A5013284945- Synthesis and Biological Evaluation
- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Silicone and Siloxane Chemistry
- Electrospun Nanofibers in Biomedical Applications
- Synthesis and properties of polymers
- Recycling and Waste Management Techniques
- Horticultural and Viticultural Research
- Dyeing and Modifying Textile Fibers
- Cardiac Valve Diseases and Treatments
- Extraction and Separation Processes
- Fermentation and Sensory Analysis
- Agriculture and Biological Studies
- Metallurgy and Cultural Artifacts
- Agricultural Productivity and Crop Improvement
- Medical and Biological Sciences
- RNA modifications and cancer
- Eurasian Exchange Networks
- Epigenetics and DNA Methylation
- DNA and Nucleic Acid Chemistry
- Orthopaedic implants and arthroplasty
- Microplastics and Plastic Pollution
- Epoxy Resin Curing Processes
- Archaeology and ancient environmental studies
- Inorganic Fluorides and Related Compounds
Novosibirsk Institute of Organic Chemistry
2014-2024
Siberian Branch of the Russian Academy of Sciences
2010-2024
Novosibirsk State University
2010-2019
Ministry of Health of the Russian Federation
2019
Russian Academy of Sciences
1990-2018
Novosibirsk Tuberculosis Research Institute
2016
University of Leicester
2012-2014
Lomonosov Moscow State University
2011
Keele University
2010
Institute of Cytology
1990-2007
Prader-Willi syndrome (PWS [MIM 176270]) is a neurogenetic disorder characterized by decreased fetal activity, muscular hypotonia, failure to thrive, short stature, obesity, mental retardation, and hypogonadotropic hypogonadism. It caused the loss of function one or more imprinted, paternally expressed genes on proximal long arm chromosome 15. Several potential PWS mouse models involving orthologous region 7C exist. Based analysis deletions in gene expression patients with chromosomal...
The tumour suppressor p53 is a crucial regulator of cell cycle arrest and apoptosis by acting as transcription factor to regulate variety genes. At least in part, this control exerted via regulating expression numerous microRNAs. We identified two abundantly expressed microRNAs, miR-16 miR-26a, whose regulated during the checkpoint induced genotoxic drug, doxorubicin. Importantly, among targets these miRs are critical kinases, Chk1 Wee1. p53-dependent augmentation miR-26a levels led cells...
(1R,2R,6S)-3-Methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possesses potent antiparkinsonian activity in both MPTP and haloperidol animal models. The use of compound resulted nearly full recovery the locomotor exploratory activities was as effective comparator agent (levodopa). All eight stereoisomers have been synthesized influence absolute configuration on shown.
In order to achieve a better outcome for pancreatic cancer patients, reliable biomarkers are required which allow improved diagnosis. These may emanate from more detailed molecular understanding of the aggressive nature this disease. Having previously reported that Notch3 activation appeared be associated with disease, we have now examined components pathway (Notch1, Notch3, Notch4, HES-1, HEY-1) in detail resectable (n = 42) and non-resectable 50) tumours compared uninvolved pancreas. All...
Solution-grown single crystals of furan/phenylene co-oligomer combine efficient charge transport properties and high fluorescence efficiency.
Microplastics (MPs) in aquatic environments can be associated with various substances, including persistent organic pollutants, which add to the problem of plastic ecotoxicity. The abundance 1-5 mm microplastics and concentrations particle-adsorbed organochlorine pesticides (OCPs) polychlorinated biphenyls (PCBs) sandy sediments from three beaches recreational areas along upper Ob River Western Siberia were assessed. MP pollution levels beach sands ranged 24 ± 20.7 104 46.2 items m
Electrospinning is a perspective method widely suggested for use in bioengineering applications, but the variability currently available data and equipment necessitates additional research to ascertain desirable methodology. In this study, we aimed describe effects of electrospinning technique alterations on structural mechanical properties (1,7)-polyoxepan-2-one (poly-ε-caprolactone, PCL) scaffolds, such as circumferential longitudinal stress/strain curves, comparison with corresponding...
// Anna S Tsimokha 1 , Valentina A. Kulichkova Elena V. Karpova 2 Julia J. Zaykova Nikolai D Aksenov Anastasia Vasilishina Andrei Kropotov Alexey Antonov 3,4 and Barlev 1,2,4 Institute of Cytology, Russian Academy Sciences, 194064 St. Petersburg, Russia Department Biochemistry, University Leicester, LE1 9HN 3 MRC Toxicology Unit, 4 Molecular Pharmacology laboratory, Saint-Petersburg Technology, 190013, Correspondence: Barlev, email: Keywords : 26S proteasome, miRNA, DNA damage, doxorubicin...
The causes of heart valve bioprosthetic calcification are still not clear. In this paper, we compared the in porcine aorta (Ao) and bovine jugular vein (Ve) walls, as well pericardium (Pe). Biomaterials were crosslinked with glutaraldehyde (GA) diepoxide (DE), after which they implanted subcutaneously young rats for 10, 20, 30 days. Collagen, elastin, fibrillin visualized non-implanted samples. Atomic absorption spectroscopy, histological methods, scanning electron microscopy,...
Abstract The reactions of (+)‐car‐2‐ene ( 1 ) and (+)‐car‐3‐ene 2 with aldehydes in the presence montmorillonite clay were studied for first time Schemes 3 5 ). major products these are optically active, substituted hexahydroisobenzofurans, probably formed as a result an attack protonated aldehyde at cyclopropane ring. Quite unexpectedly, cis ‐configured ring‐fusion site; fact was established by means quantum‐chemical calculations NMR data. It appeared that behavior : mixture / K10 differed...
An effective protocol for the solvent‐free fluorination of electron‐rich aromatic compounds with 1‐chloromethyl‐4‐fluoro‐1,4‐diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (F‐TEDA‐BF 4 ) is described. The allows easy and efficient isolation fluorinated products in high yields purities low E factors (kg waste kg product –1 by vacuum‐sublimation without use any solvent. solid‐state naphthalen‐2‐ol was studied differential thermal analysis, scanning electron microscopy used to obtain...
Carbon nanotubes (CNTs) are used in applications ranging from electrical engineering to medical device manufacturing. It is well known that the addition of can influence mechanical properties various industrial materials, including plastics. Electrospinning a popular method for fabricating nanomaterials, widely suggested polymer scaffold In this study, we aimed describe single-walled carbon nanotube (SWCNT) suspensions on polymeric poured films and electrospun scaffolds investigate their...