A5020824277- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Veterinary medicine and infectious diseases
- Leptospirosis research and findings
- Hepatitis Viruses Studies and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Neurological diseases and metabolism
- NF-κB Signaling Pathways
- Viral Infections and Immunology Research
- Immunodeficiency and Autoimmune Disorders
- Language Development and Disorders
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Blood disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Bacteriophages and microbial interactions
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini"
2013-2023
University of Bari Aldo Moro
2017
University of Minnesota
2015
University of Brescia
2009-2012
Brescia University
2011
It has been recently demonstrated that the 43-kDa transactive response (TAR)-DNA-binding protein (TARDBP) is neuropathological hallmark of Frontotemporal Dementia (FTD) with ubiquitin-positive and tau-negative inclusions. Large series FTD patients without motor neuron disease have previously analysed, but no TARDBP mutation was identified. The aim present study to evaluate whether gene mutations may be associated FTD. We report a pathogenetic causative behavioural variant (bvFTD). An aged...
Abstract Porcine epidemic diarrhea virus (PEDV) has been detected sporadically in Italy since the 1990s. We report phylogenetic relationship of swine enteric coronaviruses collected during 2007–2014 and identify a drastic shift PEDV strain variability new coronavirus generated by recombination transmissible gastroenteritis PEDV.
Bats are natural reservoirs for many mammalian coronaviruses, which have received renewed interest after the discovery of severe acute respiratory syndrome (SARS) and Middle East (MERS) CoV in humans. This study describes identification molecular characterization alphacoronaviruses betacoronaviruses bats Italy, from 2010 to 2012. Sixty-nine faecal samples 126 carcasses were tested using pan-coronavirus RT-PCR. Coronavirus RNAs detected seven nine carcasses. A phylogenetic analysis...
The 43-kD transactive response (TAR)-DNA-binding protein (TARDBP) mutations have been demonstrated to be causative of sporadic and familial forms amyotrophic lateral sclerosis. More recently, these reported in cases frontotemporal lobar degeneration (FTLD). aim this study was evaluate the role TARDBP genetic variations a large sample consecutive patients with FTLD. A total 252 FTLD were investigated. Each subject had clinical neuropsychological evaluation brain imaging study. diagnosis...
Primary progressive aphasia (PPA) is a heterogeneous disorder characterized by language impairment. Polymorphisms within forkhead box P2 gene (FOXP2) have been associated with speech and Apolipoprotein E (APOE) genotype PRNP 129 codon status demonstrated to increase the risk of PPA, but contrasting results. In present study, we evaluated impact FOXP2, APOE genetic variations as factors and/or disease-modulators in PPA. 94 PPA patients 200 age-matched healthy controls were considered FOXP2...
Porcine Epidemic Diarrhoea Virus (PEDV) causes watery diarrhoea, dehydration, and a high mortality rate among suckling pigs. Recently, PEDV had large negative economic impact on the swine industries in Asia North America. In 2014, re-emerged many European countries, but most countries only reported few sporadic cases. Here, we report epidemic wave that occurred Italy from 2015 to 2017. During this time, was detected by real-time PCR 438 farms located mainly high-density pig production area...
Swine act as both maintenance and incidental hosts of pathogenic Leptospira spp. Here, a serological test was performed on 131,660 pig sera collected between 2002 2017 from 4715 farms in Northern Italy. A positivity rate 13.05% determined. Australis the most frequently identified serogroup (77.29%), followed by Pomona (18.47%), Tarassovi (1.51%) Icterohaemorrhagie (1.40%). Culture isolation real-time Polymerase chain reaction (PCR) were carried out 347 kidneys 470 clinical samples,...
The porcine epidemic diarrhea virus (PEDV) causes an acute and highly contagious enteric disease characterized by severe enteritis, vomiting, watery a high mortality rate in seronegative neonatal piglets. In the last few years, PED had large economic impact on swine industries Asia United States, 2014, PEDV also re-emerged Europe. Two main variants circulate worldwide but only S INDEL variant, considered mild strain, is spreading To gain insights into pathogenicity of this its viral load...
