A5007643766- Aldose Reductase and Taurine
- Fuel Cells and Related Materials
- Membrane-based Ion Separation Techniques
- Advanced battery technologies research
- Conducting polymers and applications
- Luminescence and Fluorescent Materials
- Polyoxometalates: Synthesis and Applications
- Organic Light-Emitting Diodes Research
- Electrocatalysts for Energy Conversion
- Cannabis and Cannabinoid Research
- Organic Electronics and Photovoltaics
- X-ray Diffraction in Crystallography
- Advanced Battery Technologies Research
- Crystallization and Solubility Studies
- Eicosanoids and Hypertension Pharmacology
- Chemical Synthesis and Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Battery Materials and Technologies
- Synthesis and Biological Evaluation
- Prenatal Substance Exposure Effects
- Polyamine Metabolism and Applications
- Lanthanide and Transition Metal Complexes
- Free Radicals and Antioxidants
- Heme Oxygenase-1 and Carbon Monoxide
- Synthesis and Catalytic Reactions
Beijing Institute of Technology
2010-2022
Institute of Chemistry
2005
Chinese Academy of Sciences
2005
State Key Laboratory of Polymer Physics and Chemistry
2005
Quinoxalin-2(1H)-one based design and synthesis produced several series of aldose reductase (ALR2) inhibitor candidates. In particular, phenolic structure was installed in the compounds for combination antioxidant activity strengthening ability to fight against diabetic complications. Most 6 showed potent selective effects on ALR2 inhibition with IC50 values range 0.032-0.468 μM, 2-(3-(2,4-dihydroxyphenyl)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid (6e) most active. More significantly, 8...
Polyoxometalates (POMs), with powerful multi-electron transfer capability, have been applied as photocatalysts. The Cu&POM-based complex, composed of PMo<sub>12</sub> and 1,10-phenanthroline, has constructed a supramolecular framework through hydrogen bonding p-p interactions. complex exhibits excellent photocatalytic performance in the oxidation toluene photodegradation metronidazole. using Cu-PMo<sub>12</sub> was carried out high yield selectivity (100%) under low-energy conditions,...
Abstract A novel and facile synthesis of quinoxalinone derivatives was developed in which a wide range 3‐chloroquinoxalin‐2(1 H )‐ones as key intermediates can be generated chemo‐ regioselectively good yields from corresponding quinoxaline‐2,3(1 ,4 )‐diones. This new protocol is arguably superior, it allows the design preparation variety bioactive quinoxaline‐based compounds, are particularly effective treatment diabetes its complications. Through this procedure, class quinoxalinone‐based...
ARIs for diabetes: A series of 2-(3-benzyl-2-oxoquinoxalin-1(2H)-yl)acetic acid derivatives were designed and synthesized as inhibitors aldose reductase (AR), a novel target the treatment diabetes complications. Most proved to be potent selective, with IC50 values in low nanomolar micromolar range.
A series of novel benzothiadiazine 1,1-dioxide derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Of these derivatives, 17 compounds, having a substituted N2-benzyl group N4-acetic acid on the benzothiadiazine, found to be potent selective reductase inhibitors in vitro with IC50 values ranging from 0.032 0.975 μM. 9m proved most active vitro. The eight top-scoring compounds coming test ALR2 inhibition then vivo, whereby three 9i, 9j, 9m,...
ABSTRACT Simultaneously improving the proton conductivity and mechanical properties of a polymer electrolyte membrane is considerable challenge in commercializing exchange fuel cells. In response, we prepared new series miscible blends thus corresponding crosslinked membranes based on highly sulfonated poly(ether ether ketone) polybenzimidazole. The blended showed more compact structures, due to acid‐base interactions between two constituents, improved morphological properties. Further...
Abstract The development and progression of chronic complications in diabetic patients, such as retinopathy, nephropathy, neuropathy, cataracts, stroke, are related to the activation and/or overexpression aldose reductase (ALR2), which is a member aldo–keto superfamily. A structure–activity relationship study focused on C7 position 1,2,4‐benzothiadiazine‐1,1‐dioxide derivatives was pursued an attempt discover ALR2 inhibitors with enhanced potency selectivity. These studies led series new...
Intent on developing efficient proton exchange membranes used for direct methanol fuel cells as well hydrogen cells, a series of based sulfonated polyetheretherketone and polyphosphazene‐graft copolymers is prepared by cross‐linking reaction because the former material has good enough mechanical property, while latter excellent in transfer. The cross‐linked combine advantages two kinds polymers. Among them, membrane poly[(4‐trifluoromethylphenoxy)(4‐methylphenoxy)phosphazene]‐g‐poly...
Abstract Polyphosphazenes containing perfluoroalkyl sulfonic acids (PSA-P) were synthesized by the copper-catalyzed coupling reaction of poly[(4-bromophenoxy)(phenoxy)phosphazene] with potassium 1,1,2,2-tetrafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy) ethanesulfonate. Two synthetic protocols have been developed to obtain polymers and 1, 10-phenanthroline was found benefit for improving efficiency reaction. The PSA-P membranes prepared solution casting showed excellent thermal stability,...
Co 4 (PW 9 ) 2 @GDY is composed of polyoxometalate (POM) and graphdiyne (GDY), which exhibits excellent electrochemical performance for oxygen evolution reaction. This due to its strong electron-transfer ability higher conductivity GDY.
A composite cluster [Co 5.7 Ni 2.3 W 12 O 42 (OH) 4 @FGDY] exhibited high performance for the electrochemical oxygen evolution reaction with low potentials at current density and long stability.
Three high-efficient green light iridium complexes were designed and prepared. Thermal stabilities, electrochemical properties, electroluminescence performances substituents effects are presented discussed in this study.
In order to obtain new emitting materials with an improved thermal stability and the luminescence efficiency, we designed a type of cyclic phosphazene based blue light-emitting dendrimers, in which rigid spherical core is chemically bonded anthracene branches.Three synthesis routes has been studied for preparation target molecule.