A5022141225- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Esophageal Cancer Research and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Radiomics and Machine Learning in Medical Imaging
- Medical Image Segmentation Techniques
- Digital Radiography and Breast Imaging
- Lung Cancer Diagnosis and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced X-ray and CT Imaging
- Advanced Neural Network Applications
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
University of Cambridge
2025
Northwestern University
2024
Cleveland Clinic
2012-2021
Cleveland State University
2012-2013
Abstract Purpose Positron Emission Tomography (PET) scans with radioligands targeting tau neurofibrillary tangles (NFT) have accelerated our understanding of the role misfolded in neurodegeneration. While intended for human research, applying these to small animals establishes a vital translational link. Transgenic animal models dementia, such as rat SHR24, play crucial enhancing disorders. This study aims evaluate utility SHR24 model PET studies. Procedures Dynamic were conducted male rats...
To improve the accuracy of automatically segmented prostate, rectum, and bladder contours required for online adaptive therapy. The contouring on current image guidance [image guided radiation therapy (IGRT)] scan is improved by combining from earlier IGRT scans via simultaneous truth performance level estimation (STAPLE) algorithm.Six prostate patients treated with daily kilo-voltage (kV) cone-beam CT (CBCT) had their original plan nine CBCTs contoured same physician. Three types automated...
Abstract Background Measurement of Computed Tomography (CT) beam width is required by accrediting and regulating bodies for routine physics evaluations due to its direct correlation patient dose. Current methods performing CT measurement require special hardware, software, and/or consumable films. Today, most 100‐mm pencil chambers with a digital interface used evaluate Dose Index (CTDI vol ) have sufficiently high sampling rate reconstruct high‐resolution dose profile any acquisition mode....
Purpose: To characterize the dose distribution of a new multi-channel esophageal applicator for brachytherapy HDR treatment, and particularly effect presence air or water in applicator's expansion balloon. Methods: A (6) inflatable has been developed house tested simple phantom. CT image sets were obtained under several balloon expansions (80ml air, 50 cc water), channel loadings used with Oncentra (Elekta) planning system based on TG43 formalism. 400 cGy was prescribed to plane 1cm away...
Purpose: To implement and test a novel application of an online adaptive re‐planning technique, segment aperture morphing (SAM), to kV cone‐beam CT (CBCT). Methods: Five IMRT prostate patients with CBCT image guidance were chosen. The re‐planned Panther planning system (Prowess), 5 mm margin, prescribed PTV D95 76 Gy, D100 78 Gy. Daily contours generated on nine CBCTs each using ABAS (Elekta). SAM, as implemented in Panther, then executes morph apertures based changes the beams eye view...
Purpose: Dose Volume Histograms (DVH) are the main assessment of IMRT plans, yet they rely on organ contour accuracy. This study quantifies change in DVH parameters caused by systematic modification contours to replicate typical inter‐observer and auto‐contouring errors. Methods: Eight prostate patients planned for 78 Gy with margins 8 mm, (6 mm anterior posterior) were selected. Prostate uniformly expanded ±1 2 bladder 1 posterior inferior ±1, 1.5 rectum anteriorly mm. simulated contouring...
To evaluate the dosimetry of a six-channel high-dose-rate (HDR) applicator for treatment esophageal cancer with respect to lateral directionality and heterogeneous media.A computed tomography (CT)- magnetic resonance imaging (MRI)-compatible consisting 2 inflatable portions (anchor therapeutic balloons) 6 longitudinal catheters equally spaced circumferentially was constructed. Treatment plans were prepared using Oncentra 4.5 various catheter loadings target locations sizes. Calculated dose...