A5040108856- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Ion channel regulation and function
- Reproductive Biology and Fertility
- Biochemical effects in animals
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- ATP Synthase and ATPases Research
- Photosynthetic Processes and Mechanisms
- Cancer Risks and Factors
- Meat and Animal Product Quality
- Ovarian function and disorders
- Drug Transport and Resistance Mechanisms
- Cardiac Ischemia and Reperfusion
- Mass Spectrometry Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Electrochemical Analysis and Applications
- Clinical Reasoning and Diagnostic Skills
- Molecular Sensors and Ion Detection
- Chemical Thermodynamics and Molecular Structure
- Catalysis and Oxidation Reactions
- thermodynamics and calorimetric analyses
- Cancer Treatment and Pharmacology
- Lipid Membrane Structure and Behavior
Florida Institute of Technology
2024
University of California, San Francisco
2016-2023
NHS Blood and Transplant
2019
University of Washington
2005-2018
Cooper University Hospital
2007
Rutgers Cancer Institute of New Jersey
2007
Kaiser Permanente
2005
Group Health Cooperative
2005
University of Glasgow
2005
HealthPartners
2005
Mevinolin, a fungal metabolite, was isolated from cultures of Aspergillus terreus. The structure and absolute configuration mevinolini its open acid form, mevinolinic acid, were determined by combination physical techniques. Mevinolin shown to be 1,2,6,7,8,8a-hexahydro-beta, delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthalene-hepatanoic delta-lactone. in the hydroxy-acid is potent competitive inhibitor 3-hydroxy-3-methylglutaryl-coenzyme A reductase [mevalonate: NADP+...
Investigations of the effects valinomycin on mitochondria" 2 led to dis- covery antibiotic-mediated ion transport.3Subsequent work revealed that this property is shared by valinomycin, enniatins, macrolide actins, and gramicidins, including an extensive array natural synthetic analogues.4-6Passive permeability have been reported obtained with these agents other systems erythroeytes,7 lipid vesicles,7 artificial bi- molecular leaflets.8' 9The actins can even mediate cation trans-
1. Total water exchangeable with tritiated and sucrose space were measured in rat liver mitochondria during the uptake of K(+) induced by valinomycin release caused nigericin. The content sucrose-inaccessible rose fell together. 2. Swelling resulting from phosphate addition a medium high concentration was associated mainly increased sucrose-accessible water, which carried dissolved K(+). This change reversed ATP. 3. response to changed osmolarity qualitatively that expected if mitochondrial...
The action of Ba(++) on membrane potential (E(m)) and resistance (R(m)) frog (R. pipiens) sartorius fibers was studied. In normal Cl(-) Ringer's, (<9 mM) did not depolarize or induce contractions, but increased R(m) slightly above the control value 3.8 +/- 0.6 K ohm-cm(2). Cl(-)-free Ringer's (methane sulfonate) 28.8 2.8 ohm-cm(2), low concentrations (0.05-5.0 depolarized induced spontaneous contractions (fibrillation), even in tetrodotoxin. To stop disturbance microelectrodes, were...
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStimulation of Mitochondrial Respiration and Phosphorylation by Transport-Inducing Antibiotics*E. J. Harris, M. P. Höfer, B. C. PressmanCite this: Biochemistry 1967, 6, 5, 1348–1360Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 1967https://doi.org/10.1021/bi00857a018RIGHTS & PERMISSIONSArticle Views76Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full...
Respiring rat heart mitochondria were loaded with Ca2+ and then treated Ruthenium Red. The factors affecting the subsequent Ca2+-efflux studied. Addition of rotenone or antimycin led to a decline efflux except at pH values above 7.2, provided load was less than about 80 nmol per mg protein. Oligomycin reversed effect respiratory inhibitors. Independently respiration, stimulated by uncoupler trifluoromethyltetrachlorbenzimadazole, mersalyl thyroid hormones. could be diminished ADP, Mg2+ as...
The movements of tracer K and net changes have been measured in frog muscle. quantities moving can be linearly related to the square root time after a delay 4 30 minutes depending on external concentration. slope uptake-t((1/2)) line is increased when concentration raised. Q(10) uptake about 1.9 per unit t((1/2)). from 1 2 mM diminished by factor if strophanthin applied. output t((1/2)) 1.4 strophanthin. Tetrabutylammonium substituted for 10 cent Na medium causes reversible slowing output....
Organic peroxides are formed during the combustion of hydrocarbons (Callendar 1927; Egerton Mondain Monval and Quanquin 1929), they have been shown to be very powerful "proknock" substances (Egerton, Smith Ubbelohde 1935). The work Townend (1933-8) has that lower ignition region is which characterizes their "knock" behaviour. In this there appear only stable within a certain range temperature it those seem determine knock behaviour (Egerton 1928; Neumann Aivazov It quite likely peroxides,...
When heart or liver mitochondria are exposed to superoxide radicals generated from xanthine + oxidase their ability take up and retain Ca 2+ is impaired. The rate of oxidation pyruvate malate as substrates diminished the appearance thiol groups when supplied with these abolished. These inhibitory effects offset if respiration supported by succinate in presence rotenone provided that a substrate (β‐hydroxybutyrate) maintain reduction NADH. data agree thesis generation essential membrane...
1. The concentration-dependence of the intramitochondrial accumulation l-malate and succinate was measured expressed in form adsorption isotherms. accumulation, however, may arise because an internal positive potential. 2. competition for offered by some other anions, including phosphate, is conventionally additional terms equation. 3. interactions between anions were also studied when one acting as oxidized substrate. 4. In examples there a parallel effects added anion on both oxidation;...
In a previous paper (Harris and Egerton 1938) the results of an investigation decomposition diethyl peroxide have been published. The present communication deals with related compounds ( ) dipropyl peroxide, which closely resembles compound as it decomposes unimolecularly, b ethyl hydrogen (c) propyl peroxide. two latter decompose heterogeneously at lower temperatures, while higher temperatures they luminously in absence added oxygen. Dipropyl does not appear to mentioned literature; was...