A5040225611- Mitochondrial Function and Pathology
- Infective Endocarditis Diagnosis and Management
- RNA and protein synthesis mechanisms
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects and Toxicity Studies
- Pneumonia and Respiratory Infections
- Genomics and Rare Diseases
- Cancer-related Molecular Pathways
- ATP Synthase and ATPases Research
- Drug Transport and Resistance Mechanisms
- Photosynthetic Processes and Mechanisms
- Nanoparticle-Based Drug Delivery
- PI3K/AKT/mTOR signaling in cancer
National Taiwan University
2022-2023
University of Illinois Chicago
2001
ABSTRACT Natural genetic transformation offers a direct route by which synthetic gene constructs can be placed into the single circular chromosome of Streptococcus pneumoniae . However, lack general negative-selection marker has hampered introduction that do not confer selectable phenotype. A 1.3-kb cassette was constructed comprising kanamycin (Kn) resistance ( kan ) and counterselectable rpsL + marker. The conferred dominant streptomycin (Sm) sensitivity in an Sm-resistant background S. It...
Mitochondria are dynamic organelles regulated by fission and fusion processes. The of membranes requires elaborative coordination proteins lipids is particularly crucial for the function quality control mitochondria. Phosphatidic acid (PA) on mitochondrial outer membrane generated PLD6 facilitates However, how PA promotes remains unclear. Here, we show that a protein, NME3, required PLD6-induced tethering or clustering. NME3 enriched at contact interface two closely positioned mitochondria...
Breast cancer is the most prevalent and second leading cause of death in women. Cisplatin a commonly used chemotherapeutic drug for breast treatment. Owing to serious side effects, combination cisplatin with other drugs an effective strategy simultaneously reduce effects increase anticancer efficacy. GLUT1 emerging target treatment since cells usually consume more glucose, phenomenon called Warburg effect. In this study, we found that novel inhibitor #43 identified from our previous...
Abstract Background Rare mutations in NADH:ubiquinone oxidoreductase complex assembly factor 5 ( NDUFAF5 ) are linked to Leigh syndrome. Objective We aimed describe clinical characteristics and functional findings a patient cohort with mutations. Methods Patients biallelic were recruited from multi‐centers Taiwan. Clinical, laboratory, radiological, follow‐up features recorded mitochondrial assays performed patients' skin fibroblasts. Results Nine patients seven unrelated pedigrees enrolled,...
Cancer drug resistance is an ever-changing problem that most patients need to face in their later stages of treatment, especially the multidrug resistant (MDR) type. The efflux transporters, including P-glycoprotein (P-gp), protein 1 (MRP1), and breast cancer (BCRP), play crucial roles this sophisticated battle. In recent decades, researchers try find potential inhibitors impede function above transporters. d-α-Tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS) a prevalently used...