A5004146758- HIV Research and Treatment
- Molecular Sensors and Ion Detection
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Chemical Synthesis and Analysis
- Metal complexes synthesis and properties
- Supramolecular Chemistry and Complexes
- Analytical Chemistry and Sensors
- Pneumocystis jirovecii pneumonia detection and treatment
- Crystallography and molecular interactions
- Porphyrin and Phthalocyanine Chemistry
- Electrochemical sensors and biosensors
- Asymmetric Synthesis and Catalysis
- Coordination Chemistry and Organometallics
- Adenosine and Purinergic Signaling
- Synthetic Organic Chemistry Methods
- Receptor Mechanisms and Signaling
- Blood groups and transfusion
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and Properties of Aromatic Compounds
- Inorganic and Organometallic Chemistry
- Organometallic Complex Synthesis and Catalysis
- Chemical Reaction Mechanisms
University of Nevada, Reno
2013-2025
Saint Louis University
2017-2018
State University of New York
1990-2006
KU Leuven
2003-2006
Rega Institute for Medical Research
2003-2006
University of Stuttgart
2005-2006
Augusta University
2006
Pfizer (United States)
2004
RTI Health Solutions
2004
RTI International
2004
Since its discovery in the early seventies intermolecular Pauson-Khand reaction has made considerable progress towards a powerful synthetic method. This account describes major accomplishments with respect to reactivity, stereoselectivity and catalytic versions, which have been achieved over last decade summarizes mechanistic information being obtained by theoretical experimental studies.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHexagonal lattice hosts for urea. A new series of designed heterocyclic receptorsThomas W. Bell and Jia. LiuCite this: J. Am. Chem. Soc. 1988, 110, 11, 3673–3674Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 1988https://doi.org/10.1021/ja00219a060RIGHTS & PERMISSIONSArticle Views307Altmetric-Citations94LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article...
An artificial receptor has been designed to bind creatinine with a color change (chromogenic response) caused by proton transfer from one end of the other. The was synthesized and found extract water into chlorocarbon solvents. in organic layer is specific for relative other solutes, it selective sodium, potassium, ammonium ions. chromogenic mechanism revealed x-ray crystal structures creatinine, free receptor, complex, showing "induced fit" binding resulting electronic complementarity...
7-Hydroxy-6,7-dihydro-5 H -pyrolizine-1-carboxaldehyde is the major volatile component of scent organs in males two species Creatonotos (Lepidoptera, Arctiidae). The biosynthesis this presumed pheromone depends on presence pyrrolizidine alkaloids plants that are ingested by larvae. In addition, these secondary plant substances control morphogenesis organs. This morphogenetic effect an alkaloid has not been observed previously.
Abstract Graves’ hyperthyroidism (GH) is a condition in which autoantibodies chronically activate the thyrotropin (thyroid-stimulating hormone) receptor (TSHR). TSHR one of few G protein-coupled receptors (GPCRs) predicted to have signal peptide, making it potential target for cyclotriazadisulfonamide (CADA) compounds. We sought determine whether small-molecule drug that selectively induces nascent protein degradation could decrease expression vitro and vivo at therapeutically relevant...
To evaluate the anti-HIV-1 activity of cyclotriazadisulfonamide CADA against primary isolates in vitro and combination with approved anti-HIV drugs for potential synergy.Peripheral blood mononuclear cells (PBMC) were treated infected 16 different clinical isolates. After 8 days infection, median inhibitory concentration (IC50) was calculated from p24 viral antigen content supernatant. MT-4 HIV-1NL4.3 then cultured or other antiretroviral (i.e., several reverse transcriptase, protease entry...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTorands: rigid toroidal macrocycles. Calcium sequestration by a member of this new ligand classThomas W. Bell and Albert. FirestoneCite this: J. Am. Chem. Soc. 1986, 108, 25, 8109–8111Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://doi.org/10.1021/ja00285a049RIGHTS & PERMISSIONSArticle Views602Altmetric-Citations60LEARN ABOUT THESE METRICSArticle Views are the...
