A5010151535- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Long-Term Effects of COVID-19
- Eosinophilic Disorders and Syndromes
- Obstructive Sleep Apnea Research
- Neonatal Respiratory Health Research
- COVID-19 Clinical Research Studies
- Cystic Fibrosis Research Advances
- Nitric Oxide and Endothelin Effects
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Advanced Chemical Sensor Technologies
- Medical Imaging and Pathology Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular and Diving-Related Complications
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Olfactory and Sensory Function Studies
- Non-Invasive Vital Sign Monitoring
- Voice and Speech Disorders
Université Paris Cité
2014-2024
Assistance Publique – Hôpitaux de Paris
2013-2024
Hôpital Cochin
2014-2024
Hôpital Européen Georges-Pompidou
2022-2024
Délégation Paris 5
2010-2018
Sorbonne Paris Cité
2014-2018
Hôpital Broca
2018
Institut Cochin
2018
Inserm
2018
Hôpital Pasteur
2017
Elevated serum CC chemokine ligand (CCL)18 reflects lung fibrosis activity in systemic sclerosis (SSc) and could be an early marker of function worsening. Therefore, we sought to evaluate whether CCL18 levels at baseline predict worsening disease SSc. In this prospective study, 83 SSc patients were analysed longitudinally over a 4-yr observation period for the risk occurrence combined deleterious events, defined as 10% decrease from total capacity or forced vital % predicted, death,...
Purpose To develop a deep learning algorithm for the automatic assessment of extent systemic sclerosis (SSc)–related interstitial lung disease (ILD) on chest CT images. Materials and Methods This retrospective study included 208 patients with SSc (median age, 57 years; 167 women) evaluated between January 2009 October 2017. A multicomponent neural network (AtlasNet) was trained 6888 fully annotated images (80% training 20% validation) from 17 no, mild, or severe disease. The model tested...
<h3>Background</h3> Respiratory failure is a life-threatening and unpredictable complication of systemic sclerosis (SSc). A study was undertaken to assess the value alveolar nitric oxide (NO) in predicting risk lung function deterioration leading respiratory or death patients with SSc. <h3>Methods</h3> 105 SSc were enrolled this prospective cohort followed longitudinally over 3-year period during which occurrence deleterious events analysed according concentration (C<sub>A</sub>no),...
Abstract Objective Systemic sclerosis (SSc) is characterized by microvascular damage, fibrosis of skin and visceral organs, autoimmunity. Previous studies have shown that angiotensin II involved in the synthesis type I collagen. We investigated whether blockade receptor (AT 1 ) irbesartan reduces lung 2 murine models SSc. Methods SSc was induced daily intradermal injection HOCl into backs BALB/c mice (HOCl‐induced SSc). Mice were treated with oral gavage. Results Irbesartan reduced dermal...
Background: Systemic sclerosis (SSc) is a connective-tissue disease characterized by vascular injury, immune-system disorders, and excessive fibrosis of the skin multiple internal organs. Recent reports found that RhoA/Rho-kinase (ROCK) pathway implicated in various fibrogenic diseases. Intradermal injection hypochlorous acid (HOCl)-generating solution induced inflammation, autoimmune activation, fibrosis, mimicking cutaneous diffuse form SSc humans. Our study aimed firstly to describe...
Background: The measure of fractional exhaled nitric oxide (FENO) in the airways is a useful tool to guide diagnosis and titration inhaled corticosteroids patients with asthma. However, its role allergic rhinitis (AR), especially subjects asthma, not well established. Objective: To study cutoff nasal FENO AR AR-asthma compared age-matched without or asthma correlations clinical functional characteristics. Methods: was cross sectional descriptive. Subjects were grouped into control subjects,...
Background and Objective . The concentration of exhaled nitric oxide (eNO), reflecting the activity inducible NO synthase in airway epithelium, has been found to increase patients with obstructive sleep apnea (OSA). This study aimed measure eNO suspected OSA correlate different parameters clinical characteristics. Methods In this cross-sectional study, all underwent in-lab overnight polysomnography (PSG) measurement using a method multiple flow rates before after PSG (pre- post-PSG). Results...
