A5060904225- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Sesquiterpenes and Asteraceae Studies
- Synthetic Organic Chemistry Methods
- Synthesis and biological activity
- Microbial Natural Products and Biosynthesis
- Synthesis of heterocyclic compounds
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Pediatric health and respiratory diseases
- Chemical synthesis and alkaloids
- Asymmetric Synthesis and Catalysis
- Phytochemistry and Biological Activities
- Plant Toxicity and Pharmacological Properties
- Chemical Synthesis and Reactions
- Analytical Chemistry and Chromatography
- Fungal Plant Pathogen Control
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and Characterization of Pyrroles
- Axial and Atropisomeric Chirality Synthesis
- Carbohydrate Chemistry and Synthesis
- Plant biochemistry and biosynthesis
- Click Chemistry and Applications
- Organic and Inorganic Chemical Reactions
- Synthesis and Reactivity of Sulfur-Containing Compounds
Novosibirsk Institute of Organic Chemistry
2014-2025
Novosibirsk State University
2012-2025
Russian Academy of Sciences
2012-2017
Xanthine derivatives have been a great area of interest for the development potent bioactive agents. Thirty-eight methylxanthine as acetylcholinesterase inhibitors (AChE) were designed and synthesized. Suzuki–Miyaura cross-coupling reactions 8-chlorocaffeine with aryl(hetaryl)boronic acids, CuAAC reaction 8-ethynylcaffeine several azides, copper(I) catalyzed one-pot three-component (A3-coupling) 8-ethynylcaffeine, 1-(prop-2-ynyl)-, or 7-(prop-2-ynyl)-dimethylxanthines formaldehyde secondary...
Background: Natural sesquiterpene lactones are an important class of heterocyclic compounds in drug discovery since they possess a wide range biological properties, including antibacterial activity. Objective: The objective this study was to synthesize isoalantolactone derivatives with furo[2,3-d] pyrimidin-2-оne moiety, and evaluate their antiviral Methods: Sonogashira cross-coupling subsequent Ag-catalyzed cyclization reactions were used forthe synthesis. activity the ability inhibit...
РезюмеЦель.Изучение антибактериальных свойств изоалантолактона и его производных в отношении условно-патогенных бактерий
Introduction. The resistance of microbes to many classes antimicrobial drugs is a global threat human health and necessitates the search for new compounds with activity, low toxicity potentially wide range biological activity. Aim. To study in vitro ability xanthine derivatives (caffeine, 1-butyltheobromine 7-butyltheophylline) inhibit growth Staphylococcus (S.) aureus, Bacillus (B.) cereus, Escherichia (E.) coli Pseudomonas (P.) aeruginosa. Materials methods. antibacterial activity...
Screening for the antitumor potency of novel derivatives isoalanotlactone revealed: (1) compound pat_651p, demonstrating high selectivity action in respect to tumor cells and triggering oxidative stress mitochondrial-dependent apoptosis them; (2) pat_651_6p capable passing through blood-brain barrier effectively inhibiting motility, invasion, adhesive traits glioblastoma multiforme cells.