A5010295968- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- IoT and Edge/Fog Computing
- Neutrino Physics Research
- Cloud Computing and Resource Management
- Metaheuristic Optimization Algorithms Research
- Facility Location and Emergency Management
- Computational Physics and Python Applications
- Algorithms and Data Compression
- Autophagy in Disease and Therapy
- Luminescence Properties of Advanced Materials
- Blockchain Technology Applications and Security
- Berberine and alkaloids research
- Advanced Photocatalysis Techniques
- Perovskite Materials and Applications
- HIV/AIDS drug development and treatment
- Monoclonal and Polyclonal Antibodies Research
- Phytochemical Studies and Bioactivities
- HIV Research and Treatment
- Photonic and Optical Devices
- Optimization and Search Problems
- Advanced Manufacturing and Logistics Optimization
Tsinghua University
2007-2025
University of Science and Technology Liaoning
2023-2025
Hunan University
2023
Sun Yat-sen University
2023
Sun Yat-sen University Cancer Center
2023
Berberine, an isoquinoline alkaloid, is a traditional oriental medicine used to treat diarrhea and gastroenteritis. Recently, we reported that it could inhibit the growth of intestinal polyp in animals patients with familial adenomatous polyposis by downregulating β-catenin signaling. However, intracellular target mediating effects berberine remains elusive. Here, provide evidence inhibits function via directly binding unique region comprising residues Gln275, Arg316 Arg371 nuclear receptor...
Metabolic fitness of T cells is essential for their vitality, which largely dependent on the behavior mitochondria. The nature mitochondrial in tumor-infiltrating remains poorly understood. In this study, we show that mitofusin-2 (MFN2) expression positively correlated with prognosis multiple cancers. Genetic ablation Mfn2 CD8+ dampens metabolism and function promotes tumor progression. cells, MFN2 enhances mitochondria-endoplasmic reticulum (ER) contact by interacting ER-embedded...
GPCRs signal through both G protein pathways and β–arrestin pathways. Previous work suggests that β–arrestins bind to different modes, including core engagement tail engagement. Core competes with proteins terminates signaling, while can coexist proteins, mediating sustained intracellular activation of the receptor – a process dependent on high affinity between phosphorylated C-terminus receptor. In this study, we determined structure GPCR - β-arrestin-1 complex stabilized by an allosteric...
Approximately 1/3 of all clinical drugs exert their therapeutic effects by modulating the activity G protein-coupled receptors (GPCRs). Thus, there is a constant interest in finding novel ways to modulate GPCR activity. In this work, through newly established Survival Pressure Selection (SPS) method for high-throughput screening agonists, we discover that atazanavir functions as an agonist GPR119. Further studies suggest capable activating number Family A GPCRs, including β1 adrenergic...
The Internet of Things (IoT) has been growing quickly since the 5 G era arrived, which boosted quantity data stream and computational demands. Ultra-dense Edge Computing (UDEC) is a result popularity Mobile (MEC) Network (UDN), two vital technologies with bright futures. Task offloading viewed in UDEC network as successful strategy to offer mobile users low-latency flexible computing capabilities. However, edge cloud's constrained capacity users' dynamically shifting requirements present...
To optimize the deployment of nodes in Wireless Sensor Networks (WSN) and effectively control network node energy consumption, thereby improving quality perception services, a Transit search algorithm based on oscillation exploitation factor Roche limit is proposed. The limit-inspired approach enhances stellar phase algorithm, accelerating convergence rate mid-to-late stages iteration while ensuring adequate exploration solution space. Subsequently, five weakening development factors are...
We have observed the transport properties in magnetic tunnel junction with multilayered structure: (50 nm)/Al-O (1 nm)/CoFeB (5 nm)/Ta (10 nm)/Ru nm). The maximum normal tunneling magnetoresistance (TMR) ratio was found to be 12.4% at a temperature range around 100 K, and inverse TMR 3% of 5 K . decreases increasing until it reaches 50 whereby switches behavior. appearance low temperatures is attributed presence minority-spin density states (DOS) half-metal Fermi level present...
Our results showed that interchanging the V5 region between two clones completely swapped their neutralization sensitivity profiles, while exchanging loop D alone had minimal impact. Mutagenesis analysis revealed potential N-linked glycosylation site (PNGS) at position 460 in contributed to over 90% of observed resistance, other amino acid changes made no discernible differences. Furthermore, resistance were found positively correlate with VRC01 binding activity corresponding envelope...
We report on the physical mechanism underlying temperature dependence of phase retardation. Changes in refractive index and thickness wave plate are two main contributions to retardation variations. Temperature-dependent changes described by Sellmeier's equation. Constants this equation need be determined fits experimental data. A new high-precision instrument was used measure at various temperatures. Once determined, fitting can calculate any temperature, thus has implications for...
The p-Hub allocation problem is a classic in location assignment, which aims to optimize the network by placing Hub devices and allocating each demand node corresponding Hub. A mutation Transit search (TS) algorithm with introduction of black hole swallowing strategy was proposed solve problem. Firstly, mathematical model for established. Six operators specifically designed are introduced enhance algorithm’s ability escape local optima. Additionally, incorporated into TS so as accelerate its...
Abstract In current manufacture process of pebble fuel elements for HTGR, the green pebbles were first carbonized, then lathed and purified at high temperature. The whole heat treatment included two cycles heating cooling corresponding loading unloading processes, which took approximately 90 hours in total. order to reduce time energy consumed improve efficiency during process, a consecutive HTGR was established. newly established carbonized temperature continuously specific furnace. less...