A5037785485- Computational Drug Discovery Methods
- Insect Pest Control Strategies
- Essential Oils and Antimicrobial Activity
- Cholinesterase and Neurodegenerative Diseases
- Aldose Reductase and Taurine
- Enzyme function and inhibition
- Synthetic Organic Chemistry Methods
- Synthesis and biological activity
- Marine Sponges and Natural Products
- Phytochemicals and Antioxidant Activities
- Metal complexes synthesis and properties
- Piperaceae Chemical and Biological Studies
- Molecular Sensors and Ion Detection
- Adenosine and Purinergic Signaling
- Alkaline Phosphatase Research Studies
- Eicosanoids and Hypertension Pharmacology
- Chemical synthesis and alkaloids
- Microbial Natural Products and Biosynthesis
- Natural Antidiabetic Agents Studies
- Microbial Applications in Construction Materials
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bioactive Natural Diterpenoids Research
- Biochemical and Molecular Research
- Biochemical effects in animals
- Petroleum Processing and Analysis
Universiti Malaysia Terengganu
2013-2025
Universiti Sains Malaysia
2021
Forman Christian College
2021
Institute of Marine Biotechnology
2013
University of Nottingham
2007
Monklands Hospital
1996
The peels extracted from various citrus species are major source of phenols, flavonoids and anti-microbial agents. purpose this study was a detailed investigation the phytochemical pharmacological character ethanolic (80%), methanolic acetone extracts peel local variants orange (lemon, grape fruit, mousami, fruiter, shikri malta). were studied to find out total phenolic contents (TPC), (TF) present. antioxidant activities assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging effect,...
Tyrosine threonine kinase (TTK) is the key component of spindle assembly checkpoint (SAC) that ensures correct attachment chromosomes to mitotic and thereby their precise segregation into daughter cells by phosphorylating specific substrate proteins. The overexpression TTK has been associated with various human malignancies, including breast, colorectal thyroid carcinomas. validated as a target for drug development, several inhibitors have discovered. In this study, ligand structure-based...
Abstract The pathogenesis of Alzheimer's disease (AD) is multifaceted, and more than one factor deemed responsible for its genesis progression. Hence, the multi‐target approach seems plausible en route to development therapeutics targeting in particular, other neurological disorders, general. Among major factors AD are acetylcholinesterase monoamine oxidase enzymes. Acetylcholine an important neurotransmitter that plays a role processing memory learning. Deficiency this observed patients AD;...
Abstract Anion sensing via small molecules as chemosensor carries unique significance in biological and environmental fields, where it offers several advantages over the traditional methods of ion sensing. In current study, receptor ‐ spacer fluorophore based coumarin thiosemicarbazones were synthesized investigated against different anions. The anion interaction with thiosemicarbazone receptors (ligands) was observed naked‐eye by using UV‐Visible, fluorescence 1 H NMR spectroscopic...
The use of pesticides is unavoidable in agricultural practices. This class chemicals highly toxic for the environment as well humans. present work was carried out to assess presence some (diafenthiuron, lufenuron, azoxystrobin, difenoconazole, and chlorothalonil) residues five very commonly used vegetables (eggplant, capsicum, apple gourd, cauliflower, sponge gourd). Matrix solid phase dispersion (MSPD) technique extract subsequently their quantification performed through high performance...
Inhibition of aldose reductase (ALR2) by using small heterocyclic compounds provides a viable approach for the development new antidiabetic agents. With our ongoing interest towards inhibition, we have synthesized and screened series thiazoline derivatives (5a-k, 6a-f, 7a-1 & 8a-j) to find lead as potential agent. The bioactivity results showed thiazoline-based compound 7b having benzyl substituent nitrophenyl substituent-bearing 8e were identified most potent molecules with IC50 values 1.39...
Coconut palms in Malaysia are infested by a destructive invasive pest, RPW since 2007, and the pest’s population is difficult to control. At present, control management mainly relies on use of monocrotophos, which administered trunk injection method. However, this pesticide can negatively impact human health ecosystem. Plant EO that be used as bio-pesticide highly recommended an alternative monocrotophos because its target-specific eco-friendly properties. The antifeedant activity eight...
The study was conducted to explore the anticholinesterase inhibition property of eugenol derived molecules. Ten derivatives were synthesized and evaluated for inhibitory activities against acetylcholinesterase (AChE) butyrylcholinesterase (BChE) by Ellman’s method. Most tested showed higher on BChE than AChE, however, their overall activity weak. In contrast, three (compounds 3,6,9) good AChE more 50% at 10 μg/mL. Among them, compound 9bearing a ethyl substituent para position benzoyl ring...
Orthopedic implants are an important tool in the treatment of musculoskeletal conditions and helped many patients to improve their quality life. Various inorganic-organic biocomposites have been broadly investigated particularly area load-bearing orthopedic/dental applications. Polyimide (PI) is a promising organic material shows excellent mechanical properties, biocompatibility, bio-stability, its elastic modulus similar human bone but it lacks bioactivity, which very for cell adhesion...
Amoebae of the genus
AbstractTo explore the new mode of action and reduce side effects, making conjugates existing drugs is becoming an attractive tool in realm medicinal chemistry. In this work, we exploited approach synthesized to assess their activities against enzymes involved different pathological conditions. Specifically, design involving acetylsalicylic acid sulfa drugs, validating newly crafted using techniques like IR, 1HNMR, 13CNMR, elemental analysis. These underwent assessment for ability inhibit...
Rhynchophorus ferrugineus or red palm weevil (RPW) is a destructive insect pest of major cultivated palms such as coconut, date and oil palm. One the control management RPW trunk injection using monocrotophos methamidophos, but these chemicals are found to affect ecosystems human health. Thus, we aimed determine bio-pesticide replace synthetic chemicals. We tested antifeedant activity three eugenol-based compounds potential agent against larvae in vitro condition for two weeks. All show...