A5005777174- Antibiotics Pharmacokinetics and Efficacy
- Colorectal Cancer Treatments and Studies
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Antifungal resistance and susceptibility
- Neuropeptides and Animal Physiology
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Drug Transport and Resistance Mechanisms
- Blood disorders and treatments
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- Hormonal Regulation and Hypertension
- Pharmacy and Medical Practices
- Potassium and Related Disorders
- Lung Cancer Treatments and Mutations
- Pharmacogenetics and Drug Metabolism
- Salivary Gland Disorders and Functions
- Pancreatic and Hepatic Oncology Research
- Stress Responses and Cortisol
- Cancer Immunotherapy and Biomarkers
- Biosimilars and Bioanalytical Methods
- Cancer, Stress, Anesthesia, and Immune Response
- Parathyroid Disorders and Treatments
- Metabolism and Genetic Disorders
Oita University Hospital
2013-2025
Shujitsu University
2024
Okayama University
2024
Oita University
2012-2020
Imbalance between gastrointestinal peptides has been implicated as a cause of chemotherapy-induced nausea and vomiting (CINV) anorexia in cancer patients. This study comprehensively evaluated the changes blood levels five peptide: substance P, neuropeptide (NPY), motilin, ghrelin leptin, following chemotherapy, relationship these CINV or anorexia. single-center, prospective, observational recruited 20 patients with esophageal cancer, urothelial testiculoma undergoing cisplatin-based...
Genetic factors, inflammatory cytokines such as interleukin (IL)‐6 and tumor necrosis factor‐α (TNF‐α), uremic substances 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid (CMPF) have been reported to affect organic anion transporting polypeptide (OATP)1B1 transport activity. However, the relationship between OATP1B1 activity these factors in patients with cancer cachexia has not reported. This study aimed identify contributing individual differences cachexia, using coproporphyrin‐I (CP‐I)...
Augmented renal clearance (ARC) and febrile neutropenia (FN) increase drug primarily through glomerular filtration. In this study, we evaluated the influence of ARC FN on dose-normalized trough concentration (C/D) and/or teicoplanin (TEIC) by comparing C/D between patients with non-ARC, non-FN. This retrospective, single-center, observational cohort study enrolled 309 who received intravenous injections TEIC July 2016 September 2021. Of 94 met selection criteria, 25 satisfied definition, 31...
Abstract Organic anion‐transporting polypeptides (OATP)1B are drug transporters mainly expressed in the sinusoidal membrane. Many studies have suggested that OATP1B activity is affected by genetic factor, uremic toxin 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid (CMPF), and inflammatory cytokines, such as tumor necrosis factor‐α (TNF‐α) interleukin‐6 (IL‐6). Coproporphyrin‐I (CP‐I) spotlighted a highly accurate endogenous substrate of OATP1B. We previously reported positive correlation...
Abstract Plasma 4β‐hydroxycholesterol (OHC) has drawn attention as an endogenous substrate indicating CYP3A activity. 4β‐OHC is produced by hydroxylation CYP3A4 and CYP3A5 cholesterol autoxidation. 4α‐OHC autoxidation not affected This study aimed to evaluate the usefulness of plasma concentration minus (4β‐OHC–4α‐OHC) compared with 4β‐OHC/total (TC) ratio in cross‐sectional evaluation Four hundred sixteen general adults were divided into 191 CYP3A5*1 carriers 225 non‐carriers. Twenty‐six...
With cancer diagnosis occurring at older ages, the use of immune checkpoint inhibitors (ICIs) has extended to adults. However, safety immune-related adverse events (irAEs) in this population remains unclear and relies on data extrapolated from younger This multicenter retrospective study aimed examine irAE prevalence tolerability We included 436 patients with non-small lung undergoing ICI therapy dichotomized them into two age groups (< or ≥75 years). Incidence any grade, grade ≥3 irAEs,...
Organic anion transporting polypeptides (OATPs) 1B are drug transporters mainly expressed in the sinusoidal membrane. In previous reports, genetic factor, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), which is one of uremic toxins, inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) decreased OATP1B1 activity vitro, but vivo effects these factors have not been elucidated. Plasma coproporphyrin-I (CP-I) spotlighted a highly accurate endogenous...
