A5092494766- Microfluidic and Bio-sensing Technologies
- Cell Adhesion Molecules Research
- Physical Unclonable Functions (PUFs) and Hardware Security
- Cancer Research and Treatments
- Neuroscience and Neural Engineering
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
Universidad de Zaragoza
2023-2024
Instituto de Investigación Sanitaria Aragón
2024
In the pursuit of achieving a more realistic in vitro simulation human biological tissues, microfluidics has emerged as promising technology. Organ-on-a-chip (OoC) devices, product this technology, contain miniature tissues within microfluidic chips, aiming to closely mimic vivo environment. However, notable drawback is presence inert material between compartments, hindering complete contact tissues. Current membranes, often made PDMS or plastic materials, prevent full interaction cell types...
The main objective of this work is to assess the loosening effect blebbistatin, a specific inhibitor myosin II activity, on glioblastoma spheroids. Electric impedance will be used quantify drug, with therapeutic potential for facilitating access other treatments into tumor.
Innovative microfluidic technology aims to create more realistic in vitro simulations of human tissues. Organ-on-a-chip (OoC) devices within chips mimic vivo environments but face limitations due inert material between compartments, hindering cell interaction. Current membranes made PDMS or plastic impede proper cell-nutrient exchange and induce unexpected responses. This work focuses on minimizing materials while maximizing cell-matrix cell-cell interactions chips.
El objetivo principal de este proyecto es comprender mejor los obstáculos que encuentran las células inmunes al combatir tumores glioblastoma. Un ejemplo el alto grado compactación estos tumores, dificulta la penetración y fármacos. Este fenómeno puede revertirse con determinados compuestos, como blebistatina.