A5074079567- Alzheimer's disease research and treatments
- Neuroscience and Neural Engineering
- Barrier Structure and Function Studies
- 3D Printing in Biomedical Research
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Graphene and Nanomaterials Applications
- Micro and Nano Robotics
- Microfluidic and Bio-sensing Technologies
- Extracellular vesicles in disease
- Neurological disorders and treatments
- Nanoplatforms for cancer theranostics
- Cell Adhesion Molecules Research
- Surfactants and Colloidal Systems
- Nanoparticles: synthesis and applications
Institute for Bioengineering of Catalonia
2022-2024
Universitat de Barcelona
2022-2024
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2023
Instituto de Salud Carlos III
2023
Creative Commons
2023
Institute of Science and Technology
2023
University of Chile
2020-2022
Advanced Center for Chronic Diseases
2015
The lack of predictive models that mimic the blood-brain barrier (BBB) hinders development effective drugs for neurodegenerative diseases. Animal behave differently from humans, are expensive and have ethical constraints. Organ-on-a-chip (OoC) platforms offer several advantages to resembling physiological pathological conditions in a versatile, reproducible, animal-free manner. In addition, OoC give us possibility incorporate sensors determine cell culture features such as trans-endothelial...
Extracellular vesicles (EVs) have shown great potential for targeted therapy, as they a natural ability to pass through biological barriers and, depending on their origin, can preferentially accumulate at defined sites, including tumors. Analyzing the of EVs target specific cells remains challenging, considering unspecific binding lipophilic tracers other proteins, limitations fluorescence deep tissue imaging and effect external labeling strategies tropism. In this work, we determined...
A hydroxycinnamic acid derivative, namely ferulic (FA) has been successfully encapsulated in polymeric nanoparticles (NPs) based on poly(lactic-co-glycolic acid) (PLGA). FA-loaded NPs were prepared from O/W nano-emulsion templates using the phase inversion composition (PIC) low-energy emulsification method. The obtained PLGA exhibited high colloidal stability, good drug-loading capacity, and particle hydrodynamic diameters range of 74 to 117 nm, depending FA concentration used. In vitro drug...
Organ-on-chip (OOC) technology has recently emerged as a powerful tool to mimic physiological or pathophysiological conditions through cell culture in microfluidic devices. One of its main goals is bypassing animal testing and encouraging more personalized medicine. The recent incorporation hydrogels 3D scaffolds into devices changed biomedical research since they provide biomimetic extracellular matrix recreate tissue architectures. However, this presents some drawbacks such the necessity...
Current strategies for brain diseases are mostly symptomatic and noncurative. Nanotechnology has the potential to facilitate transport of drugs across blood–brain barrier enhance their pharmacokinetic profile. However, reach clinical application, an understanding nanoneurotoxicity in terms oxidative stress inflammation is required. Emerging evidence also shown that nanoparticles have ability alter autophagy, which can induce stress, or vice versa. These effects may increase neurodegenerative...
Alzheimer's disease is characterized by a combination of several neuropathological hallmarks, such as extracellular aggregates beta amyloid (Aβ). Numerous alternatives have been studied for inhibiting Aβ aggregation but, at this time, there are no effective treatments available. Here, we developed the tri-component nanohybrid system AuNPs@POM@PEG based on gold nanoparticles (AuNPs) covered with polyoxometalates (POMs) and polyethylene glycol (PEG). In work, demonstrated inhibition formation...
Abstract Alzheimer’s disease is characterized by the combination of several neuropathological hallmarks such as extracellular aggregates beta amyloid (Aβ). Numerous alternatives have been studied for inhibiting Aβ aggregation but at this moment there are no effective treatments available. Here, we developed tri-component nanohybrid system AuNPs@POM@PEG, based on gold nanoparticles (AuNPs) covered with polyoxometalates (POMs) and polyethylene glycol (PEG). In work, AuNPs@POM@PEG demonstrated...
ABSTRACT Background The lack of predictive models that mimic the blood-brain barrier (BBB) hinders development effective drugs for neurodegenerative diseases. Animal behave differently from humans, are expensive and have ethical constraints. Organ-on-a-chip (OoC) platforms offer several advantages to resembling physiological pathological conditions in a versatile, reproducible, animal-free manner. In addition, OoC give us possibility incorporate sensors determine cell culture features such...
Nanobioengineering Group, Institute for Bioengineering of Catalonia (IBEC) Barcelona Science and Technology (BIST), Barcelona, Spain (Palma-Florez S, Lagunas A, Mir M) CIBER-BBN, ISCIII, Madrid, (Lagunas Department Electronics Biomedical Engineering, University *Correspondence to: Mònica Mir, PhD, [email protected]. #Both authors contributed equally to this article. This is an open-access article distributed under the terms Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported,...
Abstract Background The lack of predictive models that mimic the blood-brain barrier (BBB) hinders development effective drugs for neurodegenerative diseases. Animal behave differently from humans, are expensive and have ethical constraints. Organ-on-a-chip (OoC) platforms offer several advantages to resembling physiological pathological conditions in a versatile, reproducible, animal-free manner. In addition, OoC give us possibility incorporate sensors determine cell culture features such...