A5103192765- Transcranial Magnetic Stimulation Studies
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Stress Responses and Cortisol
- Neuroscience and Neural Engineering
- Nerve injury and regeneration
- Spatial Neglect and Hemispheric Dysfunction
- Genetics and Neurodevelopmental Disorders
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
- Neurological Disorders and Treatments
- Cognitive Abilities and Testing
- Neural dynamics and brain function
- Vestibular and auditory disorders
- Stroke Rehabilitation and Recovery
- Neurobiology of Language and Bilingualism
- Dementia and Cognitive Impairment Research
- Motor Control and Adaptation
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
University of Regensburg
2020-2021
University of Brescia
2009-2016
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2015
Vita-Salute San Raffaele University
2007
This study aimed to assess whether non-invasive brain stimulation with transcranial alternating current at gamma-frequency (γ-tACS) applied over the precuneus can improve episodic memory and modulate cholinergic transmission by modulating cerebral rhythms in early Alzheimer's disease (AD).In this randomized, double-blind, sham controlled, crossover study, 60 AD patients underwent a clinical neurophysiological evaluation including assessment of pre post minutes treatment γ-tACS targeting or...
ARX loss-of-function mutations cause X-linked lissencephaly with ambiguous genitalia (XLAG), a severe neurological condition that results in profound brain malformations, including microcephaly, absence of corpus callosum, and impairment the basal ganglia. Despite such dramatic defects, their nature origin remain largely unknown. Here, we used Arx mutant mice as model to characterize cellular molecular mechanisms underlying ganglia alterations. In these animals, early differentiation this...
The gene encoding the brain-derived neurotrophic factor (BDNF) has been demonstrated as a candidate for Alzheimer's disease-related depression (AD-D) susceptibility. Additionally, an association between AD-D and functional valine to methionine (V
Abstract The neuropeptide oxytocin (OXT) has generated considerable interest as potential treatment for psychiatric disorders, including anxiety and autism spectrum disorders. However, the behavioral molecular consequences associated with chronic OXT receptor (OXTR) activation have scarcely been studied, despite therapeutic long-term use of intranasal OXT. Here, we reveal that over two weeks increased anxiety-like behavior in rats, higher sensitivity females, contrasting well-known...
Corticobasal syndrome (CBS) is a clinical entity characterized by higher cortical dysfunctions associated with asymmetric onset of levodopa-resistant parkinsonism, dystonia and myoclonus. One the most typical distressful features CBS limb apraxia, which affects patients in their everyday life. Transcranial direct current stimulation (tDCS) non-invasive procedure stimulation, represents promising tool for cognitive enhancement neurorehabilitation. The present study investigated whether anodal...
Corticobasal Syndrome (CBS) is a neurodegenerative disorder that overlaps both clinically and neuropathologically with Frontotemporal dementia (FTD) characterized by apraxia, alien limb phenomena, cortical sensory loss, cognitive impairment, behavioral changes aphasia. It has been recently demonstrated transcranial direct current stimulation (tDCS) improves naming in healthy subjects language deficits.The aim of the present study was to explore extent which anodal tDCS over parietal cortex...
Brain-derived neurotrophic factor (BDNF) promotes several functions in neurons and modulates neurotransmissions, especially hippocampal regions. Frontotemporal lobar degeneration (FTLD) has a strong genetic background, but risk factors associated with sporadic disease are unknown. Hippocampal involvement is frequently observed FTLD. The aims of this study were: i) to evaluate if BDNF variations an increased developing FTLD; ii) assess the neuroimaging profiles polymorphisms. Ninety-one FTLD...
SUMMARY Recently, oxytocin (OXT) has generated considerable interest as potential treatment for psychiatric disorders, including general anxiety disorder or autism spectrum disorder. Therefore, knowledge on the involved molecular processes downstream of OXT receptor (OXTR) activation is indispensable. We reveal that alternative splicing corticotropin releasing factor 2α (CRFR2α) parallels increased anxiety-like behavior following chronic treatment, contrasting well-known anxiolysis acute...
Dementia with Lewy bodies (DLB) is characterized by a marked shift of electroencephalographic (EEG) power and dominant rhythm, from the α toward θ frequency range. Transcranial alternate current stimulation (tACS) non-invasive brain technique that allows entrainment cerebral oscillations at desired frequencies.