A5010965377- Enzyme function and inhibition
- Adenosine and Purinergic Signaling
- Synthesis and biological activity
- Biochemical and Molecular Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Multicomponent Synthesis of Heterocycles
- Synthesis and Catalytic Reactions
- Alkaline Phosphatase Research Studies
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Molecular Sensors and Ion Detection
- Synthesis and Characterization of Heterocyclic Compounds
- Ionic liquids properties and applications
- Synthesis and Biological Evaluation
- Analytical Chemistry and Sensors
- Microbial Applications in Construction Materials
- Carbohydrate Chemistry and Synthesis
- Click Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- Marine Sponges and Natural Products
- Metal complexes synthesis and properties
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Phenothiazines and Benzothiazines Synthesis and Activities
Forman Christian College
2016-2025
Universiti Malaysia Terengganu
2021
Universiti Sains Malaysia
2021
University of Lahore
2015-2020
COMSATS University Islamabad
2013
University of the Punjab
2010-2011
Abstract The pathogenesis of Alzheimer's disease (AD) is multifaceted, and more than one factor deemed responsible for its genesis progression. Hence, the multi‐target approach seems plausible en route to development therapeutics targeting in particular, other neurological disorders, general. Among major factors AD are acetylcholinesterase monoamine oxidase enzymes. Acetylcholine an important neurotransmitter that plays a role processing memory learning. Deficiency this observed patients AD;...
New thiosemicarbazide-linked acridines 3a-c were prepared and investigated as chemosensors for the detection of biologically environmentally important anions. The compounds found selective fluoride (F-) with no affinity other anions, i.e. -OAc, Br-, I-, HSO4-, SO42-, PO43-, ClO3-, ClO4-, CN- SCN-. Further, upon gradual addition a anion source (tetrabutylammonium fluoride), well-defined change in colour solution probes was observed. anion-sensing process studied detail via UV-visible...
A series of sulfonamide derivatives incorporating substituted 3-formylchromone moieties were investigated for the inhibition three human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, and VI. All these compounds, together with clinically used acetazolamide, as inhibitors physiologically relevant isozymes II (cytosolic), VI (secreted isoform). These sulfonamides showed effective against all isoforms KI's in range 0.228 to 118 µM. Such molecules can be leads discovery novel CA other...
1,4-Diazabicyclo[2.2.2]octane (DABCO)-based ionic liquids (ILs) 2-4 were synthesized by the N-alkylation of DABCO using alkyl halides varying chain lengths (C2, C5, and C7). The N-alkylated DABCO-ILs mixed with polyethylene glycols (PEGs) molar masses as hydrogen bond donors (HBDs) to prepare new deep eutectic solvents (DESs). These DABCO-PEG-based DESs successfully employed for synthesis a variety indoles 7a-7h (by Fischer indole synthesis) 1H-tetrazoles 9a-9i click chemistry). For...
Abstract Self‐assembled supramolecular pH‐responsive hydrogels of carboxymethyl chitosan (CMCh) and the trilacunary heteropolytungstate salt Na 12 [α‐P 2 W 15 O 56 ].24H generating free polyanion P in solution, have been synthesized via electrostatic interactions. Benzoyl peroxide (BPO) was used as initiator for grafting poly (methacrylic acid) on polymer skeleton. The developed transparent were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy...