A5083781877- Cancer Research and Treatments
- 3D Printing in Biomedical Research
- Viral Infectious Diseases and Gene Expression in Insects
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Bacterial Genetics and Biotechnology
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Advancements in Semiconductor Devices and Circuit Design
- RNA modifications and cancer
Inspire
2024
Harvard University
2020-2023
Johns Hopkins University
2020
Adoptive cell transfers have emerged as a disruptive approach to treat disease in manner that is more specific than using small-molecule drugs; however, unlike traditional drugs, cells are living entities can alter their function response environmental cues. In the present study, we report an engineered particle referred "backpack" robustly adhere macrophage surfaces and regulate cellular phenotypes vivo. Backpacks evade phagocytosis for several days release cytokines continuously guide...
Abstract Patient responses to autologous CD19 chimeric antigen receptor (CAR) T-cell therapies are limited by insufficient and inconsistent cellular functionality. Here, we show that controlling the precise level of stimulation during activation accommodate individual differences in donor cells will dictate functional attributes CAR-T cell products. The functionality products, consisting a diverse set blood samples derived from healthy donors, acute lymphoblastic leukemia (ALL), chronic...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSequence-specific proton NMR assignments and secondary structure in solution of Escherichia coli trp repressorCheryl H. Arrowsmith, R. Pachter, B. Altman, S. Iyer, O. JardetzkyCite this: Biochemistry 1990, 29, 27, 6332–6341Publication Date (Print):July 10, 1990Publication History Published online1 May 2002Published inissue 10 July 1990https://pubs.acs.org/doi/10.1021/bi00479a002https://doi.org/10.1021/bi00479a002research-articleACS...
Abstract Extracellular vesicles (EVs) are released by all cells and contain RNA protein from their cell of origin. EVs in biofluids could be used as diagnostic biomarkers to non-invasively report the state inaccessible cells, such neurons brain. As cerebrospinal fluid (CSF) plasma originating many different isolating type-specific measuring cargo help determine specific types. Here, we demonstrate an approach aiming immuno-isolate based on neuron-derived surface markers. We first developed a...
A synthetic auxotroph does not escape from biocontainment after evolution, demonstrating that life always find a way.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnusual dynamic features of the trp repressor from Escherichia coliC. H. Arrowsmith, J. Czaplicki, S. B. Iyer, and O. JardetzkyCite this: Am. Chem. Soc. 1991, 113, 10, 4020–4022Publication Date (Print):May 1, 1991Publication History Published online1 May 2002Published inissue 1 1991https://pubs.acs.org/doi/10.1021/ja00010a070https://doi.org/10.1021/ja00010a070research-articleACS PublicationsRequest reuse permissionsArticle...
Abstract Understanding the evolutionary stability and possible context-dependence of biological containment techniques is critical as engineered microbes are increasingly under consideration for applications beyond biomanufacturing. While batch cultures synthetic auxotrophic Escherichia coli previously exhibited undetectable escape throughout 14 days monitoring, long-term effectiveness auxotrophy unknown. Here, we report automated continuous evolution a auxotroph using custom chemostats that...