A5085708287- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Drug Solubulity and Delivery Systems
- Pesticide Residue Analysis and Safety
- Drug Transport and Resistance Mechanisms
- HIV/AIDS drug development and treatment
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical studies and practices
- Computational Drug Discovery Methods
- Drug-Induced Hepatotoxicity and Protection
- Mass Spectrometry Techniques and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Protein purification and stability
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Sensors
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmacological Effects of Natural Compounds
- Cancer therapeutics and mechanisms
- Tuberculosis Research and Epidemiology
- Malaria Research and Control
- Pharmaceutical Quality and Counterfeiting
- Biosimilars and Bioanalytical Methods
- Biochemical and Molecular Research
National Institute of Pharmaceutical Education and Research
2003-2025
National Institute of Pharmaceutical Education and Research
2023
National Institute of Pharmaceutical Education and Research
2013-2022
Washington State University Spokane
2021
Indo Soviet Friendship College of Pharmacy
2020-2021
Brown University
2021
Maharishi Markandeshwar University, Mullana
2020
Simulations Plus (United States)
2019
University of Washington
2019
Children's Mercy Hospital
2019
The COVID-19 disease is caused by a new strain of the coronavirus family (SARS-CoV-2), and it has affected at present millions people all over world. indispensable role main protease (Mpro) in viral replication gene expression makes this enzyme an attractive drug target. Therefore, inhibition SARS-CoV-2 Mpro as proposition to halt virus ingression being pursued scientists globally. Here we carried out study with two objectives: first perform comparative protein sequence 3D structural...
Cytosolic sulfotransferases (SULTs), including SULT1A, SULT1B, SULT1E, and SULT2A isoforms, play noteworthy roles in xenobiotic endobiotic metabolism. We quantified the protein abundances of SULT1A1, SULT1A3, SULT1B1, SULT2A1 human liver cytosol samples (n = 194) by liquid chromatography-tandem mass spectrometry proteomics. The data were analyzed for their associations age, sex, genotype, ethnicity donors. showed significant age-dependent abundance, whereas SULT1A3 was invariable across 0-70...
Abstract Population factors such as age, gender, ethnicity, genotype and disease state can cause inter-individual variability in pharmacokinetic (PK) profile of drugs. Primarily, this arises from differences abundance drug metabolizing enzymes transporters (DMET) among individuals and/or groups. Hence, availability compiled data on DMET proteins different populations be useful for developing physiologically based (PBPK) models. The latter are routinely employed prediction PK profiles...
The poor bioavailability of rifampicin from fixed-dose combinations containing isoniazid has been attributed to isoniazid-catalysed degradation under acid conditions in the stomach. mechanism by which enhances is not known. aim this study was determine role decomposition. Degradation studies were performed 0.1 M HCl at 37°, absence and presence isoniazid. Both analysed. increased approximately threefold Isoniazid itself degraded a lesser extent amounting one-fifth fall rifampicin. HPLC...
A comprehensive mass fragmentation pathway of atorvastatin, which has not been reported so far, was established by subjecting the drug to multi-stage spectrometric (MSn) studies. It used along with liquid chromatography/mass (LC/MS) and chromatography/time-of-flight (LC/TOFMS) analyses identify degradation products formed under stress conditions hydrolysis, oxidation photolysis. Other than lactone, is a hydrolysis product, six unknown hydrolytic could be identified, viz., dehydrated drug,...