In eukaryotic cells, surface expression of most type I transmembrane proteins requires translation and simultaneous insertion the precursor protein into endoplasmic reticulum (ER) membrane for subsequent routing to cell surface. This co-translational translocation pathway is initiated when a hydrophobic N-terminal signal peptide (SP) on nascent emerges from ribosome, binds cytosolic recognition particle (SRP), targets ribosome-nascent chain complex Sec61 translocon, universally conserved...
9-Benzyl-3-methylene-1,5-di-<i>p</i>-toluenesulfonyl-1,5,9-triazacyclododecane (CADA) has been identified as a novel antiviral lead compound with significant anti-human immunodeficiency virus and herpesvirus 7 activity. Surprisingly, this selectively decreased the expression of CD4 glycoprotein, primary receptor needed for entry both viruses. Herein, we describe down-modulating potencies more than 25 CADA derivatives. Flow cytometric evaluation cellular in T cells demonstrated specific...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkylation of heteroaryl halides by 2:1 Grignard reagent/copper(I) mixtures. Synthesis alkylated octahydrodibenzo[b,j][1,10]phenanthrolinesThomas W. Bell, Lain Yen Hu, and Sanjay V. PatelCite this: J. Org. Chem. 1987, 52, 17, 3847–3850Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://doi.org/10.1021/jo00226a023RIGHTS & PERMISSIONSArticle Views3562Altmetric-Citations43LEARN...
The blue emission of M2biQ can be tuned to specific wavelengths throughout the visible region by changing identity cation it interacts with. These optical properties are observed in MeCN solution and solid state. White light is obtained using either proper ratio zinc ions or acid. Thus, acts as a nearly universal emitter (λem = 468–690 nm) with large Stokes shifts (116–306 nm, Δν̃ 7,042–11,823 cm–1). Full spectral profiles well quantum yields, lifetimes, crystal structures key RGB yellow...
The multistep syntheses of several bicyclic triamines are described, all which have an imbedded 1,5,9-triazacyclododecane ring. In 1,5,9-triazabicyclo[7.3.3]pentadecanes 12, 13, 15, and 16, two nitrogens bridged by three carbons. monoprotonated forms these highly stabilized a hydrogen-bonded network involving the bridge both bridgehead nitrogens, producing difference more than 8 pK(a) units in acidities their diprotonated forms. one- zero-carbon bridges 1,5,9-triazabicyclo[9.1.1]tridecane...
A highly preorganized, artificial receptor for guanidinium cations binds arginine with high affinity in polar solvents, even water! The X-ray crystal structure of its bis(N-ethylguanidinium) complex shows the formation hydrogen bonds between and guest (see picture). This observation explains strength formed dipeptide diarginine (K(d)=50 µM H(2)O).
In the complexation of neutral organic molecules, preorganization receptors can play a crucial role, as studies on new series hydrogen-bonding demonstrate. The receptor shown in complex right binds guanine derivatives [D6]DMSO/CDCl3 (1/4) with stability constant (Ka) greater than 1.9 × 105 M−1. comparison, more flexible host and same number primary sites is at least 4.1 kcalmol−1 less stable.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComplexation of benzamidinium by a new family artificial receptorsThomas W. Bell and Vincent J. SantoraCite this: Am. Chem. Soc. 1992, 114, 21, 8300–8302Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/ja00047a057https://doi.org/10.1021/ja00047a057research-articleACS PublicationsRequest reuse permissionsArticle Views203Altmetric-Citations18LEARN...
Abstract
The largest cycloarene derivative reported so far, the torand 1, is surprisingly readily accessible by CsOH-mediated cyclotrimerization. According to Macromodel calculations, 1 almost planar and binds guanidinium with formation of six ideal hydrogen bonds only slight change in conformation: UV spectra its complex are identical.