A5018629557- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Cystic Fibrosis Research Advances
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Parathyroid Disorders and Treatments
- Energy Harvesting in Wireless Networks
- Reconstructive Surgery and Microvascular Techniques
- Pluripotent Stem Cells Research
- Periodontal Regeneration and Treatments
- Tracheal and airway disorders
- Connexins and lens biology
- Electrospun Nanofibers in Biomedical Applications
- Renal and related cancers
- IgG4-Related and Inflammatory Diseases
- Neuroscience of respiration and sleep
- Soft tissue tumor case studies
University of Molise
2017-2022
University of Foggia
2016-2022
Karolinska Institutet
2016
Transfusion (or drinking) of blood or its components has been thought as a rejuvenation method since ancient times. Parabiosis, the procedure joining two animals so that they share each others circulation, revitalized concept putative drug. Since 2005, number papers have reported anti-ageing effect heterochronic parabiosis, which is an aged mouse to young partner. The hallmark aging decline regenerative properties in most tissues, partially attributed impaired function stem and progenitor...
On behalf of SIFC working group for the revision Consensus document about genetic analysis in cystic fibrosis.pathogen detection, point-of-care (POC) testing and clinical isolate identification with MALDI-TOF MS.Despite advent cutting edge molecular-based (real time PCR, 16S rRNA sequencing, next-generation sequencing) protein-based microbial tools, there is an enormous need to continue culture-based assess susceptibility all antimicrobials identify pathogens mutations that may escape...
We previously found that human amniotic mesenchymal stem cells (hAMSCs) in coculture with CF immortalised airway epithelial (CFBE41o- line, CFBE) on Transwell® filters acquired an phenotype and led to the expression of a mature functional CFTR protein. In order explore role gap junction- (GJ-) mediated intercellular communication (GJIC) this rescue, cocultures (hAMSC : CFBE, 1 5 ratio) were studied for formation GJIC, before after silencing connexin 43 (Cx43), major component GJs. Functional...
In the context of biointeractive dressings used for enhancing wound healing, use stromal vascular fraction (SVF) or adipose-derived stem cells (ASCs) hereof derived has not been fully exploited yet. Noncultured SVF, a heterogeneous mesenchymal population cells, is attractive in field dermal regeneration because it can be instantaneously obtained, avoids genomic alterations, and comparatively safer than cultured ASCs. Integra® Dermal Regeneration Template (DRT) was sprinkled with ASCs...
Cystic fibrosis (CF) airways are affected by a deranged repair of the damaged epithelium resulting in altered regeneration and differentiation. Previously, we showed that human amniotic mesenchymal stem cells (hAMSCs) corrected base defects CF airway epithelial via connexin (CX)43-intercellular gap junction formation. In this scenario, it is unknown whether hAMSCs, or fibroblasts sharing some common characteristics with MSCs, can operate faster epithelium. A tip-based scratch assay was...
Human amnion-derived mesenchymal stromal cells (hAMSCs) are used increasingly in regenerative medicine applications, including dentistry. The aim of this study was to evaluate if hAMSCs from aged and pathological mothers could be affected their phenotype functional behavior. were isolated placentas women younger than 40 years (Group 1, n = 7), older 2, 6), with pre-eclampsia 3, 5). Cell yield viability assessed at isolation (p0). proliferation evaluated p0 p5. Passage 2 determine the...
Introduction: Cystic fibrosis (CF) is the most fatal autosomal recessive disorder caused by absence/dysfunction of CF transmembrane conductance regulator (CFTR) protein at apical membrane epithelial cells. The variety innovative drug- and gene-based approaches warrants development assays that can allow disease modeling high-throughput screening drugs.Areas covered: This article aims to highlight role stem cells in models recapitulate pathophysiology lungs, pancreas, liver, gut. Particular...