Dengue virus (DENV) infections are rampant in tropical and subtropical regions of the world with millions people at risk. There is still no specific antiviral treatment available against these infections. Amongst different potential therapeutic targets, DENV protease considered an important target because its crucial role viral replication cycle. We reporting here a potent inhibitor, eugeniin (3), which has been isolated from cloves, along two other weaker inhibitors, isobiflorin (1)...

The COVID-19 pandemic has claimed more than a million lives worldwide within short time span. Due to the unavailability of specific antiviral drugs or vaccine, infections are causing panic both in general public and among healthcare providers. Therefore, an urgent discovery development effective drug for treatment is highly desired. Targeting main protease (Mpro) causative agent, SARS-CoV-2 great potential repurposing efforts. Published crystal structures Mpro further facilitated silico...

Myocardial infarction (MI) continues to be a predominant cause of mortality globally and is characterized by restricted therapeutic alternatives considerable adverse effects linked traditional treatments. This study assessed the cardioprotective properties Justicia adhatoda leaf extract against isoproterenol-induced myocardial in rats at GC, University Faisalabad. A total 32 albino Wistar were randomly allocated into four groups, with one group designated as control remaining groups...

Several new N-substituted 1,2-benzisothiazol-3(2H)-ones (BITs) were synthesised through a facile synthetic route for testing their anti-dengue protease inhibition. Contrary to the conventional multistep synthesis, we achieved structurally diverse BITs with excellent yields using two-step, one-pot reaction strategy. All compounds prescreened drug-like properties online Swiss Absorption, Distribution, Metabolism and Elimination (SwissADME) model, indicating favourable pharmaceutical...

Background: The trigger points are hyperirritable spots found usually in the muscle fascia or within taut bands of skeletal muscles that is painful on compression. Ischemic compression technique uses application sustained pressure with sufficient force and for long enough so as to slow down flow blood releasing tension out muscle. Strain counterstrain (SCS), also known positional release, a passive treatment relieves musculoskeletal pain dysfunction by indirect hand manipulation. Objectives:...

The rapid development of digital imaging and computer vision has extended the potential using these technologies in diagnosis human diseases. Medical image analysis is a non-invasive way to identify diseases which are usually manually marked by medical experts or automatically detected Computer-Aided Diagnostic (CAD) system. fundus images provide facts information about visual disorders (diabetic retinopathy, glaucoma, age-related macular degeneration, etc.), brain disease (Alzheimer's),...

Hepatitis B is a viral infection that causes major health problems worldwide. The hepatitis virus (HBV) and 1.2 million deaths per year globally infect more than two billion people. mainly affects the liver cirrhosis hypocellularity carcinoma. This study investigates diagnostic quality parameters of quantitative polymerase Chain Reaction (qPCR) enzyme-linked Immunosorbent Assay (ELISA) called enzyme immunoassay (EIA) for HBV Diagnosis. research was conducted at Molecular Biochemistry...

Ectomycorrhizal mushrooms belonging to Boletales (Basidiomycota) viz.Boletus edulis Bull, Hortiboletus rubellus Krombh and Suillus sibiricus Singer were selected evaluate their antifungal potential against some filamentous fungi viz.Aspergillus terreus Thom, Aspergillus niger Tiegh Rhizopus stolonifer Vuill.Extracts of these prepared in methanol various concentrations (0%, 1%, 1.5%, 2% 3%) tested pathogenic fungi.B. showed maximum decline (51-53%) the biomass R. stolonifer, S. Sibiricus...

Aim: To put efforts into promoting awareness about physical therapy in the specified population. Study design: It was an observational study. Place and duration: The duration of study 6 months carried out at Farooq Clinic Khushab. Methodology: An conducted among medical professionals based on a cross-sectional that with help self-structured questionnaire. Results: 63% house officers are well-aware have sufficient knowledge it. Some including cardiologists orthopedic surgeons said has now...

Using a simple and inexpensive sol-gel synthesis technique, Nd Cd doped copper chromite spinel nanoparticles (MxCu1-xCr2O4) with x=0.2, 0.4, 0.6, 0.8 were investigated. The crystal structure, elemental composition, nature, bandgap of the synthesized determined using XRD, EDS, SEM, Raman spectroscopy, Photoluminescence. As prepared calcined at 750°C for four hours, resulting in an increase average grain size from 37nm to 41nm, as demonstrated by XRD results. tells us about dislocation density...

The effort estimation needs to be done at early stages for successful delivery of software.Numerous models have been developed estimate software during the last decades, but a project is still challenging task and in case web based projects, it even harder.The selection programming language use different type objects i.e. hyperlinks, graphics, scripts etc. make process really complex.An model "WebMo", proposed projects inspired by COCOMO.This research presents non-algorithmic named...

Background: Chronic Kidney Disease (CKD) is associated with premature deaths, low quality of life, and high-cost medical treatment problems worldwide. When CKD does not cure, the End-Stage Renal (ESRD) emerges which required to be treated by Replacement Therapy (RRT) comprises a kidney transplant, or dialysis. Due dependency on family members, inability participate in economic activities fulfill various social responsibilities, such patients face many problems. Objectives: This study focused...

The COVID-19 detected in school, colleges and universities close the entire world. More than 1.2 billion kids were not class-room worldwide. Consequently; education has altered considerably, among characteristic increase of relearning, where by is under-taken distantly as well upon digital platform. Research recommended that online been revealed to raise maintenance knowledge, moreover acquire much time, denotation alter corona virus comprise cause might be now reside. Objective: To find out...

throughout the hilly areas of Pakistan especially in Murree and Islamabad.The production tulip is not carried out abundantly

Aim: To evaluate the combined effect of dry needling and strain counter technique in myofascial trigger points upper. Method: This randomized control trial study was conducted at Male Female physiotherapy ward, Outdoor, Mayo Hospital, Lahore. 28 patients who had complain taut band, tenderness referred pain fulfill inclusion criteria were enrolled this research via non-probability consecutive sampling which later allocated to two equal groups. Group A (n=14) experimental group treated by Dry...

Background: The education of college level badly affected by the Covid-19 because several reasons. educational activities are neglected and system is becoming unsatisfactory during deteriorated era Covid-19. Objectives: aim study to identify impact on academic achievement student district Faisalabad. Methodology: Total population will be 267 students graduation 4th year in colleges (Government College for women Karkhana bazar Faisalabad 101, Government Degree Samanabad 77 postgraduate...