A5009782782- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Pesticide Residue Analysis and Safety
- Antibiotics Pharmacokinetics and Efficacy
- Protein purification and stability
- Mass Spectrometry Techniques and Applications
- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Inflammatory mediators and NSAID effects
- Peptidase Inhibition and Analysis
- Advanced Chemical Sensor Technologies
- Hormonal and reproductive studies
- Pharmaceutical Quality and Counterfeiting
- Protein Degradation and Inhibitors
- Analytical chemistry methods development
- Pharmaceutical Economics and Policy
- Biopolymer Synthesis and Applications
- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Sensors
- Pharmaceutical Practices and Patient Outcomes
- Chemical Synthesis and Analysis
- Estrogen and related hormone effects
- Drug Solubulity and Delivery Systems
- Parkinson's Disease Mechanisms and Treatments
- Medication Adherence and Compliance
National Institute of Pharmaceutical Education and Research
2011-2025
Government of India
2021-2024
Syngene International (India)
2013-2020
Biocon (India)
2013-2020
Bristol-Myers Squibb (India)
2013-2020
National Institute of Pharmaceutical Education and Research
2008-2013
Swedish University of Agricultural Sciences
2011
University of the Sciences
2006
Veterans Health Administration
2003
University of Cincinnati
2003
Quantifying reactive aldehyde biomarkers, such as malondialdehyde, acrolein, and crotonaldehyde, is the most preferred approach to determine oxidative stress. However, reported analytical methods lack specificity for accurately quantifying these aldehydes certain methodologies may produce false positive results due harsh experimental conditions. Thus, in this research work, a novel HILIC-MS/MS method with endogenous histidine derivatization developed, which proves have higher reproducibility...
Accumulation of misfolded α-synuclein (α-Syn) leads to the formation Lewy bodies and is a major hallmark Parkinson's disease (PD). The accumulation α-Syn involves several post-translational modifications. Recently, though, glycation (advanced end products) activation receptor for advanced products (RAGE) have been linked neuroinflammation, which oxidative stress α-Syn. present study aims detect effect glycated (gly-α-Syn)-induced synucleinopathy loss dopaminergic (DAergic) neurons in...
Malondialdehyde (MDA), a major reactive byproduct of lipid peroxidation, has been implicated in numerous pathological conditions as result altering the structure and function crucial proteins. One such protein is α-synuclein (α-Syn), which plays vital role pathogenesis Parkinson's disease (PD). This study investigates hypothesis that MDA causes structural alterations α-Syn, promoting its aggregation exacerbating toxicological effects. In vivo experiments were conducted where MDA-modified...
To compute ratios of severe pregnancy complications (the number hospitalizations for per 100 deliveries) and to examine factors associated with their prevalence.Using population-based California hospital discharge data estimate hospitalization during 1987-1992, we defined cases by preselected complication codes from the International Classification Diseases, Ninth Revision, Clinical Modification, excluding induced abortions delivery-associated complications. All deliveries liveborn or...
A comprehensive mass fragmentation pathway of atorvastatin, which has not been reported so far, was established by subjecting the drug to multi-stage spectrometric (MSn) studies. It used along with liquid chromatography/mass (LC/MS) and chromatography/time-of-flight (LC/TOFMS) analyses identify degradation products formed under stress conditions hydrolysis, oxidation photolysis. Other than lactone, is a hydrolysis product, six unknown hydrolytic could be identified, viz., dehydrated drug,...
Dalbavancin is the second-generation approved semisynthetic lipoglycopeptide by United States Food and Drug Administration (USFDA) for treatment of acute bacterial skin skin-structure infections. Unlike other lipoglycopeptides, stability behavior was least explored, which a prerequisite. The current study endeavors to elucidate oxidative hydrolytic exposing drug oxidative, acidic, basic stress conditions. A simple liquid chromatography (LC) method developed, where significant resolution...
Abstract The present study demonstrates the applicability of a strategy involving use liquid chromatography (LC) and chromatography‐mass spectrometry (LC‐MS) techniques for identification characterization minute quantities degradation products, without their isolation from reaction matrix in pure form. Valsartan was used as model drug. It subjected to forced studies under International Conference on Harmonisation (ICH) prescribed conditions hydrolysis (acid, base neutral), photolysis,...
Molnupiravir is a recently approved drug against the ongoing worldwide pandemic of COVID-19. The current study endeavors to identify and characterize degradation products molnupiravir using LC-MS/MS for rapid development. HPLC separation was achieved Waters Xselect HSS T3 (75 × 4.6 mm, 2.5 µm) column with ammonium formate ACN as mobile phase in gradient elution mode. injection volume 5 µL 0.7 mL/min flow rate. detection wavelength 272 nm all performed at constant temperature 25 °C. MS/MS its...