A5043421510- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- interferon and immune responses
- RNA Research and Splicing
- RNA regulation and disease
- Viral gastroenteritis research and epidemiology
- RNA and protein synthesis mechanisms
- Infectious Encephalopathies and Encephalitis
- SARS-CoV-2 detection and testing
- Genetics and Neurodevelopmental Disorders
- Neurogenetic and Muscular Disorders Research
- Protein Structure and Dynamics
- Animal Virus Infections Studies
- Energetic Materials and Combustion
- thermodynamics and calorimetric analyses
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
Duquesne University
2018-2022
National Institute of Standards
2022
National Institute of Standards and Technology
2022
Fused in sarcoma (FUS), identified as the heterogeneous nuclear ribonuclear protein P2, is expressed neuronal and non-neuronal tissue, among other functions, has been implicated messenger RNA (mRNA) transport possibly local translation regulation. Although FUS mainly localized to nucleus, neurons also shown localize post-synaptic density, well pre-synapse. Additionally, deletion cultured hippocampal cells results abnormal spine dendrite morphology. Thus, may play a role synaptic function...
Abstract The ongoing COVID-19 pandemic highlights the necessity for a more fundamental understanding of coronavirus life cycle. causative agent disease, SARS-CoV-2, is being studied extensively from structural standpoint in order to gain insight into key molecular mechanisms required its survival. Contained within untranslated regions SARS-CoV-2 genome are various conserved stem-loop elements that believed function RNA replication, viral protein translation, and discontinuous transcription....
Alzheimer's disease (AD), the most common age-related neurodegenerative disease, is associated with various forms of cognitive and functional impairment that worsen progression. AD typically characterized as a protein misfolding in which abnormal plaques form due to accumulation tau β-amyloid (Aβ) proteins. An assortment proteins responsible for processing trafficking Aβ, including sortilin-related receptor 1 (SORL1). Recently, genome-wide association study microRNA-related variants found...
The functional role of the highly conserved stem-loop II motif (s2m) in SARS-CoV and SARS-CoV-2 viral lifecycle remains enigmatic an intense area research. Structure dynamics s2m are key to establishing a structure–function connection, yet full set atomistic resolution coordinates is not available for s2m. Our work constructs three-dimensional consistent with NMR solution phase data provides comparative analysis its counterpart We employed initial based on PDB ID 1XJR two models s2m: one...
The functional role of the highly conserved stem-loop II motif (s2m) in SARS-CoV and SARS-CoV-2 viral lifecycle remains enigmatic an intense area research. Structure dynamics s2m are key to establishing a structure-function connection, yet full set atomistic resolution coordinates is not available for s2m. Our work constructs three-dimensional consistent with NMR solution phase data provides comparative analysis its counterpart We employed initial based on PDB ID: 1XJR two models s2m: one...
ABSTRACT The ongoing COVID-19 pandemic highlights the necessity for a more fundamental understanding of coronavirus life cycle. causative agent disease, SARS-CoV-2, is being studied extensively from structural standpoint in order to gain insight into key molecular mechanisms required its survival. Contained within untranslated regions SARS-CoV-2 genome are various conserved stem-loop elements that believed function RNA replication, viral protein translation, and discontinuous transcription....
The functional role of the highly conserved stem-loop II motif (s2m) in SARS-CoV and SARS-CoV-2 viral lifecycle remains enigmatic an intense area research. Structure dynamics s2m are key to establishing a structure-function connection, yet full set atomistic resolution coordinates is not available for s2m. Our work constructs three-dimensional consistent with NMR solution phase data provides comparative analysis its counterpart We employed initial based on PDB ID: 1XJR two models s2m: one...