppression plasma load (pVL). We defined such an immunological outcome as extreme immune (EXID).
Dolutegravir is recommended worldwide as a first-line antiretroviral therapy (ART) for individuals living with HIV. A recent study reported increased rates of neural tube defects in infants dolutegravir-treated women. This examined congenital anomalies born to women HIV (WLWH) Canada.The Canadian Perinatal Surveillance Programme captures surveillance data on pregnant WLWH and their babies was analysed examine the incidence anomalies.Paediatric clinics.Live-born Canada between 2007 2017.Data...
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Background: Breastfeeding is not recommended for women living with HIV (WLWH) in Canada. We described the prevalence of breastfeeding and explored experiences care, support, stigma related to infant feeding. Setting: Quebec, Ontario, British Columbia (Canada). Methods: Data were obtained from Women's Sexual Reproductive Health Cohort Study (CHIWOS) surveys, conducted between 2013 2018. Results: was reported by 73.5% 786 who delivered before diagnosis 7.3% 289 after diagnosis. Among them,...
Lyme neuroborreliosis is a tick-borne illness with central and peripheral nervous system manifestations. Clinical features methods for accurate diagnosis differ across world regions owing to different causative Borrelia species. The importance of these distinctions highlighted by 12-year-old Canadian girl who acquired in Europe.
Background Although antiretroviral therapy during pregnancy is associated with significant reductions in the risk of vertical transmission HIV, attainment this outcome highly treatment-experienced pregnant women might be complicated by lack active drugs available to assemble a potent regimen. The recent licensing and availability darunavir, etravirine raltegravir has broadened management options for patients. However, data on their safety efficacy preventing are limited. Methods A...
HOWDose, schedule, contraindications and precautions, co-administration.Children who have been previously immunized with seasonal influenza vaccine adults are to receive one dose of each year.Children 6 months <9 years age receiving for the first time should be given two doses, a minimum interval four weeks between doses.The route administration dosage varies by product (See section IV.3 this statement details).For intramuscular TIV, is now 0.5 ml all groups.Persons developed an anaphylactic...
Mutations of FBXL4, which encodes an orphan mitochondrial F-box protein, are a recently identified cause encephalomyopathic mtDNA depletion. Here, we describe the detailed clinical and biochemical phenotype neonate presenting with hyperlactatemia, leukoencephalopathy, arrhythmias, pulmonary hypertension, dysmorphic features, lymphopenia. Next-generation sequencing in proband homozygous frameshift, c.1641_1642delTG, surrounding block SNP marker homozygosity by microarray. Muscle biopsy showed...
Background: In Canada, pertussis is an endemic and cyclical disease, with peaks occurring at two-to five-year intervals.Although incidence varies by age group, unvaccinated or undervaccinated infants are greatest risk of infection associated complications.Since the last National Advisory Committee on Immunization (NACI) recommendations published in 2014, new evidence safety effectiveness tetanus toxoid, reduced diphtheria toxoid acellular (Tdap) vaccine administration pregnancy has become...
Objectives Combination antiretroviral therapy has largely restored the lifespan of persons living with HIV. Data suggest early comorbidities aging in this population. Past studies focused on men; limited data exist regarding prevalence dyslipidaemia women HIV (WLWH). We investigated cardiometabolic abnormalities among WLWH and HIV‐negative Children Women: Antiretrovirals Markers Aging (CARMA) cohort, their relationships to cellular markers. Methods conducted a cross‐sectional analysis...
The standard of care for the prevention vertical transmission (VT) HIV in Canada and other developed countries includes routine prenatal testing all pregnant women, those positive: antepartum combination antiretroviral therapy (cART); intrapartum intravenous zidovudine; six weeks postnatal oral zidovudine to infant; exclusive formula feeding infant. With these interventions, rate VT has been reduced from 25% 40%, 4 before delivery. purpose present article is highlight recent changes...
<h3>Background:</h3> Vertical HIV transmission has declined in Canada, but missed opportunities for prevention continue to occur. We sought determine the adequacy, and changes over time of uptake maternal neonatal antiretroviral therapy vertical transmission, rate according adequacy antenatal during combination era Canada. <h3>Methods:</h3> The Canadian Perinatal Surveillance Program collects data annually through retrospective chart review concerning HIV-infected women their infants....