Quinoxalin-2(1H)-one based design and synthesis produced several series of aldose reductase (ALR2) inhibitor candidates. In particular, phenolic structure was installed in the compounds for combination antioxidant activity strengthening ability to fight against diabetic complications. Most 6 showed potent selective effects on ALR2 inhibition with IC50 values range 0.032-0.468 μM, 2-(3-(2,4-dihydroxyphenyl)-7-fluoro-2-oxoquinoxalin-1(2H)-yl)acetic acid (6e) most active. More significantly, 8...

Background: Structure–activity relationship (SAR) is considered to be an effective in silico approach when discovering potential antagonists for breast cancer due gene mutation. Major challenges are faced by conventional SAR predicting novel the discovery of diverse antagonistic compounds. Methodologyand Results: In antagonists, a multistep screening phytochemicals isolated from seeds Citrus sinensis plant was applied using feasible complementary methodologies. A three-dimensional...

Abstract Pomegranate ( Punica granatum ) is one of the oldest well-known edible fruits, which has originated in Central Asia but now it a widespread geographical distribution throughout world. Phytochemicals are isolated from pomegranate peels that show different nutritional and pharmaceutical properties. Absorption, distribution, metabolism, excretion, toxicity (ADME-Tox) were performed to check adsorption, compounds. Previous studies mainly focused on physico-chemical properties other...

<p>The epidemic of Novel COVID-19 was<b> </b>reported in India January 2020 and increased day by due to the movement people from abroad then different parts country. The has been declared as pandemic because its high transmission rate coved more than 2010 countries world. Under this scenario when there is no medicine for treatment, only solution problem break chain restrict count infected people. To contain a coronavirus (COVID-19) outbreak, Government announced nationwide...

In the twenty-first century, emergence of COVID-19 as a highly transmissible pandemic disease caused by SARS-CoV-2 posed significant threat to humanity.

The rise in the frequency of liver cancer all over world makes it a prominent area research discovery new drugs or repurposing existing drugs. This article describes pharmacophore-based structure-activity relationship (3DQSAR) on secondary metabolites Alhagi maurorum to inhibit human cell lines Hepatocellular carcinoma (HCC) and hepatoma G2 (HepG2) which represents molecular level understanding for isolated phytochemicals maurorum. definite features, such as hydrophobic regions, average...

Objective: To compare the frequency of uterine atony in laboring women who are given prophylactic Calcium Chloride versus did not receive it. Study design: Quasi-experimental study Place and duration study: Pakistan Emirates Military Hospital Rawalpindi, from Oct 2023 to Mar 2024. Methodology: After getting approval hospitals ethical committee, eighty-two gravid at term, were risk development recruited. The participants then divided into two groups. 41 patients placed Group-A, while Group-C....

To compare the efficacy of low-level light therapy (LLLT) and intense pulsed (IPL) in treatment patients with dry eyes. Quasi-experimental study. Place Duration Study: Department Ophthalmology, The Armed Forces Institute Rawalpindi, Pakistan, from July to December 2022. There were 36 eyes assigned two groups receiving either LLLT (Equinox >Eye machine) or IPL (E-Eye therapy. They given three sessions at 0th, 4th, 6th weeks over a period 6 effects noted. parameters evaluated before first...

Objective: To determine the effectiveness of a modified early obstetric warning system (MEOWS) in determining probability maternal morbidity during Peripartum Period. Study Design: Cross-sectional observational study.Place and Duration Study: This was conducted at Department Obstetrics Gynecology, District Headquarters Hospital (DHQ) Rawalpindi, Pakistan from October 2022 to 2023.Methods: The study sample consisted pregnant women, 127 each 3 high-risk categories postpartum hemorrhage,...

Nursing education is essential for developing skilled healthcare practitioners, and Students' educational experiences outcomes are significantly impacted by their learning environment. Objective: To find out how Islamabad, Pakistan's nursing schools' students feel about the supportive Methods: In a descriptive cross-sectional study, 220 enrolled in Post-Registered Nurse Bachelor of Science (PRBSN) Generic (GBSN) programs participated. Responses were collected anonymously using Dundee Ready...

A series of novel benzothiadiazine 1,1-dioxide derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Of these derivatives, 17 compounds, having a substituted N2-benzyl group N4-acetic acid on the benzothiadiazine, found to be potent selective reductase inhibitors in vitro with IC50 values ranging from 0.032 0.975 μM. 9m proved most active vitro. The eight top-scoring compounds coming test ALR2 inhibition then vivo, whereby three 9i, 9j, 9m,...

In our present work, we emphasized on the potential of barbituric acid (1) derivatives as drugs like anti-bacterial, hypnotic, sedative, anti-microbial and antifungal agents. As naturally occurring, is inactive but in derivative form, it has a large number medicinal uses nowadays, great demand pharmaceutical industry. Barbituric wide range applications synthesis diverse class compounds heterocyclic, carbocyclic, synthetic alkaloids, due to its broad-spectrum applications, acquired position...

The epidemic of Novel COVID-19 was reported in India January 2020 and increased day by due to the movement people from abroad then different parts country. has been declared as pandemic because its high transmission rate coved more than 2010 countries world. Under this scenario when there is no medicine for treatment, only solution problem break chain restrict count infected people. To contain a coronavirus (COVID-19) outbreak, Government announced nationwide lockdown with effect midnight 24...

Breast cancer covers a large area of research because its prevalence and high frequency all over the world. This study is based on drug discovery against breast from series imidazole derivatives. A 3D-QSAR activity atlas model was developed by exploring dataset computationally, using machine learning process Flare. The compounds divided into active inactive according to their biological structural similarity with reference drug. obtained PLS regression provided an acceptable r2 = 0.81 q2...

Breast cancer is a major issue of investigation in drug discovery due to its rising frequency and global dominance. Plants are significant natural sources for the development novel medications therapies. Medicinal mushrooms have many biological response modifiers used treatment physical illnesses. In this research, database 89 macro-molecules with anti-breast activity, which were previously isolated from literature, has been selected three-dimensional quantitative structure–activity...

Flavonoids demonstrate beneficial effects on human health because flavonoids contain important biological properties. Kaempferol is a flavonol, type of flavonoid found in eatable plants and usually employed ancient drugs (