A5005497098- Obsessive-Compulsive Spectrum Disorders
- Stress Responses and Cortisol
- Eating Disorders and Behaviors
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Brain Metastases and Treatment
- Cancer Cells and Metastasis
- Tryptophan and brain disorders
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Obesity, Physical Activity, Diet
- Glioma Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Medical Imaging Techniques and Applications
- Nerve injury and regeneration
- Autism Spectrum Disorder Research
- Cell Image Analysis Techniques
- Radiopharmaceutical Chemistry and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neuroendocrine regulation and behavior
- PI3K/AKT/mTOR signaling in cancer
- Neuroscience of respiration and sleep
- Neuropeptides and Animal Physiology
- Adrenal Hormones and Disorders
Vanderbilt University Medical Center
2018-2025
Michigan Medicine
2023
Institute of Behavioral Sciences
2021
University of Michigan
1992-2019
Michigan United
2019
Ann Arbor Center for Independent Living
2019
Central Michigan University
2014
Cornell University
2000-2009
New York Proton Center
2007
National Institute of Mental Health
1993-1999
Prefrontal mechanisms are implicated in obsessive-compulsive disorder. The authors investigated whether prefrontal repetitive transcranial magnetic stimulation influenced disorder symptoms.Twelve patients with were given (80% motor threshold, 20 Hz/2 seconds per minute for minutes) to a right lateral prefrontal, left and midoccipital (control) site on separate days, randomized. patients' symptoms mood rated 8 hours afterward.Compulsive urges decreased significantly after stimulation, but...
Levels of CSF fluid interleukin-2, but not interleukin-1 alpha, were found to be higher in 10 neuroleptic-free schizophrenic patients than healthy subjects matched for sex and age. Because interleukin-2 increases dopaminergic neurotransmission participates autoimmunity cell growth, the authors postulate that elevated levels central might contribute increased neurotransmission, autoimmune phenomena, abnormal brain morphology described some with schizophrenia.
Deficits in social interaction (SI) are a core symptom of autism spectrum disorders (ASDs); however, treatments for deficits notably lacking. Elucidating brain circuits and neuromodulatory signaling systems that regulate sociability could facilitate deeper understanding ASD pathophysiology reveal novel ASDs. Here we found vivo optogenetic activation the basolateral amygdala-nucleus accumbens (BLA-NAc) glutamatergic circuit reduced SI increased avoidance mice. Furthermore,...
The mechanisms by which stress and anti-depressants exert opposite effects on the course of clinical depression are not known. However, potential candidates might include neurotrophic factors that regulate development, plasticity, survival neurons. To explore this hypothesis, we examined antidepressants neurotrophin expression in locus coeruleus (LC), modulates many behavioral physiological responses to has been implicated mood disorders. Using situ hybridization, demonstrate 3 (NT-3) is...
In breast cancer, tumor hypoxia has been linked to poor prognosis and increased metastasis. Hypoxia activates transcriptional programs in cancer cells that lead motility invasion, as well various metabolic changes. One of these changes, an increase glycogen metabolism, further associated with protection from reactive oxygen species damage may premature senescence. Here we report significantly stores response hypoxia. We found knockdown the brain isoform enzyme catalyzes breakdown,...
ABSTRACT Defective endocytosis and vesicular trafficking of signaling receptors has recently emerged as a multifaceted hallmark malignant cells. Clathrin-coated pits (CCPs) display highly heterogeneous dynamics on the plasma membrane where they can take from 20 s to over 1 min form cytosolic coated vesicles. Despite large number cargo molecules that traffic through CCPs, it is not well understood whether activated in cancer, such epidermal growth factor receptor (EGFR), are regulated...
Abstract Inflammatory breast cancer (IBC) is the most lethal form of cancer. All IBC patients have lymph node involvement and one-third already distant metastasis at diagnosis. This propensity for a hallmark distinguishing it from less non-inflammatory cancers (nIBC). Genetic profiling studies been conducted to differentiate nIBC, but no cancer-cell-specific gene signature has identified. We hypothesized that tumor-extrinsic factor, notably tumor-associated macrophages, promotes contributes...
Brain metastases are the most lethal complication of advanced cancer; therefore, it is critical to identify when a tumor has potential metastasize brain. There currently no interventions that shed light on primary tumors We constructed and tested platform quantitatively profile dynamic phenotypes cancer cells from aggressive triple negative breast cell lines patient derived xenografts (PDXs), generated brain diverse organs origin. Combining an live imaging algorithm artificial intelligence,...