The FOXP2 gene is mutated in a severe monogenic form of speech and language deficits, but no study on the influence genetic variations within neurological disorders characterized by impairment available yet. In present stu
Porcine epidemic diarrhoea virus, strain CV777, was initially characterized in 1978 as the causative agent of a disease first identified UK 1971. This coronavirus has been widely distributed among laboratories and passaged both within pigs cell culture. To determine variability between different stocks PEDV sequencing full-length genome (ca. 28kb) performed 6 laboratories, using protocols. Not surprisingly, each full sequences were distinct from other reference sequence (Accession number...
<i>Background:</i> Ruling out predictors of survival in frontotemporal lobar degeneration (FTLD) is a clinical challenge for defining disease outcomes and monitoring therapeutic interventions. Little known about determinants FTLD. <i>Objective:</i> The aim the present study was to identify whether genetic are key, not only as risk factors but <i>Methods:</i> Ninety-seven FTLD patients were considered study. A evaluation standardized assessment carried out....
It is important to be able detect and differentiate between distinct porcine enteric coronaviruses that can cause similar diseases. However, the existence of naturally occurring recombinant such as swine coronavirus (SeCoV) give misleading results with currently used diagnostic methods. Therefore, we have developed validated three duplex real-time quantitative RT-PCR assays for simultaneous detection of, differentiation between, epidemic diarrhea virus (PEDV) SeCoV. Transmissible...
Brain-derived neurotrophic factor (BDNF) promotes several functions in neurons and modulates neurotransmissions, especially hippocampal regions. Frontotemporal lobar degeneration (FTLD) has a strong genetic background, but risk factors associated with sporadic disease are unknown. Hippocampal involvement is frequently observed FTLD. The aims of this study were: i) to evaluate if BDNF variations an increased developing FTLD; ii) assess the neuroimaging profiles polymorphisms. Ninety-one FTLD...
In 2011, a group A rotavirus was isolated from the brain of fox with encephalitis and neurologic signs, detected by rabies surveillance in Italy. Intracerebral inoculation homogenates into mice fatal. Genome sequencing revealed heterologous avian origin, which could provide model for investigating neurovirulence.
Wild boar ( Sus scrofa ) is considered a potential source of several viral and bacterial pathogens that represent risk to humans other mammals. Among these the spirochete genus Leptospira causes Leptospirosis, neglected zoonotic disease. This study investigates presence antibodies against pathogenic spp. serovars in wild different areas Lombardy region (northern Italy) factors associated with its specific population. Blood tissue samples from boars were collected 2008 2013 during wildlife...
Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) are in the spectrum of tauopathies recognized to have a strong genetic background. It has been widely reported that MAPT tau haplotype H1 is risk factor both condit
It is important to be able detect and differentiate between distinct porcine enteric coronaviruses that can cause similar diseases. However, the existence of naturally occurring recombinant such as swine coronavirus (SeCoV) give misleading results with currently used diagnostic methods. Therefore, we have developed validated three duplex real-time quantitative RT-PCR assays for simultaneous detection of, differentiation between, epidemic diarrhea virus (PEDV) SeCoV. Transmissible...
In this study, we report the detection of a case Swine enteric Coronavirus (SeCoV) in Northern Italy. The complete genome sequence 28,081 nucleotides was obtained. This strain had nucleotide identity 98.15 to 98.45% with SeCoV circulating Europe during 1993-2015, but it also displayed unique genetic features.
Abstract In 2011, a group A rotavirus was isolated from the brain of fox with encephalitis and neurologic signs, detected by rabies surveillance in Italy. Intracerebral inoculation homogenates into mice fatal. Genome sequencing revealed heterologous avian origin, which could provide model for investigating neurovirulence.