A5042498098- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Dietary Effects on Health
- Regulation of Appetite and Obesity
- Adenosine and Purinergic Signaling
- Neuroendocrine regulation and behavior
- Biochemical effects in animals
- Autism Spectrum Disorder Research
- GABA and Rice Research
- Alcohol Consumption and Health Effects
- Monoclonal and Polyclonal Antibodies Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics and Neurodevelopmental Disorders
- Biochemical Acid Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Neurogenesis and neuroplasticity mechanisms
- Climate change impacts on agriculture
- Parkinson's Disease Mechanisms and Treatments
- Inhalation and Respiratory Drug Delivery
- Memory and Neural Mechanisms
ImmunoGen (United States)
2024
Vanderbilt University
2018-2021
Institute of Behavioral Sciences
2021
Vanderbilt University Medical Center
2017-2020
University School of Nashville
2019
Sapienza University of Rome
2011-2017
University of Foggia
2014
Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata
2014
Università di Camerino
2014
National Institute of Pharmaceutical Education and Research
2009
Recent studies have demonstrated anxiolytic potential of pharmacological endocannabinoid (eCB) augmentation approaches in a variety preclinical models. Pharmacological inhibition endocannabinoid-degrading enzymes, such as fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), elicit promising effects rodent models with limited adverse behavioral effects, however, the efficacy dual FAAH/MAGL has not been investigated. In present study, we compared FAAH (PF-3845), MAGL (JZL184)...
Background:Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and have not yet been fully inves tigated murine models.
The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD). However, the association between CB1 alterations and development of AD n
Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung disease characterized by scar formation and respiratory insufficiency, which progressively leads to death. hypertension (PH) common complication of IPF that negatively impacts clinical outcomes, has been classified as Group III PH. Despite scientific advances, the dismal prognosis associated PH remains unchanged, necessitating search for novel therapeutic strategies. Accumulating evidence suggests stimulation angiotensin II type 2 (AT2)...
Chromosomal deletions at Xp22.3 appear to influence vulnerability the neurodevelopmental disorders attention deficit hyperactivity disorder (ADHD) and autism. 39,X(Y*)O mice, which lack murine orthologue of ADHD candidate gene STS (encoding steroid sulfatase), exhibit behavioural phenotypes relevant such (e.g. hyperactivity), elevated hippocampal serotonin (5-HT) levels, reduced serum levels dehydroepiandrosterone (DHEA). Here we initially show that mice are also deficient for...
The initial pharmaceutical interest for the endocannabinoid system as a target antiobesity therapies has been restricted by severe adverse effects of CB1 antagonist rimonabant. This study points at oleoylethanolamide (OEA), monounsaturated analogue, and functional anandamide, potential safer alternative to antagonism. Mice treated with equal doses (5 or 10 mg/kg, i.p.) OEA rimonabant were analyzed progressive expression spontaneous behaviors (eating, grooming, rearing, locomotion, resting)...
Chronic stress increases the probability of receiving an anxiety, depression, or chronic illness diagnosis. Pharmacological interventions that reduce behavioral and physiological effects in animal models may represent novel approaches for treatment stress-related psychiatric disorders. Here, we examined cyclooxygenase-2 (COX-2) inhibition on anxiety-like behaviors amygdala glutamatergic signaling after non-invasive oral corticosterone (CORT) administration mice. Treatment with highly...
Autism Spectrum Disorders (ASD) are neurodevelopmental disorders with multifactorial origin characterized by social communication and behavioural perseveration deficits. Several studies showed an association between the reelin gene mutation increased risk of ASD a reduced expression in some brain regions subjects, suggesting role for deficiency etiology. Reelin is large extracellular matrix glycoprotein playing important roles during development central nervous system. To deeply investigate...
Limbic forebrain endocannabinoid (eCB) signaling is critically involved in stress integration by modulating neurotransmitters release. The purpose of this study was to examine, brain microdialysis, the effects fatty acid amide hydrolase (FAAH) inhibition on noradrenergic and γ‐aminobutyric (GABA)‐ergic neurotransmission prefrontal cortex (PFC) basolateral amygdala (BLA) rats subjected a 20‐min swim stress. Microdialysis started stress‐ drug‐naïve that were treated with FAAH inhibitor URB597...
Alcohol use disorder (AUD) is associated with substantial morbidity, mortality, and societal cost, pharmacological treatment options for AUD are limited. The endogenous cannabinoid (eCB) signaling system critically involved in reward processing alcohol intake positively correlated release of the eCB ligand 2-Arachidonoylglycerol (2-AG) within neurocircuitry. Here we show that genetic inhibition diacylglycerol lipase (DAGL), rate limiting enzyme synthesis 2-AG, reduces consumption a variety...