A5053868703- Electrochemical Analysis and Applications
- Beetle Biology and Toxicology Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Biochemical and Molecular Research
- Metabolomics and Mass Spectrometry Studies
- Spectroscopy and Quantum Chemical Studies
- Ginseng Biological Effects and Applications
- Advanced Synthetic Organic Chemistry
- Lipid Membrane Structure and Behavior
- Quantum Dots Synthesis And Properties
- Synthesis and bioactivity of alkaloids
- Insect Resistance and Genetics
- Pharmacogenetics and Drug Metabolism
- TiO2 Photocatalysis and Solar Cells
- Natural Compounds in Disease Treatment
- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Advanced Biosensing Techniques and Applications
- Plant and Biological Electrophysiology Studies
- Sepsis Diagnosis and Treatment
- Biological and pharmacological studies of plants
- Plant biochemistry and biosynthesis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Zunyi Medical University
2021-2024
Jilin University
2016-2019
State Key Laboratory of Supramolecular Structure and Materials
2016-2019
Jilin Medical University
2016
Yanshan University
2013-2014
Johnson Foundation
1975
University of Pennsylvania
1975
α-Fetoprotein (AFP) is an important tumor biomarker. In particular, the overexpression of AFP-L3 associated with hepatocellular carcinoma (HCC). Accordingly, several hospitals have begun to employ ratio total AFP level (AFP-L3%) as new diagnostic evidence for HCC owing its high accuracy. However, current methods detection and are time-consuming, require multiple samples, lack in sensitivity specificity. Herein, we present a novel concept early diagnosis based on combination Raman frequency...
The interfaces of metal–dye molecule–semiconductor sandwich structure are very important in the investigation dye-sensitized solar cells (DSSCs) where metals used to enhance absorption. In this work, we first designed and synthesized Ag/N719 Ag/N719/TiO2 systems investigate chemical binding type at Ag/N719/TiO2. results Raman spectra under laser excitations 532, 633, 785 nm clarified that SCN groups adsorbed on Ag surface via S terminal TiO2 layer possibly bound ester linkage (—O—C═O) COOH...
This study compared the effects of hydroxyethyl starch 130/0.4, 200/0.5, and succinylated gelatin on oxidative stress inflammatory response in a rodent hemorrhagic shock model.Sodium pentobarbital-anesthetized adult male Wistar rats (200 g to 220 g) were subjected severe volume-controlled hemorrhage using arterial blood withdrawal (30 mL/kg 33 mL/kg) resuscitated with colloid solution at same volume as (hydroxyethyl or gelatin). Arterial gas parameters monitored. Malondialdehyde (MDA)...
Abstract The interaction of cytochrome c (Cyt c) with cardiolipin (CL) is believed to play an important role in the initial events apoptosis. Herein, we investigate structural changes CL‐bound Fe 2+ Cyt and correlation release through surface‐enhanced Raman spectroscopy (SERS) on nickel substrates. SERS results together molecular dynamics simulation reveal that undergoes autoxidation a relatively larger conformational alteration after binding CL, inducing higher peroxidase activity...
A nanoscale metal-molecule-semiconductor assembly (Ag/4-mercaptophenol/TiO2) has been fabricated over Au nanoparticle (NP) films as a model to study the interfacial charge transfer (CT) effects involved in Ag/MPH/TiO2. Due interaction between NPs and Ag NPs, some distinct differences occur SERS spectra. We also measured of Ag/MPH (4-mercaptophenol), Ag/MPH/TiO2, Au/Ag/MPH/TiO2 assemblies at excitation wavelengths 477, 514, 532, 633, 785 nm. found that changes CT process, caused by...
Surface-enhanced Raman spectroscopy (SERS) represents a powerful approach for studying the structure and reaction of proteins in fundamental applied sciences. The surface properties SERS-active materials determine important parameters such as enhancement ability, biocompatibility, electronic communication between supports proteins. Here, electron transfer (ET) Cyt c on noble metals transition is investigated by SERS spectroscopy. results here indicate that ET occurs from reduced state to...
