A5074726411- Computational Drug Discovery Methods
- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Multicomponent Synthesis of Heterocycles
- Fungal Biology and Applications
- Sesquiterpenes and Asteraceae Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Diverse Scientific Research Studies
- Free Radicals and Antioxidants
- Phytochemistry and Bioactivity Studies
- Plant biochemistry and biosynthesis
- Pharmacological Effects of Natural Compounds
- Antibiotic Use and Resistance
- Moringa oleifera research and applications
- SARS-CoV-2 and COVID-19 Research
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and biological activity of medicinal plants
- Pharmaceutical Economics and Policy
- Ethnobotanical and Medicinal Plants Studies
- Berberine and alkaloids research
- Pomegranate: compositions and health benefits
Government College Women University Faisalabad
2017-2025
Government College Women University Sialkot
2017-2024
Post Graduate Institute of Medical Education and Research
2014-2024
University Of Information Technology
2022
Government College University, Faisalabad
2020
Islamia University of Bahawalpur
2010-2017
University of Pisa
2013-2014
Cigarette smoke-mediated oxidative stress induces an inflammatory response in the lungs by stimulating release of proinflammatory cytokines. Chromatin remodeling due to histone acetylation and deacetylation is known play important role transcriptional regulation genes. The aim this study was investigate molecular mechanism(s) responses caused cigarette smoke extract (CSE) human macrophage-like cell line MonoMac6 whether treatment these cells with antioxidant glutathione (GSH) monoethyl...
Heterocyclic compounds with oxazole and imidazole rings in their structure have disclosed momentous biological aptitudes. Taking into account superlative attributes, the present study was designed to introduce a new synthetic scheme make derivatives tremendous futuristic pharmacological potentialities. Series of Oxazolones were synthesized by using substituted benzaldehyde benzyl halides produce respective 1 (a–d) which further reacted hippuric acid yield oxazolones 2 (a–e). Newly then...
Introduction: Africa faces immense food and health insecurity challenges, a problem partly attributed to loss waste during postharvest handling distribution. In the context of research meet sustainable development goals, this project specifically addressed ripe indigenous eggplant (Solanum anguivi lam) fruit called “Igba Yinrin” by Yoruba in South-West Nigeria, which is usually discarded farms. The study was carried out on unripe fruits better understand their value comparing effects...
Background: Structure–activity relationship (SAR) is considered to be an effective in silico approach when discovering potential antagonists for breast cancer due gene mutation. Major challenges are faced by conventional SAR predicting novel the discovery of diverse antagonistic compounds. Methodologyand Results: In antagonists, a multistep screening phytochemicals isolated from seeds Citrus sinensis plant was applied using feasible complementary methodologies. A three-dimensional...
Abstract Pomegranate ( Punica granatum ) is one of the oldest well-known edible fruits, which has originated in Central Asia but now it a widespread geographical distribution throughout world. Phytochemicals are isolated from pomegranate peels that show different nutritional and pharmaceutical properties. Absorption, distribution, metabolism, excretion, toxicity (ADME-Tox) were performed to check adsorption, compounds. Previous studies mainly focused on physico-chemical properties other...
In the twenty-first century, emergence of COVID-19 as a highly transmissible pandemic disease caused by SARS-CoV-2 posed significant threat to humanity.
The rise in the frequency of liver cancer all over world makes it a prominent area research discovery new drugs or repurposing existing drugs. This article describes pharmacophore-based structure-activity relationship (3DQSAR) on secondary metabolites Alhagi maurorum to inhibit human cell lines Hepatocellular carcinoma (HCC) and hepatoma G2 (HepG2) which represents molecular level understanding for isolated phytochemicals maurorum. definite features, such as hydrophobic regions, average...
In our present work, we emphasized on the potential of barbituric acid (1) derivatives as drugs like anti-bacterial, hypnotic, sedative, anti-microbial and antifungal agents. As naturally occurring, is inactive but in derivative form, it has a large number medicinal uses nowadays, great demand pharmaceutical industry. Barbituric wide range applications synthesis diverse class compounds heterocyclic, carbocyclic, synthetic alkaloids, due to its broad-spectrum applications, acquired position...
Breast cancer covers a large area of research because its prevalence and high frequency all over the world. This study is based on drug discovery against breast from series imidazole derivatives. A 3D-QSAR activity atlas model was developed by exploring dataset computationally, using machine learning process Flare. The compounds divided into active inactive according to their biological structural similarity with reference drug. obtained PLS regression provided an acceptable r2 = 0.81 q2...
The current study was carried out to reveal the chemical profile and biological screening of Heliotropium dasycarpum Ledeb, as well feasibility its industrial application. Therefore, methanolic extract (HdM) H. divided into n-hexane (HdH), ethyl acetate (HdE) water (HdW) soluble fractions. All fractions were inactive against acetylcholinesterase (AChE) enzyme, 3T3 HeLa cell lines, but showed immunomodulatory effect up 37 %. HdE fraction further displayed significant anti-urease activity with...
Hibiscus rosa-sinensis is an attractive, ever-blossoming, and effortlessly available plant around the globe. The fabulous flowers of H. enjoy a significant status in folk medicine throughout world comprise range phyto constituents due to which this splendid flower owns numerous biological pharmaceutical activities like antioxidant, antifungal, antimicrobial, anti-inflammatory, antipyretic, antidiabetic, antifertility activity. Considering this, column chromatographic isolation...
Breast cancer is a major issue of investigation in drug discovery due to its rising frequency and global dominance. Plants are significant natural sources for the development novel medications therapies. Medicinal mushrooms have many biological response modifiers used treatment physical illnesses. In this research, database 89 macro-molecules with anti-breast activity, which were previously isolated from literature, has been selected three-dimensional quantitative structure–activity...