A5051537120- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Energetic Materials and Combustion
- Thermal and Kinetic Analysis
- Metal-Catalyzed Oxygenation Mechanisms
- Synthesis and Catalytic Reactions
- Chemical Reaction Mechanisms
- Porphyrin and Phthalocyanine Chemistry
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Crystallography and molecular interactions
- Synthesis and biological activity
- Oxidative Organic Chemistry Reactions
- Asymmetric Hydrogenation and Catalysis
- Chemical Reactions and Mechanisms
- Synthesis and bioactivity of alkaloids
- Analytical Chemistry and Chromatography
- Organic and Inorganic Chemical Reactions
- Synthesis of heterocyclic compounds
- Cancer therapeutics and mechanisms
- Fluorine in Organic Chemistry
- bioluminescence and chemiluminescence research
- Drug Solubulity and Delivery Systems
- Synthesis of Tetrazole Derivatives
Novosibirsk State University
2015-2024
Novosibirsk Institute of Organic Chemistry
2015-2024
Russian Academy of Sciences
2012-2023
Siberian Branch of the Russian Academy of Sciences
2016-2023
Universität Hamburg
2022
ShanghaiTech University
2019
University of Amsterdam
2019
Nanjing University of Science and Technology
2019
Universidad de Murcia
2019
Sichuan University
2019
Azole antifungals, including fluconazole, have long been the first-line antifungal agents in fight against fungal infections. The emergence of drug-resistant strains and associated increase mortality from systemic mycoses has prompted development new based on azoles. We reported a synthesis novel monoterpene-containing azoles with high activity low cytotoxicity. These hybrids demonstrated broad-spectrum all tested strains, excellent minimum inhibitory concentration (MIC) values both...
Direct oxygenation of nonactivated aliphatic C(sp3)-H groups with peroxycarboxylic acids in the presence palladium tris(pyridylmethyl)amine complex (0.6 mol %) is reported, providing corresponding hydroxylated derivatives up to 94% yields. The oxidation 3° C-H occurs stereospecifically, catalyst system demonstrating extremely high sensitivity electronic effects (adamantane oxidation: 3°:2° >300). This suggests potential applications for 3°-regioselective oxidative functionalization molecules...
Co-crystals of pharmaceutical compounds are widely used to improve the properties drug formulations, such as dissolution behavior, bioavailability, or tabletability. The main methods their synthesis include co-crystallization from solution, melt, cogrinding. Only a few examples have been documented when co-crystals obtained by freeze-drying, namely, in systems where components target co-crystal had similar aqueous solubilities. This work illustrates potential freeze-drying for obtaining...
Abstract Alkaloid quindoline, its structural analogues and δ‐carbolines were obtained through the Cadogan reaction using DPPE under solvent‐free conditions as a key stage of synthesis. Various o ‐nitroarylpyridines prepared by one‐pot synthesis from nitroacetophenones, methyl orthoformate acetoacetic ester enamine used starting materials for preparation δ‐carbolines. 2‐Aryl‐3‐nitro‐5,6,7,8‐tetrahydroquinolines reacting 2‐hydroxymethylenecyclohexanone with nitroacetophenones enamines...
Cadogan reductive cyclization of substituted 2-aryl-3-nitropyridines to give δ-carbolines was performed under MoO2Cl2(DMF)2 catalysis with triphenylphosphine as a ligand. A new approach for the synthesis alkaloid quindoline based on Mo(VI)-catalyzed 2-phenyl-3-nitro-5,6,7,8-tetrahydroquinoline followed by aromatization resulting 2,3,4,10-tetrahydro-1H-indolo[3,2-b]quinoline is proposed. Various о-nitroarylpyridines, obtained reacting acylpyruvates and cyclic hydroxymethylene ketones...
A new approach is suggested herein for the synthesis of pyrazole derivatives by reacting 4-nitrosemicarbazide with acetylacetone. Additional studies were done on reaction acetylacetone semicarbazide and its (4-aminosemicarbazide, methylsemicarbazide, dimethylsemicarbazide). The study resulted in monocyclic 3,5-dimethyl-N-nitropyrazole-1-carboxamide, 5-hydroxy-3,5-dimethyl-2-pyrazoline, bicyclic bis(3,5-dimethylpyrazole-1-carbonyl)hydrazine, conditions formation acetone semicarbazone...
A key step in the reaction mechanism is addition of SO<sub>2</sub> to superelectrophilic intermediates – protonated phenanthrenium cations.