A5024674943- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac pacing and defibrillation studies
- Aortic aneurysm repair treatments
- Frailty in Older Adults
- Congenital Heart Disease Studies
- Hip and Femur Fractures
- Cardiac tumors and thrombi
- Cardiac Arrest and Resuscitation
- Soft Robotics and Applications
- Tracheal and airway disorders
- Tissue Engineering and Regenerative Medicine
- Cardiac Arrhythmias and Treatments
- Streptococcal Infections and Treatments
- Advanced X-ray and CT Imaging
- Orthopaedic implants and arthroplasty
- Vascular Procedures and Complications
Charité - Universitätsmedizin Berlin
2018-2025
Deutsches Herzzentrum der Charité
2016-2025
German Centre for Cardiovascular Research
2017-2025
Freie Universität Berlin
2020-2025
Humboldt-Universität zu Berlin
2020-2025
Berlin Heart (Germany)
2016-2022
Auguste-Viktoria-Klinik
2022
Deutsches Herzzentrum München
2017-2021
Orthopädische Universitätsklinik
2020
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020
Objective: Cardiosurgical operative risk can be assessed using the logistic European system for cardiac evaluation (EuroSCORE) and Society of Thoracic Surgeons (STS) score. Factors other than medical diagnoses laboratory values such as 'biological age' are not included in these scores. The aim study was to evaluate an additional assessment frailty routine surgical practice. Methods: 'The comprehensive frailty' test applied 400 patients ≥74 years who were admitted our centre between September...
Assessment of perioperative risk elderly patients in cardiac surgery is difficult, and most the common scores show over- or underestimation. Two frailty scores, comprehensive assessment (CAF) score Frailty predicts death One yeaR after CArdiac Surgery Test (FORECAST), were developed as additional tools to estimate preoperative mortality risk, taking into consideration status patients.Four hundred fifty who referred for elective included. All assessed with CAF test FORECAST. Thirty-day 1-year...
Background— Turbulent kinetic energy (TKE), assessed by 4-dimensional (4D) flow magnetic resonance imaging, is a measure of loss in disturbed as it occurs, for instance, aortic stenosis (AS). This work investigates the additional information provided quantifying TKE assessment AS severity comparison to clinical echocardiographic measures. Methods and Results— Fifty-one patients with (67±15 years, 20 female) 10 healthy age-matched controls (69±5 5 were prospectively enrolled undergo...
Minimally invasive surgical mitral valve repair (MVRepair) has become routine for the treatment of regurgitation, and indications have been expanded to include reoperations. Current European Society Cardiology/European Association Cardio-Thoracic Surgery guidelines management valvular heart disease recommended standards in terms differentiation, timing intervention techniques improve patient care. Numerous minimally lessen invasiveness described, such as minimal-access J-sternotomy...
The EchoNavigator (EN) software (Philips Healthcare, Best, Netherlands) enables real-time fusion of echocardiography and fluoroscopy by co-registration the probe on x-ray image. We aimed to evaluate feasibility safety this novel during MitraClip procedures.Twenty-one patients were treated with support (EN+ patients). primary (safety) endpoint was total radiation dose. Secondary endpoints procedure time. measurements compared those 21 immediately before installation (EN- More MitraClips (45...
Abstract Cardiothoracic open‐heart surgery has revolutionized the treatment of cardiovascular disease, leading cause death worldwide. After surgery, hemodynamic and volume management can be complicated, for example in case vasoplegia after endocarditis. Timely is crucial outcomes. Currently, decisions are made based on heart volume, which needs to measured manually by clinician each time using ultrasound. Alternatively, implantable sensors offer a real‐time window into dynamic function our...
A novel hybrid non-covered stent was developed to treat malperfusion and prevent aneurysm formation following hemiarch procedure for DeBakey I acute aortic dissection (AAD). The present analysis investigates the performance of device in 100 consecutive implantations.Between 2018 2021, patients underwent surgical repair AAD with implantation a arch descending aorta. primary entry tear located root or ascending Clinical imaging data were collected analysed retrospectively. endpoints study...
Abstract OBJECTIVES This study investigates early and midterm outcomes after surgery for acute DeBakey type I dissection between classic hemiarch replacement or additional open noncovered stenting of the aortic arch. METHODS Patients who underwent receiving solely (2015–2022) arch (2018–2022) using “Ascyrus Medical Dissection Stent” (AMDS) were included. After propensity score matching, groups compared in terms clinical radiological outcomes. RESULTS A total 261 patients (155 hemiarch, 106...
Background: Transcatheter aortic valve replacement (TAVR) has emerged as a well-established option for patients with severe stenosis who present high or extreme surgical risk. Direct comparisons of outcomes between different prostheses are important to assist operators in making an informed device selection. We aimed perform comparative analysis early clinical at 30 days and long-term up 3 years after TAVR using self-expandable Portico CoreValve Evolut R prostheses. Methods: Out 396 treated...
Background: Transcatheter aortic valve implantation (TAVI) is the treatment of choice for symptomatic stenosis in patients with moderate to high surgical risk. When transfemoral access unsuitable, alternative routes such as transapical (TAP) or transaxillary (TAX) must be considered. This study compares in-hospital mortality and clinical outcomes TAP vs. TAX TAVI. Methods: We conducted a retrospective analysis 76 who underwent TAVI between 2018 2021 at our department. Inverse probability...
Introduction: The integration of the “heart team” (HT) concept has become essential in managing complex cardiovascular diseases,. Initially, decisions on CAD treatment were predominantly made by cardiologists or cardiac surgeons. However, increasing complexity patient data and publication milestone studies underscored need for an interdisciplinary approach. HT approach, which first gained traction Dutch hospitals late 1990s, since been endorsed European guidelines, highlighting its...
Heart failure (HF), obesity and diabetes are associated with structural functional changes that affect the heart at both organ cellular levels. Studying isolated adult single cardiomyocytes provides valuable mechanistic insights. However, isolating from human tissue is particularly challenging. This study presents an optimized multiple-step digestion protocol to isolate viable atrial ventricular obtained peri-operatively or through myocardial biopsies. Using this method & resource, we...
Less-invasive techniques for cardiothoracic surgical procedures are designed to limit trauma, but the technical requirements and preoperative planning more demanding than those conventional sternotomy. Patient selection, interdisciplinary collaboration, skills key factors procedural success. Aortic valve replacement is frequently performed through an upper hemisternotomy, right anterior minithoracotomy represents even less traumatic, advancement. Preoperative assessment of ascending aorta in...
prediction tool for early mortality after cardiac surgery .
Tissue replacement is sometimes necessary during surgery for endocarditis. Commonly used materials are Dacron, expanded polytetrafluoroethlyene, or bovine pericardium. Those have no potential bioresorption and cannot restore regional functionality. Extracellular matrices became available lately as patch material. Here we present two cases of patients with CorMatrix ECM (CorMatrix Cardiovascular, Inc., Atlanta, Georgia, United States) was to repair intracardiac structures good results in...
Transcatheter aortic valve implantation (TAVI) is a minimally invasive off-pump procedure to replace diseased heart valves. Known complications include paravalvular leaks, atrioventricular blocks, coronary obstruction and annular rupture. Careful planning including appropriate stent selection sizing are crucial. Few patient-specific geometric parameters, like diameters, perimeter measurement of the distance ostia, currently used within this process. Biomechanical simulation allows...