A5081297507- BRCA gene mutations in cancer
- Male Breast Health Studies
- Genomic variations and chromosomal abnormalities
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Diet, Metabolism, and Disease
- Health disparities and outcomes
- Cholesterol and Lipid Metabolism
- Genomics, phytochemicals, and oxidative stress
- Health, psychology, and well-being
- Electromagnetic Fields and Biological Effects
- FOXO transcription factor regulation
- Nutrition, Genetics, and Disease
- Liver physiology and pathology
- Congenital heart defects research
- Long-Term Effects of COVID-19
- Mycobacterium research and diagnosis
- Helicobacter pylori-related gastroenterology studies
- Genetics, Aging, and Longevity in Model Organisms
- Cancer therapeutics and mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Gene expression and cancer classification
- Pneumonia and Respiratory Infections
- Virology and Viral Diseases
- Biomedical Text Mining and Ontologies
University of Foggia
2013-2024
Ospedali Riuniti di Foggia
2020-2022
Istituto Tumori Bari
2010-2011
Vrije Universiteit Amsterdam
2011
Istituto Dermopatico dell'Immacolata
2009
Sustainable Development Goals (SDGs) and 2030 Agenda represent global development programs. Education can widen the acknowledgement of their relevance applications. This survey aims to assess awareness, knowledge attitudes towards SDGs sustainability among first-year students in nine Italian Universities. A Likert scale-based online questionnaire 70 items was compiled by from March July 2019. It examined expectations referred sustainable concepts, indicators documents/models accounting for...
A disruption to circadian rhythmicity and the sleep/wake cycle constitutes a major feature of Alzheimer's disease (AD). The maintenance is regulated by endogenous clock genes number external Zeitgebers, including light. This study investigated light induced changes in expression triple transgenic model AD (3×Tg-AD) their wild type littermates (Non-Tg). Changes gene were evaluated four brain areas¾suprachiasmatic nucleus (SCN), hippocampus, frontal cortex brainstem¾of 6- 18-month-old Non-Tg...
The complete mechanism accounting for the progression from simple steatosis to steatohepatitis in nonalcoholic fatty liver disease (NAFLD) has not been elucidated. Lipotoxicity refers cellular injury caused by hepatic free acids (FFAs) and cholesterol accumulation. Excess autoxidizes oxysterols during oxidative stress conditions. We hypothesize that interaction of FAs derivatives may primarily impair mitochondrial function affect biogenesis adaptation NAFLD progression. demonstrated...
Abstract Background From the initial stages of pandemic in early 2020, COVID-19-related olfactory and gustatory dysfunctions have been widely reported are emerging as one most frequent long-term sequelae SARS-CoV-2 infection. However, data regarding recovery sense smell taste lacking. This study aimed to characterize evolution up year after diagnosis self-reported COVID-19 cases. Methods Based on active surveillance platform Apulia region, Italy, we selected residents Foggia district who...
Priorix-Tetra™ (MMRV GlaxoSmithKline Biologicals' vaccine) was developed based on the existing measles-mumps-rubella and varicella vaccines. In this study, we aimed to estimate effectiveness of combined measles-mumps-rubella-varicella vaccine against in real-world conditions. We conducted a post-marketing retrospective case-control study Apulia region Italy children aged 1-9 years born between January 1, 2008 December 31, 2016. assessed all grades severity (including hospitalisation)...
Abstract The stem cell ability to self-renew and lead regeneration relies on the balance of complex signals in their microenvironment. identification modulators hepatic progenitor (HPC) activation is determinant for liver may improve transplantation end-stage disease. This investigation used different models point out Nuclear factor (erythroid-derived 2)-like 2 (NRF2) as a key regulator HPC fate. We initially proved that vivo biliary epithelial cells (BECs)/HPC show oxidative stress, which...
Background : Male breast cancer (MBC) is a rare disease and little known about its etiopathogenesis. Array comparative genomic hybridization (aCGH) provides method to quantitatively measure the changes of DNA copy number map them directly onto complete linear genome sequences. The aim this study was investigate imbalances by aCGH compare with female dataset. Methods We used Agilent Human Genome CGH Microarray Kit 44B 44K alterations in 25 male tissues studied at NCC Bari 16 deposited Gene...
Abstract Background COVID-19 has been characterised by its global and rapid spread, with high infection, hospitalisation, mortality rates worldwide. However, the course of pandemic showed differences in chronology intensity different geographical areas countries, probably due to a multitude factors. Among these, socio-economic deprivation supposed play substantial role, although available evidence is not fully agreement. Our study aimed assess incidence fatality across levels during first...
End-stage renal disease (ESRD) is associated with a broad spectrum of morphological and functional thyroid disorders. Recent studies have shown that low free triiodothyronine (fT3) levels are related to inflammatory status endothelial activation in ESRD patients on haemodialysis (HD). Limited data exist about possible relationship between dialysis regimen, namely long nocturnal (LNHD), function parameters. The aim this study was evaluate the regimen function, consequently main patient...
Recommendations in many countries state that preterm infants (PTIs) should receive the same routine immunization schedule and timing as for full-term births, according to their chronological age. Data regarding hexavalent vaccine safety PTIs are still limited. We conducted a post-marketing surveillance study of DTaP2-IPV-HB-Hib administered Apulia region, Italy. identified by selecting hospital discharge records born between January June 2017 using DRG ICD-9-CM codes birth, we matched these...
In Italy, vaccination against seasonal influenza has been recommended for the elderly since 1980, but coverage is still far below WHO minimum target level of 75%. Effective interventions to improve should take into account socioeconomic determinants inequalities in vaccine uptake. This study aimed assess differences coverage, by status, among people ≥ 65 years age residing Foggia municipality, Italy.A Socio-Economic-Health Deprivation Index (SEHDI) was constructed using a multivariate...
Background: The identification of relationship between genes and emotional distress mediated by personality traits among high level athletes may help to implement specific clinical psychology programs. Findings suggest that 5-HTTLPR genetic polymorphisms be associated with Harm Avoidance (HA). present research is aimed at evaluating the HA, serotonin transporter’s (5-HTTLPR) cognitive anxiety (CA) in during championship. Methods: 133 completed Temperament Character Inventory (TCI) test....
DNA copy number alterations have been discovered to be key genetic events in development and progression of cancer. No clear data familial sporadic breast cancer are available. We focused on looking for an independent platform as a tool identify the chromosomal profile versus patients. A total 124 patients were studied utilizing aCGH. The dataset was analyzed using Gaussian Mixture Models determine thresholds order assess gene changes minimize impact noise further analyses. identification...
During COVID-19 vaccination campaign, possible ChAdOx1-S-associated risks of thrombosis with thrombocytopenia syndrome led to implement ChAdOx1-S/BNT162b2 heterologous vaccination, despite the limited information on its reactogenicity and safety. We conducted a prospective observational post-marketing surveillance study assess safety this schedule. A casually selected sample recipients (n: 85; age: 18–60 years) at hub Foggia Hospital, Italy, was matched an equal homologous BNT162b2. Safety...