A5037889780- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nosocomial Infections in ICU
- Pneumocystis jirovecii pneumonia detection and treatment
- Tuberculosis Research and Epidemiology
- Antifungal resistance and susceptibility
- Dysphagia Assessment and Management
- Sarcoidosis and Beryllium Toxicity Research
- Fungal Infections and Studies
- Infectious Diseases and Tuberculosis
- Occupational exposure and asthma
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Infectious Diseases and Mycology
- Eosinophilic Disorders and Syndromes
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Asthma and respiratory diseases
- Emergency and Acute Care Studies
- Occupational and environmental lung diseases
- Central Venous Catheters and Hemodialysis
- Antibiotic Use and Resistance
- Esophageal and GI Pathology
- Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
Tenshi Hospital
2011-2025
Oita University
2013-2022
Oita University Hospital
2008-2015
Nagasaki Medical Center
2011
Aspiration pneumonia is one of the common presentations community-acquired (CAP) and healthcare-associated (HCAP). However, its significance has not yet been fully evaluated due to difficulties associated with diagnosis this condition. This study aimed evaluate impact objectively defined aspiration on patients' prognosis CAP HCAP.This a multicenter retrospective cohort consisting 417 220 HCAP patients. We as having both risk factors for (dysphagia neurological disorder, or disturbance...
Aim: No large case series has so far shown the chest computed tomography (CT) features in patients with aspiration pneumonia, despite fact that pneumonia is most common pulmonary disease elderly and regarded as gravity‐dependent pneumonia. The aim of present study was to elucidate CT based on patients' status dysphagia‐associated Methods: A total 53 patients, who were hospitalized because subsequently confirmed have dysphagia by videofluorography, entered into this study. findings...
Statins are 3-hydroxy-3-methylglutaryl-co-enzyme A reductase inhibitors of cholesterol biosynthesis, and have been reported to exert pleiotropic effects on cellular signalling functions involved in inflammation. Recent reports demonstrated that previous statin therapy reduced the risk pneumonia or increased survival patients with community-acquired pneumonia. However, precise mechanisms responsible for these unclear. In present study, we examined statins cytokine production from...
ABSTRACT Background and objective: More than 100 000 Japanese die of pneumonia every year. The number people residing in nursing homes is increasing with the ageing population. In 2005, American Thoracic Society/Infectious Diseases Society America (ATS/IDSA) published important guidelines for management healthcare‐associated (HCAP). Japan, however, optimum strategy HCAP still unclear. purpose this study was to clarify clinical features patients HCAP. Methods: Patients ( n = 202) who were...
Erector spinae muscle (ESM) size has been reported as a predictor of prognosis in patients with some respiratory diseases. This study aimed to assess the association ESM on all-cause in-hospital mortality among elderly pneumonia. We retrospectively included (age: ≥ 65 years) admitted hospital from January 2015 December 2017 for community-acquired pneumonia who underwent chest computed tomography (CT) admission. The cross-sectional area (ESMcsa) was measured single-slice CT image at end 12th...
Community-acquired pneumonia is a common disease with considerable morbidity and mortality, for which Streptococcus pneumoniae accepted as leading cause. Although β-lactam-plus-macrolide combination therapy this recommended in several guidelines, the clinical efficacy of strategy against pneumococcal remains controversial. In study, we examined effects on lethal mouse explored mechanisms action vitro vivo We investigated survival, lung bacterial burden, cellular host responses...
It remains unclear if antibiotics should be used for the treatment of acute aspiration bronchitis to prevent development pneumonia. This study aimed assess associations between use and pneumonia among patients with bronchitis.
To the Editor,A recent review in present journal summarized knowledge on virulence of Stenotrophomonas maltophilia [1]. The capability agent to act as an opportunistic pa...
A 35-year-old man developed invasive pulmonary aspergillosis (IPA) with severe neutropenia after umbilical cord stem cell transplantation for chronic myelogeneous leukemia. Filamentous fungus isolated from his sputum was identified as Aspergillus terreus. Despite systemic amphotericin B (AMPH) administration, IPA progressed. However, intravenous administration of micafungin (MCFG) and oral itraconazole improved clinical data symptoms, although he later died massive hemoptysis. Examination...
Periostin was investigated as a biomarker for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). This prospective study measured serum monomeric and total periostin, Klebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), lactate dehydrogenase (LDH) in 19 patients with RA-ILD, 20 RA without ILD, 137 healthy controls (HC). All biomarkers were higher RA-ILD than HC or ILD. KL-6 accurately detected ILD (area under curve [AUC] = 0.939) moderately SP-D periostin (AUC 0.803,...
This study investigated the utility of periostin, a matricellular protein, as prognostic biomarker in patients with idiopathic pulmonary fibrosis (IPF) who received nintedanib. Monomeric and total periostin levels were measured by enzyme-linked immunosorbent assay 87 eligible participated multicenter prospective study. Forty-three antifibrotic drug-naive IPF described previous studies set historical controls. not significantly associated change forced vital capacity (FVC) or diffusing lungs...
Abstract Although lung involvement in aspiration pneumonia typically has a gravity-dependent distribution on chest images, which patient’s conditions contribute to its radiological pattern not been fully elucidated. This study was designed determine the factors associated with of community-acquired (CAP) computed tomography (CT). retrospective included elderly patients aged ≥ 65 years CAP who underwent CT within 1 week before or after admission. The lower lobe- and posterior-predominant...