A5048932334- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Biosensors and Analytical Detection
- DNA and Nucleic Acid Chemistry
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Carbon and Quantum Dots Applications
- Electrochemical sensors and biosensors
- Luminescence and Fluorescent Materials
- Nanocluster Synthesis and Applications
- MicroRNA in disease regulation
- Dendrimers and Hyperbranched Polymers
- Advanced Biosensing Techniques and Applications
- Molecular Junctions and Nanostructures
- Graphene and Nanomaterials Applications
- Graphene research and applications
- Click Chemistry and Applications
- Analytical Chemistry and Sensors
- Bacteriophages and microbial interactions
- Photoacoustic and Ultrasonic Imaging
- Nanoparticle-Based Drug Delivery
- Electrochemical Analysis and Applications
- Molecular Communication and Nanonetworks
- Neuroscience and Neural Engineering
Nanjing University
2023-2025
Linyi University
2024-2025
Qingdao University
2016-2022
Qingdao Center of Resource Chemistry and New Materials
2016-2019
Liaocheng University
2015
Branched catalytic hairpin assembly is proposed for dynamic self-assembly of DNA dendrimers signal amplification and <italic>in situ</italic> imaging microRNAs in live cells with high sensitivity selectivity.
An entropy-driven catalysis (EDC) strategy is appealing for amplified bioimaging of microRNAs in living cells; yet, complex operation procedures, lacking cell selectivity, and insufficient accuracy hamper its further applications. Here, we introduce an ingenious all-in-one DNA nanomachine (termed as AIO-EDN), which can be triggered by endogenous apurinic/apyrimidinic endonuclease 1 (APE1) to achieve tumor cell-selective dual-mode imaging microRNA. Compared with the traditional EDC strategy,...
Toehold-mediated strand displacement-based nanocircuits are developed by integrating catalytic hairpin assembly with hybridization chain reaction, achieving self-assembly of hyperbranched DNA structures and amplified homogeneous CRET detection microRNA.
Abstract Small molecule‐based photothermal agents (PTAs) hold promising future for therapy; however, unexpected inactivation exerts negative impacts on their application clinically. Herein, a self‐regenerating PTA strategy is proposed by integrating 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) radical cation (ABTS •+ ) with thermodynamic agent (TDA) 2,2′‐azobis[2‐(2‐imidazolin‐2‐yl) propane] dihydrochloride (AIPH). Under NIR laser, the effect of ABTS accelerates production alkyl...
An “dual-key-and-lock” DNA nanodevice in response to cascaded endogenous stimuli of acidic pH and ATP is fabricated, achieving accurately multimodal imaging a spatio-gated manner tunable drug release for combined therapy breast cancer.
Cardiac myosin-binding protein C (cMyBP-C) is a novel cardiac marker of acute myocardial infarction (AMI) and injuries (ACI). Construction point-of-care testing techniques capable sensing cMyBP-C with high sensitivity precision urgently needed. Herein, we synthesized an Au@NGQDs@Au/Ag multi-shell nanoUrchins (MSNUs), then applied it in colorimetric/SERS dual-mode immunoassay for detection cMyBP-C. The MSNUs displayed superior stability, colorimetric brightness, SERS enhancement ability...
Chemiluminescence resonance energy transfer (CRET) DNA networks are constructed on magnetic particles initiated by target microRNA, which further functionalized with aptamers for targeted drug delivery.
Chemo-gene therapy is an emerging synergetic modality for the treatment of cancers. Herein, we developed pH-responsive multifunctional DNA nanomicelles (DNMs) as delivery vehicles controllable release doxorubicin (Dox) and anaplastic lymphoma kinase (ALK)-specific siRNA chemo-gene large cell (ALCL). Methods: DNMs were synthesized by performing in situ rolling circle amplification (RCA) on amphiphilic primer-polylactide (PLA) micelles, followed functionalization triplex via complementary base...
A versatile exonuclease-assisted target recycling amplification strategy is demonstrated to achieve label-free chemiluminescence detection of DNA and construction a series two-input molecular logic gates.
A strategy is rationally designed to finely control the hybridization chain reaction (HCR) for self-assembly of DNA nanostructures by simply changing pH, which successfully applied molecular logic operations and extracellular pH imaging.
DNA nanobrushes are constructed based on target-triggered dynamic hairpin assembly in both unidirectional and bilateral growth manners, realize sensitive selective detection of short miRNA long target DNA, respectively.