A5028574633- Cannabis and Cannabinoid Research
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Blood properties and coagulation
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Stress Responses and Cortisol
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Eating Disorders and Behaviors
- Diet, Metabolism, and Disease
- Biochemical Analysis and Sensing Techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Circadian rhythm and melatonin
- Erythrocyte Function and Pathophysiology
- Neurotransmitter Receptor Influence on Behavior
- Pharmacology and Obesity Treatment
- Pancreatic function and diabetes
- Alzheimer's disease research and treatments
- Biochemical effects in animals
- Sleep and Wakefulness Research
- Fatty Acid Research and Health
- Neuropeptides and Animal Physiology
- Peroxisome Proliferator-Activated Receptors
Sapienza University of Rome
2015-2024
University of Palermo
1984-2016
Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata
2014
University of Foggia
2014
Università di Camerino
2014
University of Zurich
2013
Azienda di Rilievo Nazionale ed Alta Specializzazione
2004
University of Naples Federico II
2000
Oleoylethanolamide (OEA) is a biologically active lipid amide that released by small-intestinal enterocytes during the absorption of dietary fat and inhibits feeding engaging nuclear receptor, peroxisome proliferator-activated receptor-alpha (PPAR-alpha). Previous studies have shown anorexic effects systemically administered OEA require activation sensory afferents vagus nerve. The central circuits involved in mediating OEA-induced hypophagia remain unknown. In present study, we report...
Significance Several endogenous molecules contribute to the building of a complex network neural and hormonal signals that align food intake energy expenditure. Cerebral histamine works as satiety factor by activating H 1 receptor (H R) in specific hypothalamic nuclei. Indeed, atypical antipsychotics presumably cause obesity targeting brain R. The lipid messenger oleoylethanolamide (OEA) mediates fat-induced engaging sensory fibers vagus nerve project centrally. We find depletion blunts...
Background:Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and have not yet been fully inves tigated murine models.
We developed recently a binge-eating model in which female rats with history of intermittent food restriction show binge-like palatable consumption after 15 min exposure to the sight food. This “frustration stress” manipulation also activates hypothalamic–pituitary–adrenal stress axis. Here, we determined role neurohormone corticotropin-releasing factor (CRF) stress-induced binge eating our model. assessed CRF receptors bed nucleus stria terminalis (BNST), brain region implicated responses...
Several factors play a role in obesity (i.e., behavior, environment, and genetics) epigenetic regulation of gene expression has emerged as potential contributor the susceptibility development obesity. To investigate individual sensitivity to weight gain/resistance, we here studied transcription several hypothalamic neuropeptides involved control energy balance rats developing (diet-induced obesity, DIO) or not (diet resistant, DR), when fed with high fat diet. Rats have been followed up 21...
A disruption to circadian rhythmicity and the sleep/wake cycle constitutes a major feature of Alzheimer's disease (AD). The maintenance is regulated by endogenous clock genes number external Zeitgebers, including light. This study investigated light induced changes in expression triple transgenic model AD (3×Tg-AD) their wild type littermates (Non-Tg). Changes gene were evaluated four brain areas¾suprachiasmatic nucleus (SCN), hippocampus, frontal cortex brainstem¾of 6- 18-month-old Non-Tg...
The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD). However, the association between CB1 alterations and development of AD n
Abstract Because binge eating and emotional vary through the menstrual cycle in human females, we investigated cyclic changes binge‐like female rats their control by estrogens. Binge‐like was elicited three cycles of 4 days food restriction free feeding followed a single frustrative nonreward‐stress episode (15 min visual olfactory exposure to familiar palatable food) immediately before presentation food. Intact showed during diestrous proestrous phases ovarian cycle, but not estrous...
Alzheimer's disease (AD) is a neurodegenerative disorder responsible for the majority of dementia cases in elderly people. It widely accepted that main hallmarks AD are not only senile plaques and neurofibrillary tangles but also reactive astrogliosis, which often precedes detrimental deposits neuronal atrophy. Such phenomenon facilitates regeneration neural networks; however, under some circumstances, like AD, astrogliosis detrimental, depriving neurons homeostatic support, thus...
Binge eating disorder (BED) is the most frequent disorder, for which current pharmacotherapies show poor response rates and safety concerns, thus highlighting need novel treatment options. The lipid-derived messenger oleoylethanolamide (OEA) acts as a satiety signal inhibiting food intake through involvement of central noradrenergic oxytocinergic neurons. We investigated anti-binge effects OEA in rat model binge-like eating, which, after cycles intermittent restrictions/refeeding palatable...
Abstract Autism Spectrum Disorders (ASD) are principally diagnosed by three core behavioural symptoms, such as stereotyped repertoire, communication impairments and social dysfunctions. This complex pathology has been linked to abnormalities of corticostriatal limbic circuits. Despite experimental efforts in elucidating the molecular mechanisms behind these abnormalities, a clear etiopathogenic hypothesis is still lacking. To this aim, preclinical studies can be really helpful longitudinally...
By enhancing brain anandamide tone, inhibitors of fatty acid amide hydrolase (FAAH) induce anxiolytic-like effects in rodents and enhance serotonergic transmission. Mice lacking the faah gene (FAAH−/−) show higher levels. However, their emotional phenotype is still debated tone remained unexplored. In this study, we tested FAAH−/− mice social interaction open field tests performed under different lighting conditions (dim bright) since variations experimental context were proposed to explain...