A5078572140- Growth Hormone and Insulin-like Growth Factors
- Vascular Malformations and Hemangiomas
- Metabolism, Diabetes, and Cancer
- Pituitary Gland Disorders and Treatments
- Diet and metabolism studies
- Prenatal Screening and Diagnostics
- Health and Lifestyle Studies
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Digestive system and related health
- Neuroblastoma Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Adipose Tissue and Metabolism
- Fibroblast Growth Factor Research
- Cancer and Skin Lesions
- Lipid metabolism and disorders
- Folate and B Vitamins Research
- Congenital Ear and Nasal Anomalies
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Congenital Diaphragmatic Hernia Studies
- Genetic Syndromes and Imprinting
- Neuroendocrine Tumor Research Advances
- Neurobiology of Language and Bilingualism
- Parathyroid Disorders and Treatments
Universidade Federal de Sergipe
2017-2024
University of Lisbon
2004-2010
Villa Maria Hospital
2004
Reduced inflammation, increased insulin sensitivity, and protection against cancer are shared between humans mice with GH/IGF1 deficiency. Beyond hormone levels, miRNAs important regulators of metabolic changes associated healthy aging. We hypothesized that GH deficiency in alters the abundance circulating a subset those may overlap found GH-deficient mice. In this study, subjects untreated congenital isolated (IGHD; n = 23) control matched by age sex (n were recruited serum was collected...
GH and IGF-1 are crucial for attainment of normal body size regulation food intake, nutrient storage, insulin sensitivity. Enteroendocrine connections exist between the GH–IGF-1 axis insulin, ghrelin, glucagon-like peptide 1 (GLP-1). The status these in deficiency (GHD) is unknown. To study enteroendocrine before after a standard meal test homogeneous population adults with congenital untreated isolated GHD (IGHD) due to mutation GHRH receptor gene. In cross-sectional 20 individuals IGHD...
Individuals with congenital isolated growth hormone deficiency (IGHD) in Northeastern Brazil have a normal lifespan prolonged healthspan. We hypothesize that their increased healthspan is accompanied by reduced cognitive decline during aging. recently shown these individuals similar total function and better attention executive than controls. These data were obtained using Portuguese version of the Literacy Independent Cognitive Assessment (LICA) instrument, whose translation to facilitate...
Abstract Background The somatotrophic axis, including hypothalamic growth hormone (GH)-releasing (GHRH), pituitary GH and circulating IGF-I, is critical for body size. However, the local production of GH/IGF-I (and IGF-II) other peptides relevant functions, such as vascular, brain, retinal function. consequences deficiency (GHD) on structure are still unclear, possibly reflecting heterogeneity patients different types assessment in previous publications. Our purpose was to assess...
Objective: Catechol O-methyltransferase (COMT) is a polymorphic enzyme (val158-met: HH, HL and LL), which degrades catecholamines differentially (HH, increased activity), related to the control of food intake regulation insulin secretion. The aim present study was determine influence COMT genotypes in obesity, hypertension resistance. Design Method: We studied 149 women, with 54.05 ± 12.65 years, 63% normotensive (NT) 27% (HTA), 81.5% overweight obese (BMI>25) 18.5% normal weight. were...
Coelho, Edna; Falcao, M; Alcantara, P; Silva, A Marinho, C; Nogueira, B; Bicho, M P Author Information