A5065700548- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- COVID-19 Clinical Research Studies
- Urinary and Genital Oncology Studies
- Cell death mechanisms and regulation
- Oral Health Pathology and Treatment
- Ovarian cancer diagnosis and treatment
- Advanced Proteomics Techniques and Applications
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Cervical Cancer and HPV Research
- Fibroblast Growth Factor Research
- Uterine Myomas and Treatments
- Hippo pathway signaling and YAP/TAZ
- Liver physiology and pathology
- Respiratory Support and Mechanisms
- Inflammasome and immune disorders
- Nitrogen and Sulfur Effects on Brassica
- Estrogen and related hormone effects
- COVID-19 and healthcare impacts
- COVID-19 Impact on Reproduction
- Muscle Physiology and Disorders
University of Foggia
2014-2025
Abstract Background Recent emerging evidences identify Human Papillomavirus (HPV) related Head and Neck squamous cell carcinomas (HN-SCCs) as a separate subgroup among Cancers with different epidemiology, histopathological characteristics, therapeutic response to chemo-radiation treatment clinical outcome. However, there is not worldwide consensus on the methods be used in practice. The endpoint of this study was demonstrate reliability triple method which combines evaluation of: 1. p16...
Deregulated expression of inhibitors apoptosis may contribute to cancer by aberrantly extending cell viability and facilitating the insurgence resistance chemo- radiotherapy. In this study, we have investigated, immunohistochemical technique, potential prognostic significance survivin in a series 49 clear type renal carcinoma (ccRCC). Survivin was significantly associated with poorly differentiated, advanced stages more aggressive ccRCCs (p < 0.05). Patients low had statistically significant...
Recent studies have shown that production of cortisol not only takes place in several non-adrenal peripheral tissues such as epithelial cells but, also, the local inter-conversion between cortisone and is regulated by 11β-hydroxysteroid dehydrogenases (11β-HSDs). However, little known about activity this glucocorticoid system cancers.The presence a functioning was assessed human skin squamous cell carcinoma (SCC) melanoma further, 16 lines from 8 different tissue types using ELISA, western...
To the current data, there have been 6,955,141 COVID-19-related deaths worldwide, reported to WHO. Toll-like receptors (TLRs) implicated in bacterial and virus sensing could be a crosstalk between activation of persistent innate-immune inflammation, macrophage's sub-population alterations, cytokine storm, macrophage over-activation syndrome, unresolved Acute Respiratory Disease Syndrome (ARDS), death. The aim this study is demonstrate association Toll-like-receptor-4 (TLR-4)-induced...
Survivin is a well-known protein involved in the inhibition of apoptosis many different cancer types. The aim this study was to perform an integrated bioinformatic and histologic analysis order expression prognostic role its related gene BIRC5 oral cancer. Publicly available databases were accessed via Gene Expression Omnibus Oncomine, addition raw data from Cancer Genome Atlas (TCGA) also obtained analyze rate mutation, methylation patients with squamous cells carcinoma (OSCC)....
// Luigi Cormio 1, * , Francesca Sanguedolce 2, Antonella 3 Paolo Massenio 1 Maria Carmela Pedicillo 2 Simona Cagiano Giuseppe Calò Vincenzo Pagliarulo 4 Carrieri ** Pantaleo Bufo Department of Urology, University Hospital Foggia, Italy Pathology, Biosciences, Biotechnologies, and Biopharmaceutics, Bari, These authors have contributed equally to this work share senior authorship Correspondence to: Sanguedolce, email: fradolce@hotmail.com Keywords: non-muscle-invasive bladder cancer, HER-2,...
Saliva is one of the most promising and easy-to-collect source potential biomarkers oral systemic disease. We standardized a protocol suitable for pre-analytical treatment analysis whole normal saliva by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF/MS).We evaluated impact storage time, freeze/thaw cycles, denaturing agents, glycoproteins depletion, centrifugation, type matrix ProteinChip used on quality SELDI protein profile. Moreover, we explored...
Abstract The stem cell ability to self-renew and lead regeneration relies on the balance of complex signals in their microenvironment. identification modulators hepatic progenitor (HPC) activation is determinant for liver may improve transplantation end-stage disease. This investigation used different models point out Nuclear factor (erythroid-derived 2)-like 2 (NRF2) as a key regulator HPC fate. We initially proved that vivo biliary epithelial cells (BECs)/HPC show oxidative stress, which...
