A5031526840- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Bioactive Compounds
- Microbial Natural Products and Biosynthesis
- Click Chemistry and Applications
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Sesquiterpenes and Asteraceae Studies
- Cholinesterase and Neurodegenerative Diseases
- Biological Activity of Diterpenoids and Biflavonoids
- Chemical synthesis and alkaloids
- Bioactive natural compounds
- Fungal Biology and Applications
- Marine Sponges and Natural Products
- Natural Antidiabetic Agents Studies
- Traditional Chinese Medicine Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Plant biochemistry and biosynthesis
- Computational Drug Discovery Methods
- Ethnobotanical and Medicinal Plants Studies
- Phytochemical compounds biological activities
Islamia University of Bahawalpur
2015-2024
Bahawal Victoria Hospital
2017
University of Göttingen
2012
Pakistan Council of Scientific & Industrial Research
2005-2008
Karachi Medical and Dental College
2005-2007
International Center for Chemical and Biological Sciences
2002-2005
University of Karachi
2002-2005
Abstract NIMA related Kinases (NEK7) plays an important role in spindle assembly and mitotic division of the cell. Over expression NEK7 leads to progression different cancers associated malignancies. It is becoming next wave targets for development selective potent anti-cancerous agents. The current study first comprehensive computational approach identify inhibitors protein. For this purpose, previously identified anti-inflammatory compound i.e., Phenylcarbamoylpiperidine-1,2,4-triazole...
Vascular endothelial growth factor (VEGF) is an angiogenic involved in tumor and metastasis. Gremlin has been proposed as a novel therapeutic pathway for the treatment of renal inflammatory diseases, acting via VEGFR 2 receptor. To date, most FDA-approved tyrosine kinase (TK) inhibitors have reported dual EGFR 2. The aim present study was to find potent selective inhibitor specifically cancer. Fourteen previously identified anti-inflammatory compounds i.e., 1, 3, 4 oxadiazoles derivatives by...
A mild and efficient route to tetraketones (2-22) has been developed by way of tetraethyl ammonium bromide (Et(4)N(+)Br(- )) mediated condensation dimedone (5,5-dimethylcyclohexane-1,3-dione, 1) with a variety aldehydes. All these compounds showed significant lipoxygenase inhibitory activity moderate strong antioxidant potential. Compounds 19 (IC(50) = 7.8 microM), 22 12.5 3 16.3 11 17.5 microM) 8 21.3 potential against (baicalein, IC(50) 22.4 microM). On the other hand compound 33.6 also...
Abstract Bractin A (=(2 S ,3 ,4 R ,5 E )‐2‐{[(2 )‐2‐hydroxydodecanoyl]amino}triacont‐5‐ene‐1,3,4‐triol; 1 ) and bractin B ,8 ‐ 2‐hydroxyhexacosanoyl]amino}pentadeca‐5,8‐diene‐3,4,15‐triol 1‐ O β D ‐glucopyranoside; 2 ), new sphingolipids, bractic acid (=(5 Z ,10 ,15 )‐2‐decyl‐4,7,8,12,13,17,18‐heptahydroxy‐20,23‐dioxopentacosa‐5,10,15‐trienoic acid; 3 a long‐chain polyhydroxy acid, were isolated from the whole plant Ajuga bracteosa along with four known diterpenoids 4 – 7 . Their structures...
The current study was carried out to reveal the chemical profile and biological screening of Heliotropium dasycarpum Ledeb, as well feasibility its industrial application. Therefore, methanolic extract (HdM) H. divided into n-hexane (HdH), ethyl acetate (HdE) water (HdW) soluble fractions. All fractions were inactive against acetylcholinesterase (AChE) enzyme, 3T3 HeLa cell lines, but showed immunomodulatory effect up 37 %. HdE fraction further displayed significant anti-urease activity with...
A new flavonoid, isorhamnetin-3-O-[-alpha-l-rhamnopyranosyl-(1 --> 3)]-beta-D-glucopyranoside (1), along with two known flavonoids 3'-O-methylorobol (2) and quercetin 3-O-beta-d-glucopyranoside (3), was isolated from Alhagi maurorum. Their structures were established the help of mass spectrometry, 1D 2D NMR spectroscopy, in comparison literature data. Compounds 1 2 exhibited moderate antioxidant activity 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay.
A new lignan rhamnoside, racemiside (1), has been isolated from the ethyl acetate-soluble fraction of Cotoneaster racemiflora, along with scopoletin (2), 7,8-dimethoxy-6-hydroxycoumarin (3), 3,3′,4′-tri-O-methylellagic acid (4), and cereotagloperoxide (5), reported for first time this species. All them showed profound antioxidative activities in DPPH assay.
The present work describes medicinal potential and secondary metabolic picture of the methanol extract (PP-M) Polygonum plebeium R.Br. its fractions; hexane (PP-H), ethyl acetate (PP-E) water (PP-W). In total bioactive component estimation, highest contents phenolic (89.38±0.27 mgGAE/g extract) flavonoid (51.21±0.43 mgQE/g were observed in PP-E, same fraction exhibited antioxidant DPPH (324.80±4.09 mgTE/g extract), ABTS (563.18±11.39 CUPRAC (411.33±15.49 FRAC (369.54±1.70 assays....
The current study elaborates the pharmacological potential of methanolic extract and its fractions stems Monotheca buxifolia based on thin-layer chromatography column analyses, exploiting biological phytochemical assays. results suggest that bioassay-guided isolation fractionation led to accumulation biologically active components in most resulted different compounds. Structural elucidation purified compounds was accomplished using spectroscopic one-dimensional (1H, 13C) two-dimensional NMR...
The phenolic compounds methyl 2-O-feruloyl-1a-O-vanillactate (1), caffeic anhydride (2), and trans 4-hydroxycyclohexyl-2-O-p-coumaroyl beta-D-glucopyranoside (3) have been isolated from the AcOEt-soluble fraction of Ehretia obtusifolia, along with rosmarinate (4) rosmarinic acid (5), which are reported for first time this species. Their structures were determined by means 1D- 2D-NMR techniques. Compounds 1-5 inhibited lipoxygenase in a concentration-dependent manner, Ki values ranging...
Species of the genus Phyllanthus are known for their medicinal values and many explored phytochemically. Some them produce phthalates which usually have antimicrobial properties. This paper deals with phytochemical investigation on muellerianus. As a result, five compounds, bis(2-ethyloctyl)phthalate (1), bis(2-ethylicosyl)phthalate (2), 3-friedelanone (3), beta-sitosterol (4), methyl gallate (5), been isolated characterized. Metabolites 1 2 new while 3-5 first time from this source....
Both members of the aldo-keto reductases (AKRs) family, AKR1B1 and AKR1B10, are over-expressed in various type cancer, making them potential targets for inflammation-mediated cancers such as colon, lung, breast, prostate cancers. This is first comprehensive study which focused on identification phenylcarbamoylazinane-1, 2,4-triazole amides (7a–o) inhibitors (AKR1B1, AKR1B10) via detailed computational analysis. Firstly, stability reactivity compounds were determined by using Guassian09...