A5057136359- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Cellular Mechanics and Interactions
- Additive Manufacturing and 3D Printing Technologies
- Cancer Cells and Metastasis
- Cell Image Analysis Techniques
- Micro and Nano Robotics
- Analytical Chemistry and Sensors
- Flow Measurement and Analysis
- Computer Graphics and Visualization Techniques
- Aging and Gerontology Research
- Aluminum Alloy Microstructure Properties
- Composite Material Mechanics
- Migration, Aging, and Tourism Studies
- Fluid Dynamics Simulations and Interactions
- Cell Adhesion Molecules Research
- Retirement, Disability, and Employment
- Rheology and Fluid Dynamics Studies
- Photonic and Optical Devices
- Soil Moisture and Remote Sensing
- Adhesion, Friction, and Surface Interactions
- Advanced X-ray and CT Imaging
- Spectroscopy Techniques in Biomedical and Chemical Research
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
1970-2022
Universidad de Zaragoza
2009-2022
Instituto de Salud Carlos III
2015-2017
Universidad de Extremadura
2016
One of the main limitations for achieving truly lab-on-a-chip (LOC) devices point-of-care diagnosis is incorporation “on-chip” detection. Indeed, most state-of-the-art LOC usually require complex read-out instrumentation, losing advantages portability and simplicity. In this context, we present our last advances towards achievement a portable label-free platform with highly sensitive detection by using nanophotonic biosensors. Bimodal waveguide interferometers fabricated standard silicon...
Glioblastoma (GBM) is one of the most lethal tumor types. Hypercellular regions, named pseudopalisades, are characteristic in these tumors and have been hypothesized to be waves migrating glioblastoma cells. These "waves" cells thought induced by oxygen nutrient depletion caused tumor-induced blood vessel occlusion. Although universal presence structures GBM suggests that they may play an instrumental role GBM's spread invasion, recreation vitro has remained challenging.
Organ-on-chip (OOC) technology has recently emerged as a powerful tool to mimic physiological or pathophysiological conditions through cell culture in microfluidic devices. One of its main goals is bypassing animal testing and encouraging more personalized medicine. The recent incorporation hydrogels 3D scaffolds into devices changed biomedical research since they provide biomimetic extracellular matrix recreate tissue architectures. However, this presents some drawbacks such the necessity...
Abstract The immune system plays a crucial role in shaping the glioblastoma tumor microenvironment, characterized by its complexity and dynamic interactions. Understanding tumor‐immune crosstalk is essential for advancing cancer research therapeutic development. Here, novel multicompartment, barrier‐free microfluidic device presented that overcomes limitations of existing models enabling direct interactions without physical barriers, preserving natural cell infiltration. This platform...
Journal Article Paired-Associate Learning as a Function of Adult Age and the Length Anticipation Inspection Intervals Get access Rolf H. Monge, Ph.D., Ph.D. 2Rolf Development Study, 910 Irving Ave.,Syracuse, 13210 Search for other works by this author on: Oxford Academic PubMed Google Scholar David F. Hultsch, 3Pennsylvania State UniversityUniversity Park, 16802. Gerontology, Volume 26, Issue 2, April 1971, Pages 157–162, https://doi.org/10.1093/geronj/26.2.157 Published: 01 1971
The tumour microenvironment is very complex, and essential in development drug resistance. endothelium critical the microenvironment: it provides nutrients oxygen to for systemic delivery. Therefore, we report a simple, user-friendly microfluidic device co-culture of 3D breast model 2D cross-talk delivery studies. First, demonstrated was functional, whereas exhibited vivo features, e.g., gradients preferential proliferation cells with better access oxygen. Next, observed structure lost its...
We report the first application of a microfluidic device to observe chemotactic migration in multicellular spheroids. A was designed comprising central microchamber and two lateral channels through which reagents can be introduced. Multicellular spheroids were embedded collagen introduced microchamber. gradient fetal bovine serum (FBS) established across chamber by addition growth media containing into one channels. that oral squamous carcinoma cells OSC-19 invade collectively direction FBS....
Tissues are complex three-dimensional structures in which cell behaviour is frequently guided by chemotactic signals. Although starvation and nutrient restriction induce many different processes, the recreation of such conditions vitro remains difficult when using standard culture equipment. Recently, microfluidic techniques have arisen as powerful tools to mimic physiological conditions. In this context, systems require precise control cell/hydrogel location because samples need be placed...
The use of blood samples as liquid biopsy is a label-free method for cancer diagnosis that offers benefits over traditional invasive techniques. Cell sorting by acoustic waves means to separate rare cells from based on their physical properties in label-free, contactless and biocompatible manner. Herein, we describe flow-through separation approach provides an efficient tumor (TCs) white (WBCs) microfluidic device, "THINUS-Chip" (Thin-Ultrasonic-Separator-Chip), actuated ultrasounds. We...
Study explores COP-based microfluidic device surface modifications to maintain 3D cell culture, prevent hydrogel detachment and enable more accurate in vitro models mimicking tumour microenvironment ischaemia.
A new microfluidic cell culture device compatible with real-time nuclear magnetic resonance (NMR) is presented here. The intended application the long-term monitoring of 3D cultures by several techniques. system has been designed to fit inside commercially available NMR equipment obtain maximum readout resolution when working small samples. Moreover, integrates a fibre-optic-based sensor monitor parameters such as oxygen, pH, or temperature during monitoring, and it also allows use optical...
Abstract Glioblastoma (GBM), also named grade IV astrocytoma, is the most common and lethal malignant primary brain tumor. GBM characterized by two main histopathological conditions: necrotic foci typically surrounded areas of high cellularity microvascular proliferation. The causes such densely populated regions, known a “pseudopalisades”, remain poorly understood. Firstly, was thought to be due rapid proliferation cells, however recent histological studies have shown that in...
In the pursuit of achieving a more realistic in vitro simulation human biological tissues, microfluidics has emerged as promising technology. Organ-on-a-chip (OoC) devices, product this technology, contain miniature tissues within microfluidic chips, aiming to closely mimic vivo environment. However, notable drawback is presence inert material between compartments, hindering complete contact tissues. Current membranes, often made PDMS or plastic materials, prevent full interaction cell types...
Innovative microfluidic technology aims to create more realistic in vitro simulations of human tissues. Organ-on-a-chip (OoC) devices within chips mimic vivo environments but face limitations due inert material between compartments, hindering cell interaction. Current membranes made PDMS or plastic impede proper cell-nutrient exchange and induce unexpected responses. This work focuses on minimizing materials while maximizing cell-matrix cell-cell interactions chips.
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Survey of Gerontologists' Opinions on White House Conference Aging Issues Education and Training William Hawlcinson, PhD, PhD Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Percil Stanford, Rolf Monge, David Dowd, MS The Gerontologist, Volume 12, Issue 1_Part_1, Spring 1972, Pages 79–84, https://doi.org/10.1093/geront/12.1_Part_1.79 Published: 01 March 1972