Maladaptive fear generalization is one of the hallmarks trauma-related disorders. The endocannabinoid 2-arachidonoylglycerol (2-AG) crucial for modulating anxiety, fear, and stress adaptation but its role in balancing discrimination versus not known. To address this, we used a combination plasma measurement neuroimaging from childhood maltreatment-exposed non-exposed mixed population combined with human rodent conditioning models. Here show that 2-AG levels are inversely associated at...
This study was designed to explore potential overlap of the symptoms obsessive-compulsive disorder and eating disorders.The authors administered a structured, self-rating scale, Eating Disorder Inventory, 59 outpatients at an clinic 60 sex-matched normal volunteers. The Inventory has been previously validated as reliable measure specific cognitive behavioral dimensions psychopathology typical patients with disorders. scores healthy comparison subjects were compared those 32 female inpatients...
The authors' purpose in this study was to further delineate the character of cerebral metabolism bulimia nervosa and determine if functional links could be made between regional symptoms depression, obsessive-compulsive disorder, nervosa.Regional glucose measured by using positron emission tomography 11 inpatients with 18 normal comparison subjects matched sex (all were women), age, educational level. bulimic patients also tested for major depression disorder.The showed a correlation lower...
Cyclooxygenase-2 (COX-2) catalyzes the formation of prostaglandins, which are involved in immune regulation, vascular function, and synaptic signaling. COX-2 also inactivates endogenous cannabinoid (eCB) 2-arachidonoylglycerol (2-AG) via oxygenation its arachidonic acid backbone to form a variety prostaglandin glyceryl esters (PG-Gs). Although this reaction is readily observed vitro intact cells, detection COX-2-derived 2-AG products has not been previously reported neuronal tissue. Here we...
Six patients with anorexia nervosa, the same after weight normalization, and six healthy control subjects had similar fasting postprandial plasma cholecystokinin concentrations. These data do not support hypothesis that low levels of hunger food intake in anorexic reflect hypersecretion this endogenous hormone, which is thought to inhibit hunger, promote satiety, reduce feeding.
Alcohol use disorder (AUD) is associated with substantial morbidity, mortality, and societal cost, pharmacological treatment options for AUD are limited. The endogenous cannabinoid (eCB) signaling system critically involved in reward processing alcohol intake positively correlated release of the eCB ligand 2-Arachidonoylglycerol (2-AG) within neurocircuitry. Here we show that genetic inhibition diacylglycerol lipase (DAGL), rate limiting enzyme synthesis 2-AG, reduces consumption a variety...
Brain metastases are the most lethal progression events, in part because biological processes underpinning brain poorly understood. There is a paucity of realistic models metastasis, as current vivo murine slow to manifest metastasis. Metabolic and secretory modulators utilizing two consisting vitro microfluidic devices delineated: 1) blood–brain niche (BBN) chip that recapitulates blood–brain‐ barrier niche; 2) migration assesses cell migration. Secretory cues provided by attract metastatic...
Abstract Maladaptive fear generalization is one of the hallmarks trauma-related disorders. The endocannabinoid 2-arachidonoylglycerol (2-AG) crucial for modulating anxiety, fear, and stress adaptation but its role in balancing discrimination versus not known. To address this, we used a combination plasma measurement neuroimaging from childhood maltreatment exposed non-exposed mixed population combined with human rodent conditioning models. Here show that 2-AG levels are inversely associated...
Bulimia nervosa is a psychiatric syndrome associated with intense hunger, deficient satiety mechanisms, an obsessional preoccupation the adverse consequences of eating, ritualistic binge and subsequent purging to forestall effects binge. The morbidity this illness reflects both psychological suffering life organized around pathological eating behaviors, as well medical complications such fluid electrolyte imbalances that occur largely result laxative abuse. We report here study...
Because the central administration of somatostatin to experimental animals produces behaviors with some similarities compulsions patients obsessive-compulsive disorder and because serotonin reuptake inhibitors have been reported reduce brain content somatostatin, authors examined activity in disorder.CSF for measurement was obtained from 15 drug-free outpatients 27 normal volunteers.The mean CSF level significantly higher than subjects.Although functional significance this finding is...