A SERRS-based assay for thyrotropin-releasing hormone quantification coupled with the azo reaction was proposed simplicity, rapidness, selectivity and ultrahigh sensitivity.
Dendrobium nobile Lindl. (DNL) is effective for the treatment of alcoholic liver disease (ALD), but underly mechanism still unclear.This research aimed to investigate effects and aqueous extract Lindl (AEDNL) in ALD rats based on a metabolomics approach.In this study, 18 Sprague-Dawley male were randomly divided into control, model, AEDNL groups (n=six). Rats group given (152 mg/kg) intragastric administration from first day 30 consecutive days. From 15 30, model 30% ethanol (10 ml/kg) after...
Objective To examine the effects of sodium pyruvate (SP) on metabolic acidosis.Methods For in vivo experiments, we evaluated SP an ammonium chloride (NH4Cl)-induced hyperchloremic acidosis rat model. was infused at overall doses 2, 4, and 6 mmol·kg− 1 for SP1, SP2, SP3 groups, respectively. Treatment with bicarbonate (SB) used as a positive control (2 1), treatment normal saline (NS) volume mL·kg− 1). Blood sampled from ophthalmic venous plexus pH, blood gases, electrolytes, glucose,...
ABSTRACT The clinical application of cantharidin (CTD) is seriously limited due to its nephrotoxicity. Therefore, this study aims investigate sensitive biomarkers for the evaluation and prediction nephrotoxicity induced by CTD in rat. A total 80 rats were randomly divided into four groups: control group three doses groups. After 0, 1, 5, 15, 28 days intragastric administration, rat serum urine collected biochemical indexes, then was used metabolomic analyses, kidney pathological...
Abstract Cantharidin (CTD) is an effective antitumor agent. However, it exhibits significant hepatotoxicity, the mechanism of which remains unclear. In this study, biochemical and histopathological analyses complemented with ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC‐MS/MS)‐based targeted metabolomic analysis bile acids (BAs) were employed to investigate CTD‐induced hepatotoxicity in rats. Sixteen male female Sprague–Dawley rats randomly divided into two...
Abstract Background Norcantharidin (NCTD) has multiple antitumor effects. However, NCTD can induce significant hepatotoxicity and the mechanism of is not clear for now. Objective This study aimed to explore in rat by ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight (Q-TOF)-MS (UPLC/Q-TOF-MS) metabolomics. Results Serum biochemical indices including alanine aminotransferase (ALT) total bilirubin (T-BIL) were significantly increased. Histopathological ultrastructure...
Objective: The study aimed to analyze the core active compounds and potential mechanism of Shuganning injection (SGNI) through network pharmacology with biological experiments. Methods: Active targets SGNI were screened from Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP) Targetnet database, whereas liver disease-related identified Genecards Online Mendelian Inheritance in Man databases. “compound-target” “protein-protein interaction” networks...
A sensitive gas chromatography-mass spectroscopy method was established for the determination of cantharidin (CTD) in rat plasma and liver homogenates. During experiment, rats were randomly divided into two groups (low, high) administered aqueous extract Mylabris compound 7 days. Then, tissue samples taken at different time points to study pharmacokinetics distribution CTD rats. The selected reaction monitoring transitions clofibrate (internal standard) m/z 128 → 85 169 141, respectively....
Abstract The interaction of cytochrome c (Cyt c) with cardiolipin (CL) is believed to play an important role in the initial events apoptosis. Herein, we investigate structural changes CL‐bound Fe 2+ Cyt and correlation release through surface‐enhanced Raman spectroscopy (SERS) on nickel substrates. SERS results together molecular dynamics simulation reveal that undergoes autoxidation a relatively larger conformational alteration after binding CL, inducing higher peroxidase activity...