Background: Pulmonary hypertension (PH) is a common complication of idiopathic pulmonary fibrosis (IPF) that significantly contributes to morbidity and mortality. Macrophage migration inhibitory factor (MIF) critical in vascular remodeling the circulation. Objectives: We tested effects two small molecules targeting MIF on bleomycin (BLM)-induced collagen deposition, PH, mouse lungs. Methods: examined distribution pattern MIF, CD74, CXCR4 lungs patients with IPF-PH BLM-injected mice. Then,...
Endothelial dysfunction is one of the main consequences toxic effects cigarette smoke on vascular system. Increasing evidence suggests that small G-protein RhoA and its downstream effectors, Rho-kinases (ROCKs), are involved in systemic endothelial induced by smoke. This study aimed to evaluate role RhoA/ROCKs pathway pulmonary artery function current smokers with normal lung function. Lung tissues were obtained from nonsmokers who underwent lobectomy for carcinoma. Arterial relaxation...
Recent evidence suggests that activation of RhoA/Rho-kinase accounts for systemic and pulmonary endothelial dysfunction in smokers with normal lung function. However, its role patients chronic obstructive disease (COPD) has not yet been investigated. The aim this study was to evaluate the regulation pathway COPD. Pulmonary arteries were obtained from nonsmokers (control subjects) nonhypoxemic hypoxemic COPD (n = 6-7/group). Endothelium-dependent -independent relaxations evaluated by...
The lung just like all other organs is affected by age. matures the age of 20 and age-related changes start around middle age, at 40-50 years. Exhaled nitric oxide (FENO) has been shown to be height gender dependent. We hypothesize that (NO) parameters alveolar NO (CANO), airway flux (JawNO), diffusing capacity (DawNO) wall content (CawNO) will also demonstrate this dependence. Data from healthy subjects were gathered current authors their earlier publications in which individuals included...
ABSTRACT Aeromonas popoffii is a recently described species isolated mainly from freshwater. An isolate of was found to be responsible for urinary tract infection in 13-year-old boy suffering spina bifida with enterocystoplasty. This the first reported case human attributed this species.
The present study aimed to develop an automated computed tomography (CT) score based on the CT quantification of high-attenuating lung structures, in order provide a quantitative assessment structural abnormalities patients with Primary Ciliary Dyskinesia (PCD). Adult (≥18 years) PCD who underwent both chest and spirometry within 6-month period were retrospectively included. Commercially available segmentation software was used isolate lungs from mediastinum wall obtain histograms density....
Pulmonary sequelae as assessed by pulmonary function tests (PFTs) are often reported in patients infected SARS-CoV-2 during the post-COVID-19 period. Little is known, however, about status of inflammation clinical recovery after patients' discharge from hospitals. We prospectively measured PFTs coupled with exhaled nitric oxide (NO) stemming proximal airways (FeNO) and distal lung (CaNO) 169 consecutive varying degrees severity COVID-19 six weeks to one year acute infection SARS-CoV-2. The...
Rationale: Cardiopulmonary exercise testing (CPET) provides prognostic information in cystic fibrosis (CF); however, its value for patients with advanced CF lung disease (ACFLD) is unknown.Objectives: To determine the of CPET on risk death or transplant (LTX) within 2-years. Methods:We retrospectively collected data from 20 centers Asia, Australia, Europe, and North America a forced expiratory volume 1s (FEV 1 ) 40% predicted who performed cycle ergometer between January 2008 December...
Objective. Lung inflammation is present in patients with systemic sclerosis (SSc) and interstitial lung disease (ILD), but the mechanisms linking inflammatory fibrotic processes ILD are unknown. Our aim was to investigate whether alveolar inflammation, reflected by increased concentration of exhaled nitric oxide (C A NO), related ability serum from SSc induce pulmonary fibroblast proliferation (PFP) myofibroblast conversion. Methods. C NO measured all subjects (37 10 healthy controls) whose...
Exhaled nitric oxide (NO) is increased as a result of lung inflammation, which in turn causes subsequent interstitial disease patients with systemic sclerosis (SSc). However, the exact time course inflammatory and fibrotic changes SSc has not yet been described.