A5054569884- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nanoparticle-Based Drug Delivery
- Phytochemicals and Antioxidant Activities
- Crystallography and molecular interactions
- Free Radicals and Antioxidants
- Ferrocene Chemistry and Applications
- Plant-Derived Bioactive Compounds
- Dendrimers and Hyperbranched Polymers
- Antioxidant Activity and Oxidative Stress
- Estrogen and related hormone effects
- Microencapsulation and Drying Processes
- Nanocluster Synthesis and Applications
- Genetic factors in colorectal cancer
- Barrier Structure and Function Studies
- Synthesis and Biological Evaluation
- Cynara cardunculus studies
- Medicinal plant effects and applications
- Curcumin's Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Pomegranate: compositions and health benefits
- Microwave-Assisted Synthesis and Applications
- Computational Drug Discovery Methods
- Protease and Inhibitor Mechanisms
Instituto de Investigación Sanitaria Aragón
2017-2025
Universidad de Zaragoza
2016-2024
Instituto de Síntesis Química y Catálisis Homogénea
2019-2022
Artichoke waste represents a huge amount of discarded material. This study presents the by-products (bracts, exterior leaves, and stalks) “Blanca de Tudela” artichoke variety as potential source phenolic compounds with promising antioxidant properties. residues were subjected to different extraction processes, capacity composition extracts analyzed by spectrophotometric methods high performance liquid chromatography (HPLC) analyses, respectively. The most abundant polyphenols in chlorogenic...
Abstract Immunotherapy remains more effective for hematologic tumors than solid tumors. One of the main challenges to immunotherapy is immunosuppressive microenvironment these generate, which limits cytotoxic capabilities immune effector cells (e.g., T and natural killer cells). This characterized by hypoxia, nutrient starvation, accumulated waste products, acidic pH. Tumor-hijacked cells, such as fibroblasts, macrophages, regulatory also contribute this inhospitable secreting cytokines that...
Sphingomyelin Nanoemulsions (SNs) are promising drug delivery systems with potential for treating challenging tumors, including Non-Small Cell Lung Cancer (NSCLC), which has poor prognosis and a 5-year survival rate below 5%. Understanding the toxicity mechanisms intracellular behavior of SNs is crucial optimizing their therapeutic application. This study aims to investigate interaction between A549 lung adenocarcinoma cells, focusing on cytotoxic effects cellular toxicity. were synthesized...
Sphingomyelin nanoemulsions (SNs) are promising drug delivery systems with potential for treating challenging tumors, including non-small cell lung cancer (NSCLC), which has a poor prognosis and 5-year survival rate below 5%. Understanding the toxicity mechanisms intracellular behavior of SNs is crucial optimizing their therapeutic application. This study aims to investigate interaction between A549 adenocarcinoma cells, focusing on cytotoxic effects cellular toxicity. were synthesized...
New mixed gold(III) derivatives with dithiocarbamate and thiolate ligands have been synthesized characterized. They display high anticancer activity against colon cancer cell lines without affecting to differentiated enterocytes, stability in phosphate-buffered saline solution, resistance gold reduction the presence of reducing agents majority derivatives. Some them show interaction thioredoxin reductase as derived from vitro analysis computational studies. However, a competition between...
Given the alarming increase in colorectal cancer (CRC) worldwide, novel therapies are urgently needed. Plant-derived extracts have gained considerable interest last years due to their strong anticancer effect mediated by unique bioactive compounds. Specifically, rosehips from Rosa canina been successfully tested against several models, including colon cancer. Moreover, gold derivatives a promising alternative current platinum-based drugs commonly used CRC chemotherapy lack of affinity for...
A series of gold(I) and silver(I) derivatives with N- or S-donor ligands derived from 2-anilinopyridine has been synthesized characterized. The mononuclear structure [Au(L1)(PPh3)](TfO) (1a) [Au(L2)(PPh3)](TfO) (1b) was confirmed by X-ray diffraction studies, as well the dinuclear in case [Ag(TfO)(L1)]2 (4a). Most complexes are cytotoxic against a model colorectal adenocarcinoma (Caco-2 cell line) breast cancer lines (MCF-7). able to induce caspases 8 3 activation, loss mitochondrial...
In this paper we describe the synthesis of new N-heterocyclic carbene (NHC) gold(I) derivatives with flavone-derived ligands a propargyl ether group. The compounds were screened for their antimicrobial and anticancer activities, showing greater activity against bacteria than colon cancer cells (Caco-2). Complexes [Au(L2b)(IMe)] (1b) [Au(L2b)(IPr)] (2b) found to be active both Gram-positive Gram-negative strains. mechanism action 1b was evaluated by measurement thioredoxin reductase (TrxR)...
Squalene, a triterpene found in extra virgin olive oil, has therapeutic properties diseases related to oxidative stress, such as cancer. However, its hydrophobic nature and susceptibility oxidation limit bioavailability outside of oil. To expand applications, alternative delivery methods are necessary. The objective the present study was examine impact squalene encapsulated PLGA (poly(lactic-co-glycolic) acid) nanoparticles (PLGA + Sq) on proliferation human colon carcinoma Caco-2 cells,...
The socioeconomic, cultural, therapeutic, and nutritional potential of Amazonian fruits has been limited due to the scarce information about its phytochemical profile.The aim this study was determine total phenolic content profiles by Folin colorimetric miniaturized assay, identification compounds UHPLC-HRMS, antioxidant capacity DPPH, ABTS, NBT assays, as well as, antiproliferative activity sulforhodamine B assay extracts obtained from ten native Amazon region, some these consumed...
This work aims to develop an in vitro three-dimensional model of triple negative breast cancer study the influence tumor microenvironment on treatment response and cell invasion. The was exposed chemotherapeutic agents different responses were observed when cells cultured 2D or 3D.
Maritime pine bark (Pinus pinaster Aiton subsp. atlantica) is rich in polyphenols with known bioactive properties which are beneficial for human health. However, biological activities of extracts depend on the type extracted and characteristics these extractives several factors such as solvents used. The influence extraction solvent composition consequently has been poorly described. Thus, this study (water, ethanol ethanol-water (50/50 v/v%)) antibacterial anticancer P. samples were...