A5071124328- Neuropeptides and Animal Physiology
- Autophagy in Disease and Therapy
- Neuroendocrine regulation and behavior
- Ubiquitin and proteasome pathways
- Schizophrenia research and treatment
- Neurobiology and Insect Physiology Research
- Mental Health Research Topics
- Mental Health and Psychiatry
- Human-Animal Interaction Studies
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Mental Health Treatment and Access
- Sleep and related disorders
- Insect and Arachnid Ecology and Behavior
- Child and Adolescent Psychosocial and Emotional Development
- Resilience and Mental Health
- Olfactory and Sensory Function Studies
- Plant Molecular Biology Research
- Sleep and Wakefulness Research
- Plant Gene Expression Analysis
New York University
2018-2025
University of California, Los Angeles
2023-2025
Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances altered synaptic function. Cul3 engages dozens adaptor proteins to recruit hundreds substrates for ubiquitination, but adaptors that impact synapses remain ill-defined. Here we implicate Insomniac (Inc), a conserved protein required normal homeostasis in Drosophila , as adaptor. Inc binds vivo, mutations within N-terminal BTB domain...
Abstract Early life trauma is a risk factor for life‐long disorders related to emotional processing, but knowledge underlying its enduring effect incomplete. This study was motivated by the hypothesis that early increases amygdala‐dependent threat responses via reduction in inhibition parvalbumin (PV) interneurons and perineuronal nets (PNN) supporting PV cells, thus increasing excitability of basolateral amygdala (BLA). From postnatal day (PN) 8–12, rat pups both sexes were reared under...
Individuals at clinical high risk for psychosis (CHR) report a strong desire psychoeducation, and guidelines recommend psychoeducation in early care. Although several CHR models have been developed, additional research is needed to establish the effectiveness of these models. The goal this study was conduct pilot trial Brief Educational Guide Need (BEGIN). BEGIN brief structured intervention designed educate individuals on symptoms treatment options. We conducted feasibility 25 (60% female,
Although many genes are known to influence sleep, when and how they impact sleep-regulatory circuits remain ill-defined. Here, we show that insomniac ( inc ), a conserved adaptor for the autism-associated Cul3 ubiquitin ligase, acts in restricted period of neuronal development sleep adult Drosophila . The loss causes structural functional alterations within mushroom body (MB), center sensory integration, associative learning, regulation. In mutants, MB neurons produced excess, develop...
Abstract Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances altered synaptic function. Cul3 engages dozens adaptor proteins to recruit hundreds substrates for ubiquitination, but adaptors that impact synapses remain ill-defined. Here we implicate Insomniac (Inc), a conserved protein required normal homeostasis in Drosophila , as adaptor. Inc binds vivo, mutations within N-terminal BTB...