Organic anion transporting polypeptides (OATP) 1B1 and 1B3 are expressed in liver cells involved drug uptake the liver. OATP1B activity varies due to polymorphisms is decreased by inhibitors. Variability of impacts pharmacokinetics substrate drugs through drug–drug interactions. Lately, coproporphyrin-I (CP-I) -III (CP-III) have been featured as quantitative endogenous biomarkers for evaluating OATP1B. CP-III has reported be transported not only but also OATP2B1 vitro. We established a...
What is known and objective Thrombocytopenia one of the typical adverse events caused by linezolid (LZD). Recently, some cases severe hyponatraemia occurring while receiving LZD have been reported. This study investigated a possible relationship between LZD-induced thrombocytopenia identified risk factors for and/or thrombocytopenia. Methods In this retrospective, single-centre, observational cohort study, 63 hospitalized patients aged over 18 years who received intravenous injection more...
Background: Lenvatinib is increasingly being selected as the first-line treatment for unresectable hepatocellular carcinoma (HCC) based on results of REFLECT trial. However, early discontinuation lenvatinib because adverse effects a frequent occurrence. Hence, difficult drug use in clinical setting. One causes that dose mainly determined by body weight alone, despite high interindividual variability. To overcome this problem, dosing regimen population pharmacokinetic (PPK) model HCC patients...
Because tacrolimus is predominantly metabolized by CYP3A, the blood concentration/dose (C/D) ratio affected CYP3A5 polymorphism. Parathyroid hormone (PTH) expression increases in secondary hyperparathyroidism, which frequently associated with end-stage renal disease. Recently, PTH has been shown to downregulate CYP3A at mRNA level. In this study, we examined influence of polymorphism on and association serum intact-PTH (iPTH) level concentration patients disease just before kidney...
Several cases of severe hyponatremia induced by linezolid (LZD) were reported. However, infections could also cause increasing vasopressin secretion. To prove that is associated with LZD rather than infection, we compared the incidence and risk developing between patients receiving those vancomycin (VCM). A retrospective, single-center, observational cohort study was conducted in aged 18 years or older who received intravenous VCM for 7 d longer. Hyponatremia defined as serum sodium level...
Pilocarpine, a muscarinic receptor agonist, has been used for the treatment of dry mouth. Salivary glands are supplied with nerve fibres that contain neuropeptides, such as substance P, calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP), which important modulators salivation. It is known measurement salivary plasma levels neuropeptides useful assessing dose-pharmacological effect relationship drugs. The between action pilocarpine in humans not studied....
The pharmacokinetics of voriconazole shows large intra-individual and inter-individual variability is affected by various factors. Recently, inflammation has been focused as a significant factor affecting the variability. This study aimed to compare influence C-reactive protein (CRP) other clinical laboratory parameters on in trough concentration examine impact patients with hematological malignancies. We conducted retrospective, single-center, observational cohort study. Forty-two...
Abstract Because either trough or peak concentration at 2 h after administration is measured in routine therapeutic drug monitoring for cyclosporine A (CyA), a quantification method with wide‐range calibration curve capable of simultaneously measuring both concentrations required. We developed sensitive, and high‐throughput CyA whole blood using ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS), compared patients’ levels by UPLC–MS/MS antibody‐conjugated magnetic...
For intensive care unit (ICU) patients, injectable voriconazole (VRCZ) is difficult to use because the patients often develop acute kidney injury. Since many ICU have consciousness disturbance, oral ingestion of tablet formulation also difficult, and administration a suspension via enteral feeding tube required when using VRCZ. In this study, we investigated in vitro adsorption property VRCZ performed pharmacokinetic analysis prepared by powdering simple for patients. was tube-administered...
Background: Febrile neutropenia promotes renal drug excretion. Adult and pediatric patients with febrile exhibit a lower vancomycin concentration/dose (relative to bodyweight) ratio than those other infections. In patients, function relative bodyweight varies depending on age, clearance is age dependent. This study aimed analyze the effects of pharmacokinetics in age-stratified patients. Methods: retrospective, single-center, observational cohort analyzed 112 hospitalized who met selection...
Abstract Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total when was discontinued due to adverse effects. Elevated free concentration may have a causal relationship with the development of