Survivin is a recently described inhibitor of apoptosis and mitotic regulator which selectively over-expressed in human tumors. Its expression rate predictive disease progression, early recurrences resistance to therapy. Up-regulation survivin oral pre-malignant lesions (OPL) squamous cell carcinoma (OSCC) has already been demonstrated previous studies. A critical step for activation identified the phosphorylation on Thr34 by main kinase p34cdc2-cyclin B1. The aim this work was investigate...
Musashi 2 (MSI2), which is an RNA-binding protein, plays a fundamental role in the oncogenesis of several cancers. The aim this study to investigate expression MSI2 Oral Squamous Cell Carcinoma (OSCC) and evaluate its correlation clinic-pathological variables prognosis.A bioinformatic analysis was performed on data downloaded from Cancer Genome Atlas (TCGA) database. were analysed for their with prognostic features. In addition, immmunohistochemical evaluation 108 OSCC samples included...
Recent emerging evidences identify Human Papillomavirus (HPV) related Head and Neck squamous cell carcinomas (HN-SCCs) as a separate subgroup among Cancers with different epidemiology, histopathological characteristics, therapeutic response to chemo-radiation treatment clinical outcome. However, there is not worldwide consensus on the methods be used in practice. The endpoint of this study was demonstrate reliability triple method which combines evaluation of: 1. p16 protein expression by...
Inflammatory microenvironment is an essential component of all tumors, including thyroid cancer. Autoimmune diseases are often associated with CD25, expressed in Treg cells and B cells, has been found to be autoimmune the NFkB pathway critical tumor formation, regulating immune-related genes, pro-inflammatory cytokine.Protein expression CD25 its phosphorylated form was analyzed by immunohistochemistry 80 patients cancer (10 cases cancers Hashimoto's thyroiditis 70 without).CD25 mainly...
Abstract Background ADAR 1 is an enzymatic protein, which catalyzes a RNA editing reaction by converting Adenosine to Inosine, and its expression has been found be dysregulated in many cancer types. The aim of this study was analyze the oral squamous cells carcinoma. Methods In order mRNA expression, data from Cancer Genome Atlas ( TCGA ) database were downloaded analyzed. addition, immunohistochemistry analysis performed on institutional including 46 samples cell carcinoma tissue microarray...
In the context of biointeractive dressings used for enhancing wound healing, use stromal vascular fraction (SVF) or adipose-derived stem cells (ASCs) hereof derived has not been fully exploited yet. Noncultured SVF, a heterogeneous mesenchymal population cells, is attractive in field dermal regeneration because it can be instantaneously obtained, avoids genomic alterations, and comparatively safer than cultured ASCs. Integra® Dermal Regeneration Template (DRT) was sprinkled with ASCs...
Background: HPV-positive oral squamous cell carcinomas (OSCCs) are specific biological and clinical entities, characterized by a more favorable prognosis compared to HPV-negative OSCCs occurring generally in non-smoking non-drinking younger individuals. However, poor information is available on the molecular behavior of cancers smoking/drinking subjects. Thus, this study was designed compare, at level, two OSCC lines, both derived from drinking smoking individuals differing for...
High-risk HPVs (HR-HPVs) are DNA viruses considered as primary etiologic factors in malignancies of the low female genital tract. Their presence has also been documented oropharyngeal and laryngeal cancers. However, HPV infection is a necessary but not sufficient cause tumoral development; meantime, increasing evidences on tumorigenic role cancer stem cells (CSCs) have literature. CSCs represent small subpopulation neoplastic with self-renewal potential, capable maintaining tumor growth cell...
Toll-like receptors (TLRs) regulate innate and adaptive immune responses. Moreover, TLRs can induce a pro-survival pro-proliferation response in tumor cells. This study aims to investigate the expression of TLR4 epithelium surrounding oral squamous cell carcinomas (OSCC) relation its inflammatory microenvironment. included 150 human samples: 30 normal control (NOC), 38 non-lichenoid OSCC (NLE-OSCC), 28 lichenoid (LE-OSCC), ex-non lesion (OSCC Ex-NOLL), 24 ex-oral Ex-OLL). was investigated by...