A5023055800- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Microscopic Colitis
- Colorectal Cancer Treatments and Studies
Digital Proteomics (United States)
2017
Colorectal cancer (CRC) testing programs reduce mortality; however, approximately 40% of the recommended population who should undergo CRC does not. Early colon detection in patient populations ineligible for testing, such as elderly or those with significant comorbidities, could have clinical benefit. Despite many attempts to identify individual protein markers this disease, little progress has been made. Targeted mass spectrometry, using multiple reaction monitoring (MRM) technology,...
The aim was to improve upon an existing blood-based colorectal cancer (CRC) test directed high-risk symptomatic patients, by developing a new CRC classifier be used with embodiment. uses robust assay format—electrochemiluminescence immunoassays—to quantify protein concentrations. achieved building and validating using concentration measures from large sample set representing true intent-to-test (ITT) population. 4435 patient samples were drawn the Endoscopy II set. Samples collected at seven...