Tia N. Donaldson

ORCID: 0000-0003-4997-0385
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About
Contact & Profiles
Research Areas
  • Memory and Neural Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Prenatal Substance Exposure Effects
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Fatty Acid Research and Health
  • Sleep and Wakefulness Research
  • Birth, Development, and Health
  • Neuroendocrine regulation and behavior
  • Stress Responses and Cortisol
  • Alzheimer's disease research and treatments
  • Neuroscience of respiration and sleep
  • Cholinesterase and Neurodegenerative Diseases
  • Hearing Loss and Rehabilitation
  • Biotin and Related Studies
  • Circadian rhythm and melatonin
  • Tryptophan and brain disorders
  • Olfactory and Sensory Function Studies
  • Zebrafish Biomedical Research Applications
  • Neurology and Historical Studies
  • Cannabis and Cannabinoid Research
  • Animal Vocal Communication and Behavior
  • Adipose Tissue and Metabolism
  • Hearing, Cochlea, Tinnitus, Genetics

University of New Mexico
2016-2025

Northern Illinois University
2017-2019

Here, we review the basis of contextual memory at a conceptual and cellular level. We begin with an overview philosophical foundations traversing space, followed by theories covering material bases representations in hippocampus (engrams), exploring functional characteristics cells subfields within. Next, explore various methodological approaches for investigating engrams, emphasizing plasticity mechanisms. This leads us to discuss role neuromodulatory inputs governing these dynamic changes....

10.3389/fnmol.2024.1342622 article EN cc-by Frontiers in Molecular Neuroscience 2024-02-05

Episodic memories are temporally segmented around event boundaries that tend to coincide with moments of environmental change. During these times, the state brain should change rapidly, or reset, ensure information encountered before and after an boundary is encoded in different neuronal populations. Norepinephrine (NE) thought facilitate this network reorganization. However, it unknown whether drive NE release hippocampus and, if so, how relates changes hippocampal firing patterns. The...

10.7554/elife.105183 preprint EN 2025-01-31

Episodic memories are temporally segmented around event boundaries that tend to coincide with moments of environmental change. During these times, the state brain should change rapidly, or reset, ensure information encountered before and after an boundary is encoded in different neuronal populations. Norepinephrine (NE) thought facilitate this network reorganization. However, it unknown whether drive NE release hippocampus and, if so, how relates changes hippocampal firing patterns. The...

10.7554/elife.105183.1 preprint EN 2025-01-31

Prenatal alcohol exposure can produce disruptions in a wide range of cognitive functions, but it is especially detrimental to spatial navigation. In open environments, rodents organize their behaviors around centralized locations, termed home bases, from which they make circuitous and slow locomotor trips (progressions) into the rest environment. Open-field are organized even under darkened test conditions, suggesting role for self-motion cues (vestibular, motor, etc.). The impact moderate...

10.1037/bne0000589 article EN Behavioral Neuroscience 2024-04-18

Abstract Background Prenatal alcohol exposure (PAE) can produce deficits in a wide range of cognitive functions but is especially detrimental to behaviors requiring accurate spatial information processing. In open field environments, behavior organized such that animals establish “home bases” marked by long stops focused around one location. Progressions away from the home base are circuitous and slow, while progressions directed toward non‐circuitous fast. The impact PAE on organization has...

10.1111/acer.14813 article EN Alcoholism Clinical and Experimental Research 2022-03-22

Abstract Episodic memories are temporally segmented around event boundaries that tend to coincide with moments of environmental change. During these times, the state brain should change rapidly, or reset, ensure information encountered before and after an boundary is encoded in different neuronal populations. Norepinephrine (NE) thought facilitate this network reorganization. However, it unknown whether drive NE release hippocampus and, if so, how relates changes hippocampal firing patterns....

10.1101/2024.07.30.605900 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-07-30

The identification of protein aggregates as biomarkers for neurodegeneration is an area interest disease diagnosis and treatment development. In this work, we present novel super luminescent conjugated polyelectrolyte molecules ex vivo sensors tau-paired helical filaments (PHFs) amyloid-β (Aβ) plaques. We evaluated the use two oligo-p-phenylene ethynylenes (OPEs), anionic OPE12− cationic OPE24+, stains fibrillar pathology in brain sections transgenic mouse (rTg4510) rat (TgF344-AD) models...

10.3390/bios13020151 article EN cc-by Biosensors 2023-01-18
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