A5101937054- Cystic Fibrosis Research Advances
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Global Security and Public Health
- Obesity, Physical Activity, Diet
- Bacillus and Francisella bacterial research
- Radiopharmaceutical Chemistry and Applications
- Respiratory Support and Mechanisms
- Bladder and Urothelial Cancer Treatments
- Neonatal Respiratory Health Research
- Terrorism, Counterterrorism, and Political Violence
- Hemoglobin structure and function
- Cardiac, Anesthesia and Surgical Outcomes
- Appendicitis Diagnosis and Management
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- Cardiovascular and exercise physiology
- Cancer, Lipids, and Metabolism
- Hip and Femur Fractures
- Telemedicine and Telehealth Implementation
- Colorectal Cancer Surgical Treatments
- Mobile Health and mHealth Applications
- Yersinia bacterium, plague, ectoparasites research
Blue Earth Diagnostics (United Kingdom)
2017-2025
Dalhousie University
2013-2024
Servier (United Kingdom)
2020
Izaak Walton Killam Health Centre
2020
Saint Louis University
2020
St. Michael's Hospital
2011-2018
University of Wisconsin–Madison
2012-2018
University of Bristol
2014-2017
University of Oxford
2013-2016
John Radcliffe Hospital
2015-2016
The relationships of lung functions to maximal respiratory pressure relative the role other recognized determinants (height, weight, age, and smoking status) were examined in 924 healthy Caucasian urban residents, 369 males 15 35 yr age 555 females 13 age. In subjects no longer thought be growing stature, height was main determinant most functions. After height, pressures forced vital capacity (FVC), expiratory volume one second (FEV), peak flow men women, with weight also an important...
No AccessJournal of UrologyAdult Urology1 Feb 2019The Impact Positron Emission Tomography with 18F-Fluciclovine on the Treatment Biochemical Recurrence Prostate Cancer: Results from LOCATE Trial Gerald L. Andriole, Lale Kostakoglu, Albert Chau, Fenghai Duan, Umar Mahmood, David A. Mankoff, M. Schuster, and Barry Siegel AndrioleGerald Andriole *Correspondence: Division Urologic Surgery, Department Surgery Alvin J. Siteman Cancer Center, Washington University School Medicine, 4921 Parkview...
177Lu-rhPSMA-10.1 is a novel radiohybrid prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy for prostate cancer. We conducted preclinical analyses on non-tumor-bearing BALB/c mice and cancer human xenograft mouse models (LNCAP 22Rv1 xenografts) to evaluate its biodistribution therapeutic efficacy. Methods: Longitudinal of was evaluated in xenografts. Tissues interest were harvested, radioactivity measured 1-168 h after injection 1 MBq (4 per time point). compared...
Focal therapy is being offered as a viable alternative for men with localised prostate cancer (PCa), but it unclear which may be suitable.To determine the proportion of PCa who are potentially suitable focal therapy.Our institutional transperineal template prostate-mapping (TTPM) biopsy registry 377 from 2006 to 2010 identified 291 consecutive no prior treatment.TTPM biopsies using 5-mm sampling frame.Suitability required (1) unifocal, (2) unilateral, (3) bilateral/bifocal at least one...
The marmoset, Saguinus mystax, developed signs of disease similar to human hepatitis when inoculated with marmoset sera containing Deinhardt's agent, or from patients infectious but not serum hepatitis-associated antigen partially purified antigen. evidence were 3- 10-fold increase above normal SGPT levels and histologic changes single liver cell necroses periportal lymphocytic infiltration. Hepatitis-associated was found in any by complement-fixation tests electron microscopy.
Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in human skeletal muscle cells. Variations of CFTR dysfunction among patients with cystic may be an important determinant maximal exercise capacity fibrosis. Previous studies on the relationship between genotype and are scarce contradictory.This study was designed to explore factors influencing capacity, as peak oxygen uptake (V.O2peak), a specific focus children adults fibrosis.In international, multicenter,...
Summary Inhalational anthrax is a rare but potentially fatal infection in man. The common marmoset ( Callithrix jacchus ) was evaluated as small non‐human primate (NHP) model of inhalational infection, an alternative to larger NHP species. found be susceptible exposure Bacillus anthracis Ames strain. pathophysiology following similar that previously reported the rhesus and cynomolgus macaque humans. calculated LD 50 for B. strain 1.47 × 10 3 colony‐forming units, compared with published 5.5...
Physical activity and exercise training play an important role in the clinical management of patients with cystic fibrosis (CF). Exercise is more common recognized as essential part rehabilitation programmes overall CF care. Regular associated improved aerobic anaerobic capacity, higher pulmonary function, enhanced airway mucus clearance. Furthermore, fitness have survival. Aerobic may different effects, while combination both been reported to be beneficial CF. However, remains underutilised...
Despite the acceptance of physical activity (PA) being integral to a young person's health, children with disability often exhibit low levels PA. In people cystic fibrosis (CF) importance exercise and daily PA is acknowledged by clinicians their support teams, however, there lack knowledge related its prescription. CF recessive genetic disorder affecting lung, pancreas sweat glands. most common life shortening disease in Caucasian population for which no cure. UK, affects over 9000 people,...
ABSTRACT During urinary tract infections (UTIs), uropathogenic Escherichia coli must maintain a delicate balance between sessility and motility to achieve successful infection of both the bladder kidneys. Previous studies showed that cyclic dimeric GMP (c-di-GMP) levels aid in control transition motile nonmotile states E. . The yfiRNB locus CFT073 contains genes for YfiN, diguanylate cyclase, its activity regulators, YfiR YfiB. Deletion yfiR yielded mutant was attenuated kidneys when tested...
Summary Susceptibility and lethality studies of inhalational tularaemia were undertaken using the common marmoset ( Callithrix jacchus ) to determine its suitability as a non‐human primate model. Pairs marmosets exposed varying challenge doses Francisella tularensis by airborne route monitored for up 14 days postchallenge (p.c.). Lethal infection was achieved following retained dose less than 10 bacterial colony‐forming units (CFU). However, precise LD 50 determination not possible. The...
Cystathionine β-synthase (CBS) is an essential pyridoxal 5'-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor unknown function. Herein we describe enzymatic and spectroscopic properties disease-associated R266K hCBS variant, which has altered hydrogen-bonding environment. The low-spin, six-coordinate Fe(III) bearing His/Cys ligation motif, like WT hCBS;...
Abstract Background Physical activity participation among preschoolers in childcare settings are low, and interventions to increase physical levels have produced mixed results. The Literacy the Early Years (PLEY) project implemented a six-month childcare-based outdoor loose parts play intervention centres Nova Scotia, Canada. purpose of this study was examine impact PLEY on development domains literacy (physical activity, competence, confidence motivation, knowledge understanding) attending...
Development of fundamental movement skills in early childhood supports lifelong health. The potential for outdoor play with loose parts to enhance has not been investigated. A multi-methods randomized controlled design was used determine the efficacy integrating into Nova Scotia childcare centers (19 sites: 11 interventions, 8 control). Movement (n = 209, age 3-5 years) were assessed over a 6-month period investigate changes time and between groups. Qualitative data also collected on...
Rationale: Cardiopulmonary exercise testing (CPET) provides prognostic information in cystic fibrosis (CF); however, its value for patients with advanced CF lung disease (ACFLD) is unknown.Objectives: To determine the of CPET on risk death or transplant (LTX) within 2-years. Methods:We retrospectively collected data from 20 centers Asia, Australia, Europe, and North America a forced expiratory volume 1s (FEV 1 ) 40% predicted who performed cycle ergometer between January 2008 December...