A5066156984- Biochemical Analysis and Sensing Techniques
- Infant Nutrition and Health
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Genetic factors in colorectal cancer
- Pancreatic function and diabetes
- Inflammatory Bowel Disease
- Immune responses and vaccinations
- Advanced Chemical Physics Studies
- Immune Response and Inflammation
- Tryptophan and brain disorders
- Genetics, Aging, and Longevity in Model Organisms
- PI3K/AKT/mTOR signaling in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Microtubule and mitosis dynamics
- Melanoma and MAPK Pathways
- Long-Term Effects of COVID-19
- Zebrafish Biomedical Research Applications
- Cellular Mechanics and Interactions
- Molecular Spectroscopy and Structure
- Cancer Cells and Metastasis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Colorectal Cancer Treatments and Studies
- Antifungal resistance and susceptibility
- Lung Cancer Treatments and Mutations
Center for Neurosciences
2024-2025
New York State Office for People With Developmental Disabilities
2024-2025
University of North Carolina at Chapel Hill
2023-2025
Hallym University
2023-2024
Duke University
2016-2024
Dongduk Women's University
2024
University of Wisconsin–Madison
2020
Yonsei University
2014-2019
Pusan National University
2014
Adenomatous polyposis coli ( APC ) loss-of-function mutations and K-Ras gain-of-function are common abnormalities that occur during the initiation intermediate adenoma stages of colorectal tumorigenesis, respectively. However, little is known about role these play in cancer stem cells (CSCs) associated with (CRC) tumorigenesis. We analyzed tissue from CRC patients (n = 49) to determine whether contributed CSC activation DLD-1-K-Ras-WT DLD-1-K-Ras-MT were cultured evaluated for their ability...
Invadopodia are specialized membrane protrusions composed of F-actin, actin regulators, signaling proteins, and a dynamically trafficked invadopodial that drive cell invasion through basement (BM) barriers in development cancer. Due to the challenges studying vivo, mechanisms controlling invadopodia formation their native environments remain poorly understood. We performed sensitized genome-wide RNAi screen identified 13 potential regulators during anchor (AC) into vulval epithelium C....
Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized conserved population highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has been shown to enhance nutrients, such as lipids, by intestinal epithelial cells. However, whether is also affected poorly understood. Here, we investigate connections between microbes zebrafish gut. Using live microscopy-based quantitative assays, find that slow pace uptake degradation LREs. While do...
Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized conserved population highly absorptive lysosome-rich enterocytes (LREs). The gut microbiome has been shown to enhance nutrients, such as lipids, by intestinal epithelial cells. However, whether is also affected poorly understood. Here, we investigate connections between microbes zebrafish gut. Using live microscopy-based quantitative assays, find that slow pace uptake degradation LREs. While do...
Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized conserved population highly absorptive lysosome-rich enterocytes (LREs). The gut microbiome has been shown to enhance nutrients, such as lipids, by intestinal epithelial cells. However, whether is also affected poorly understood. Here, we investigate connections between microbes zebrafish gut. Using live microscopy-based quantitative assays, find that slow pace uptake degradation LREs. While do...
Drugs targeting the epidermal growth factor receptor (EGFR), such as cetuximab and panitumumab, have been prescribed for metastatic colorectal cancer (CRC), but patients harboring KRAS mutations are insensitive to them do not an alternative drug overcome problem. The levels of β-catenin, EGFR, RAS, especially mutant KRAS, increased in CRC patient tissues due adenomatous polyposis coli (APC), which occur 90% human CRCs. increases these proteins by APC loss synergistically promote...
Abstract The epidermal growth factor receptor (EGFR) inhibitors such as erlotinib and gefitinib are widely used for treatment of non-small cell lung cancer (NSCLC), but they have shown limited efficacy in an unselected population patients. KRAS mutations, which identified approximately 20% NSCLC patients, to be associated with the resistance EGFR tyrosine kinase (TKIs). Currently, there is no clinically available targeted therapy can effectively inhibit tumors harboring mutations. This study...
The host innate immune system has developed elegant processes for the detection and clearance of invasive fungal pathogens. These strategies may also aid in spread pathogens vivo, although technical limitations have previously hindered our ability to view endothelial cells probe their roles spreading disease. Here, we leveraged zebrafish larvae as a model interactions these with pathogen Candida albicans vivo. We examined three potential host-mediated mechanisms spread: movement inside...
Inflammatory Bowel Diseases (IBD) are chronic inflammatory conditions influenced heavily by environmental factors. DNA methylation is a form of epigenetic regulation linking stimuli to gene expression changes and inflammation. Here, we investigated how the
Abstract Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized conserved population highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has been shown to enhance nutrients, such as lipids, by intestinal epithelial cells. However, whether is also affected poorly understood. Here, we investigate connections between microbes zebrafish gut. Using live microscopy-based quantitative assays, find that slow pace uptake degradation LREs....
살리실산 유도체의 멜라닌 억제효과 및 미백효과: ethyl 2-(hexyloxy) benzoate, hexyl benzoate
Keywords: Cell-free DNA, sepsis, oxidative stress, immunoredox modulation, cecal ligation and puncture, toll-like receptor
Abstract The host innate immune system has developed elegant processes for the detection and clearance of invasive fungal pathogens. These strategies may also aid in spread pathogens vivo , although technical limitations have previously hindered our ability to view endothelial cells probe their roles spreading disease. Here, we leveraged zebrafish larvae as a model interactions these with pathogen Candida albicans . We examined three potential host-mediated mechanisms spread: movement inside...
Abstract Although the neuroinvasiveness of SARS-CoV-2 has been extensively studied, correlation between virus infectivity and brain maturation remained unclear. Here, using human-induced pluripotent stem cells-derived three-dimensional cerebral organoids (CBOs), we present first quantitative data for long-term kinetics propagation in 20 days post-infection. We showed that mature brains are more susceptible to than immature counterparts, evident from increased viral replication rate higher...