A5034333937- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Ethics and Legal Issues in Pediatric Healthcare
- Pharmaceutical studies and practices
- Neuroscience of respiration and sleep
- Ethics in Clinical Research
- Neonatal Health and Biochemistry
- Cannabis and Cannabinoid Research
- Hemoglobinopathies and Related Disorders
- Stress Responses and Cortisol
- Pharmacological Effects and Toxicity Studies
- Neurotransmitter Receptor Influence on Behavior
- Health Systems, Economic Evaluations, Quality of Life
- Sleep and Wakefulness Research
- Pharmacology and Obesity Treatment
- Dietary Effects on Health
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Blood disorders and treatments
- Neuropeptides and Animal Physiology
- Blood groups and transfusion
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Iron Metabolism and Disorders
- Alzheimer's disease research and treatments
Consorzio per Valutazioni Biologiche e Farmacologiche
2019-2021
Sapienza University of Rome
2013-2017
Università di Camerino
2014
University of Foggia
2014
Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata
2014
Background:Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and have not yet been fully inves tigated murine models.
Oleoylethanolamide (OEA) is a gut-derived endogenous lipid that stimulates vagal fibers to induce satiety. Our previous work has shown peripherally administered OEA activates c-fos transcription in the nucleus of solitary tract (NST) and paraventricular (PVN), where it enhances oxytocin (OXY) expression. The anorexigenic action prevented by intracerebroventricular administration selective OXY receptor antagonist, suggesting necessary role OXYergic mediation OEA's effect. NST source direct...
Limbic forebrain endocannabinoid (eCB) signaling is critically involved in stress integration by modulating neurotransmitters release. The purpose of this study was to examine, brain microdialysis, the effects fatty acid amide hydrolase (FAAH) inhibition on noradrenergic and γ‐aminobutyric (GABA)‐ergic neurotransmission prefrontal cortex (PFC) basolateral amygdala (BLA) rats subjected a 20‐min swim stress. Microdialysis started stress‐ drug‐naïve that were treated with FAAH inhibitor URB597...
We describe our experience from a multi-national application of European Union-funded research-driven paediatric trial (DEEP-2, EudraCT 2012-000353-31; NCT01825512). This paper aims to evaluate the impact local and national rules on authorisation process in non-European countries. National/local provisions procedures, number Ethics Committees Competent Authorities be addressed, documentation required, special for population, timelines completing queries received were collected; compliance...
Background: While the efficacy and safety of deferiprone (DFP) in adult patients with transfusion‐dependent hemoglobinopathies (TDH) has been extensively studied, data children are sparse. Aims: We report results DEferiprone Evaluation Pediatrics‐2 (DEEP‐2), (EudraCT Number 2012‐000353‐31), a Phase III multicentre, randomized, open label study funded by EU FP7 Research Program, to compare DFP liquid formulation versus deferasirox dispersible tablets (DFX). Methods: DEEP‐2 was...
Abstract Background . We describe our experience from a multi-national application of European Union-funded research-driven paediatric trial (DEEP-2, EudraCT 2012-000353-31; NCT01825512).This paper aims to evaluate the impact local and national rules on authorisation process in non-European countries. National/local provisions procedures, number Ethics Committees Competent Authorities be addressed, documentation required, special for population, timelines completing queries received were...