A5114919234- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Plant Gene Expression Analysis
- Genetics and Neurodevelopmental Disorders
Rutgers, The State University of New Jersey
2025
Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances altered synaptic function. Cul3 engages dozens adaptor proteins to recruit hundreds substrates for ubiquitination, but adaptors that impact synapses remain ill-defined. Here we implicate Insomniac (Inc), a conserved protein required normal homeostasis in Drosophila , as adaptor. Inc binds vivo, mutations within N-terminal BTB domain...
Abstract Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances altered synaptic function. Cul3 engages dozens adaptor proteins to recruit hundreds substrates for ubiquitination, but adaptors that impact synapses remain ill-defined. Here we implicate Insomniac (Inc), a conserved protein required normal homeostasis in Drosophila , as adaptor. Inc binds vivo, mutations within N-terminal BTB...